Nano-encapsulation of curcumin in fish collagen grafted succinyl chitosan hydrogel accelerates wound healing process in experimental rats

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2022-12-01 DOI:10.1016/j.fhfh.2022.100061

Niladri Sekhar Chatterjee , Hema Girija Sukumaran , Pavan Kumar Dara , Balaraman Ganesan , Muhamed Ashraf , Rangasamy Anandan , Suseela Mathew , Ravishankar Chandragiri Nagarajarao

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引用次数: 12

Abstract

Succinyl chitosan-fish collagen composite hydrogel containing nano-encapsulated curcumin was developed for wound healing application. Curcumin was encapsulated in succinyl chitosan nano-particles using ionic gelation technique. The Z-average diameter of the nanoparticles as observed by dynamic light scattering experiment was ∼47 nm. Similar size ranges were observed in atomic force microscope (AFM) and transmission electron microscopy (TEM) images. A simple one pot gelation of the composite hydrogel containing nano-encapsulated curcumin was achieved by crosslinking succinyl chitosan and fish collagen with caffeic acid. The scanning electron microscopy (SEM) images of the crosslinked hydrogel showed porous sheet like/spongy morphology typical to crosslinked hydrogels. The developed hydrogel was evaluated for its wound healing efficacy in subcutaneous wound model on Wistar albino rats. The hydrogel significantly enhanced the collagen deposition and hydroxyproline content of 599.4 μg/gm and 74.9 μg/gm in wound tissue on the 14th day of post wounding.

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鱼胶原膜移植琥珀酰壳聚糖水凝胶中姜黄素的纳米包封促进实验大鼠伤口愈合

研制了琥珀酰壳聚糖-鱼胶原复合水凝胶，用于伤口愈合。采用离子凝胶技术将姜黄素包被琥珀酰壳聚糖纳米颗粒。动态光散射实验观察到纳米粒子的z -平均直径为~ 47 nm。在原子力显微镜(AFM)和透射电子显微镜(TEM)图像中观察到类似的尺寸范围。用琥珀酰壳聚糖和鱼胶原蛋白与咖啡酸交联制备了纳米姜黄素复合水凝胶。交联水凝胶的扫描电镜(SEM)图像显示了交联水凝胶典型的多孔片状/海绵状形态。对制备的水凝胶在Wistar白化大鼠皮下创面模型中的愈合效果进行了评价。在伤后第14天，水凝胶显著提高了伤口组织中胶原沉积和羟脯氨酸含量，分别为599.4 μg/gm和74.9 μg/gm。

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