Correlation of thyroid function and iodine nutritional status among pregnant women of Han nationality in Urumqi

Q4 Nursing 中华临床营养杂志 Pub Date : 2018-04-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2018.02.004

Xue-mian Lu, A. LiyaJilili

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Abstract

Objective To establish reference interval of thyroid hormones in pregnant women in Urumqi, standardize the diagnostic criteria of thyroid diseases in pregnancy, assess the iodine nutrition and thyroid function at different stages of pregnancy, and provide evidence to guide iodine supplementation. Methods A cross-sectional survey was performed in 3 731 pregnant women in Urumqi from May 2015 to June 2016. 1 206 of them were in the first trimester, 1 125 in the second and 1 400 in the third. 500 non-pregnant women were recruited as controls. Levels of serum thyrotrophin (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TG) were measured, and urinary iodine levels were detected by arsenic-cerium catalytic spectrophotometry. Results There were statistically significant differences between the pregnant groups and the control group in FT3, FT4, and TSH levels (P 0.05). Conclusions Iodine nutritional status was closely related to gestational age. Abnormal TSH levels were mainly observed in the second and third trimesters, abnormal serum levels of FT3, FT4, anti-TG and anti-TPO in the first trimester, and iodine deficiency in the third trimester. Thyroid function and urinary iodine should be monitored at each trimester during pregnancy. Key words: Pregnant women; Thyroid function tests; Reference interval; Urinary iodine

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乌鲁木齐市汉族孕妇甲状腺功能与碘营养状况的相关性

目的建立乌鲁木齐市孕妇甲状腺激素水平的参考区间，规范孕期甲状腺疾病的诊断标准，评价妊娠不同阶段的碘营养状况和甲状腺功能，为指导妇女补充碘提供依据。方法对2015年5月至2016年6月乌鲁木齐市3731名孕妇进行横断面调查。妊娠前期1 206头，妊娠中期1 125头，妊娠晚期1 400头。500名未怀孕的妇女被招募作为对照。测定血清促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、抗甲状腺过氧化物酶(anti-TPO)、抗甲状腺球蛋白(anti-TG)水平，采用砷铈催化分光光度法检测尿碘水平。结果妊娠组FT3、FT4、TSH水平与对照组比较，差异均有统计学意义(P < 0.05)。结论碘营养状况与胎龄密切相关。TSH水平异常主要见于妊娠中晚期，FT3、FT4、抗tg、抗tpo水平异常见于妊娠早期，碘缺乏见于妊娠晚期。甲状腺功能和尿碘应在怀孕期间的每个三个月监测。关键词:孕妇;甲状腺功能检查;参考区间;尿碘

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.