{"title":"Advances in breast cancer organoid for individualized treatment","authors":"Xuelu Li , Dandan Zhu","doi":"10.1016/j.ooc.2023.100028","DOIUrl":null,"url":null,"abstract":"<div><p>Breast organoids and breast cancer organoids have been a crucial tool for mammary gland and breast cancer research. In the last several years, breast cancer organoids have shown tremendous potentials for largely mimicking the structural and functional features of the original breast cancer tissue. In this review, the cell source and strategy for generating breast cancer organoids will be introduced. Then, the current progress of breast cancer organoids will be summarized, including disease model, living biobank, drug screening and personalized therapy. Ultimately, we will discuss the future opportunities and challenges of current breast cancer organoids from basic to clinical.</p></div>","PeriodicalId":74371,"journal":{"name":"Organs-on-a-chip","volume":"5 ","pages":"Article 100028"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organs-on-a-chip","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666102023000034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Breast organoids and breast cancer organoids have been a crucial tool for mammary gland and breast cancer research. In the last several years, breast cancer organoids have shown tremendous potentials for largely mimicking the structural and functional features of the original breast cancer tissue. In this review, the cell source and strategy for generating breast cancer organoids will be introduced. Then, the current progress of breast cancer organoids will be summarized, including disease model, living biobank, drug screening and personalized therapy. Ultimately, we will discuss the future opportunities and challenges of current breast cancer organoids from basic to clinical.
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