The influence of reproductive hormones on systemic lupus erythematosus

R. Sachdeva, R. Pal
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Abstract

Humans are afflicted by a wide spectrum of autoimmune disorders, ranging from those affecting just one or a few organs to those associated with more systemic effects. In most instances, the etiology of such disorders remains unknown; a consequence of this lack of knowledge is a lack of specific treatment options. Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disorder; pathology is believed to be antibody-mediated, and multiple organs are targeted. Periods of disease “flares” are often followed by long periods of remission. The fact that SLE is more commonly observed in females, and also that it more particularly manifests in females in the reproductive age group, has quite naturally drawn attention to the potential roles that hormones play in disease onset and progression. This review attempts to shed light on the influences that key hormones might have on disease indicators and pathology. Databases (Google Scholar, PubMed) were searched for the following keywords (sometimes in certain combinations), in conjunction with the term “lupus” or “SLE”: autoantibodies, recurrent abortion, polycystic ovarian syndrome (PCOS), preeclampsia, pre-term delivery, estrogens, progesterone, androgens, prolactin, leptin, human chorionic gonadotropin (hCG). Cited publications included both research articles and reviews.
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生殖激素对系统性红斑狼疮的影响
人类受到广泛的自身免疫性疾病的折磨,从只影响一个或几个器官的疾病到与更系统性影响相关的疾病。在大多数情况下,这种疾病的病因仍然未知;这种缺乏知识的后果是缺乏具体的治疗选择。系统性红斑狼疮(SLE)是典型的系统性自身免疫性疾病;病理学被认为是抗体介导的,并且多个器官是靶向的。疾病“发作”后往往会有很长一段时间的缓解期。SLE在女性中更常见,而且在育龄女性中更为明显,这一事实很自然地引起了人们对激素在疾病发作和进展中发挥的潜在作用的关注。这篇综述试图阐明关键激素可能对疾病指标和病理学产生的影响。在数据库(Google Scholar,PubMed)中搜索以下关键词(有时是某些组合),并结合术语“狼疮”或“SLE”:自身抗体、复发性流产、多囊卵巢综合征(PCOS)、先兆子痫、早产、雌激素、孕酮、雄激素、泌乳素、瘦素、人绒毛膜促性腺激素(hCG)。引用的出版物包括研究文章和评论。
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