The Effect of Shrimp Shell (Litopenaeus vannamei) Extract on Testicular Parameters of Streptozotocin-induced Diabetic Rats

Q4 Veterinary World''s Veterinary Journal Pub Date : 2023-03-25 DOI:10.54203/scil.2023.wvj15

Aniek Prasetyaningsih, Y. K. Adi, Abner Amadeuz Wicaksono, V. C. Prakasita

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Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder that has become a major health problem worldwide. Reproductive dysfunction is one of the main complications of DM, particularly in men. However, as is known, shrimp shell extract contains nutrients, such as astaxanthin, that affect reproductive traits. The present study aimed to evaluate the effect of shrimp shell extract on the volume, weight, and histological features of the testes of a DM rat model. Fifteen adult male rats were randomly divided into three groups. Group A (n = 5) was a healthy control group, group B (n = 5) was a DM control group, and group C (n = 5) was a DM group treated with shrimp shell extract. Rats in groups B and C were treated with streptozotocin to induce DM. Rats in group C were given shrimp shell extract at 25 mg/kg body weight for 30 consecutive days after DM induction. Testicles were collected and submitted to dimension, weight, and histological examinations. The testicle volume and weight of rats in group C were significantly higher and heavier, respectively, than rats in group B and did not differ from rats in group A. The seminiferous tubule diameter of rats in group C was significantly larger than rats in group B and did not differ from rats in group A. Rats in group B had a lower testicle volume and lighter testicle weight as well as a shorter seminiferous tubule diameter than rats in groups A and C. In conclusion, shrimp shell extract could improve male fertility parameters in a DM rat model. However, the mechanism of action needs to be studied further.

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凡纳滨对虾壳提取物对链脲佐菌素诱导的糖尿病大鼠睾丸参数的影响

糖尿病（DM）是一种慢性代谢紊乱，已成为世界范围内的一个主要健康问题。生殖功能障碍是糖尿病的主要并发症之一，尤其是男性。然而，众所周知，虾壳提取物含有虾青素等营养物质，会影响生殖特性。本研究旨在评估虾壳提取物对糖尿病大鼠模型睾丸体积、重量和组织学特征的影响。将15只成年雄性大鼠随机分为三组。A组为健康对照组，B组为DM对照组，C组为虾皮提取物治疗DM组。B组和C组用链脲佐菌素诱导糖尿病，C组在诱导糖尿病后连续30天给予虾壳提取物25mg/kg体重。收集睾丸并进行尺寸、重量和组织学检查。C组大鼠的睾丸体积和重量分别显著高于B组大鼠和较重大鼠，与A组大鼠无差异。与a组和C组相比，B组大鼠的睾丸体积较低，睾丸重量较轻，曲细精管直径较短。总之，虾壳提取物可以改善DM大鼠模型中的雄性生育参数。然而，作用机制还有待进一步研究。

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来源期刊

World''s Veterinary Journal Veterinary-Veterinary (all)

CiteScore

1.00

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0.00%

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期刊介绍： The World''s Veterinary Journal (ISSN 2322-4568) is an international, peer reviewed open access journal aims to publish the high quality material from veterinary scientists'' studies. All accepted articles are published Quarterly in full text on the Internet. WVJ publishes the results of original scientific researches, reviews, case reports and short communications, in all fields of veterinary science. In details, topics are: Behavior Environment and welfare Animal reproduction and production Parasitology Endocrinology Microbiology Immunology Pathology Pharmacology Epidemiology Molecular biology Immunogenetics Surgery Virology Physiology Vaccination Gynecology Exotic animals Animal diseases Radiology Ophthalmology Dermatology Chronic disease Anatomy Non-surgical pathology issues of small to large animals Cardiology and oncology.