Ulcer Index and Anti-Inflammatory Testing of Some Benzimidazole Derivatives

Abstract

In this work, we carry out the testing of some Benzimidazole derivatives as anti-inflammatory using Indomethacin 10mg/Kg, diclofenac sodium 7mg/ Kg, celecoxib 100mg/Kg and tested compounds of 200mg/Kg. The tested compounds showed anti-inflammatory activity in comparison with the standard reference drugs. In additionally, carrying out the testing of ulcer index for some testing compounds 600mg/Kg comparing with indomethacin 100mg/Kg, the testing revealed indomethacin causes ulcer in stomach of the testing animals, while the testing compounds no ulcerated the stomach of the testing animal.