Effect of per oral sipermetrin exposure on serum 17 estradiol and uterine malondialdehyde (MDA) levels in female Wistar strain rats (Rattus norvegicus)

Abstract

Objective: This study aimed to verify the effect of oral siper-metrin exposure to decrease serum estradiol 17b levels and increased malondialdehyde (MDA) in the uterus level of female Wistar strain rats (Rattus norvegicus).Materials and Methods: The method of this study was true experimental post test only control group in vivo using 24 female rats, divided into 3 groups treated by administering a dose of 5, 10 and 20 mg/kg sipermetrin for 28 days and one control group. Then blood samples were taken from the heart for measurement of serum estradiol 17b levels by ELISA and uterine organs were taken for measurement of Malondialdehyde (MDA) with spectro-photometry method.Results: The results of the measurement of serum estradiol 17b and uterus malondialdehyde (MDA) levels of female Wistar strain rats (Rattus norvegicus) showed an opposite pattern, where there was a decline in serum estradiol 17b levels and an increase in uterus malondialdehyde (MDA) level. There was a significant difference (p=0.000

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每次口服西普美林对血清17的影响 雌性Wistar品系大鼠（褐家鼠）雌二醇和子宫丙二醛（MDA）水平的变化

目的：本研究旨在验证口服西伯胺对雌性Wistar品系大鼠（Rattus norvegicus）血清雌二醇17b水平降低和子宫内丙二醛（MDA）水平升高的影响。材料和方法：本研究的方法是真正的实验后体内对照组，使用24只雌性大鼠，分为3组和一个对照组，分别给予5、10和20mg/kg西普美林28天。然后取心脏血样，用ELISA法测定血清雌二醇17b水平，取子宫脏器，用分光光度法测定丙二醛（MDA）。结果：雌性Wistar品系大鼠（Rattus norvegicus）血清雌二醇17b和子宫丙二醛（MDA）水平的测定结果呈相反的模式，血清雌二醇17 b水平下降，子宫丙二醛（丙二醛）水平升高。雌性大鼠17b雌二醇血清和子宫丙二醛（MDA）水平在对照组和暴露于西普美林治疗28天的组之间存在显著差异（p=0.000<α）。结论：西普霉素可降低雌性Wistar品系大鼠血清雌二醇17b水平，增加子宫丙二醛（MDA）水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。