Research progress in the effects of regulation of mitochondria by microRNAs and long non-coding RNAs on cerebral ischemia/reperfusion injury

国际麻醉学与复苏杂志 Pub Date : 2020-01-15 DOI:10.3760/CMA.J.ISSN.1673-4378.2020.01.024

Yanan Tang, Qian Zhang, Gaofeng Zhang, Huai-long Chen, Xiao-peng Sun, Fei Shi

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Abstract

Cerebral ischemia/reperfusion injury (CI/RI) is a common clinical pathophysiological phenomenon after thrombus recanalization in stroke patients. Its pathogenetic mechanism involves multiple steps, of which mitochondria play a key role as "energy stations". Cerebral ischemic stroke induces remarkable changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the brain, which indicates the association of miRNAs and lncRNAs of the complex pathological process after ischemic stroke. In addition, some related miRNAs and lncRNAs are found to participate in the development of CI/RI by regulating mitochondria. The current review is designed to summarize the effects of mitochondria on CI/RI, and the latest research findings about the involvement of miRNAs and lncRNAs to regulate CI/RI, so as to provide new targets and ideas for the prevention and treatment of CI/RI, as well as new thoughts and ideas for the prevention and treatment of CI/RI. Key words: Cerebral ischemia; Reperfusion injury; Mitochondria; MicroRNAs; Long non-coding RNAs

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小rna和长链非编码rna调控线粒体对脑缺血再灌注损伤影响的研究进展

脑缺血/再灌注损伤（CI/RI）是脑卒中患者血栓再通后常见的临床病理生理现象。其发病机制涉及多个步骤，其中线粒体作为“能量站”起着关键作用。缺血性脑卒中引起脑内微小RNA（miRNA）和长非编码RNA（lncRNA）表达的显著变化，表明miRNA和lncRNA在缺血性脑卒中后复杂病理过程中的相关性。此外，一些相关的miRNA和lncRNA被发现通过调节线粒体参与CI/RI的发展。本综述旨在总结线粒体对CI/RI的影响，以及miRNAs和lncRNAs参与调节CI/RI方面的最新研究发现，为预防和治疗CI/RI提供新的靶点和思路，并为防治CI/RI提出新的思路和思路。关键词：脑缺血；再灌注损伤；线粒体；微小RNA；长非编码RNA

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国际麻醉学与复苏杂志

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