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Characteristics of outpatient gynecology oncology services before and after COVID-19 pandemic at Ulin Regional General Hospital, Banjarmasin, Indonesia 印度尼西亚班加马辛市乌林地区总医院2019冠状病毒病大流行前后妇科肿瘤门诊服务特点
Pub Date : 2023-08-29 DOI: 10.20473/mog.v31i22023.68-74
Setyo Teguh Waluyo, Ferry Armanza, Hariadi Yuseran, K. Halim
HIGHLIGHTSThe characteristics of gynecology oncology services at Ulin Regional General Hospital before and after the COVID-19 pandemic were evaluated.There was a decrease of 19% in the number of visits by Gynecology Oncology Clinic patients at Ulin Regional General Hospital between the period of March 2019 - February 2020 and March 2020 - February 2021. ABSTRACTObjective: The aim of this study was to investigate the characteristics of the Gynecology Oncology Outpatient Clinic at Ulin Hospital Banjarmasin before and after the COVID-19 pandemic.Materials and Methods: This descriptive study utilized existing patient data from the Gynecology Oncology Outpatient Clinic at Ulin Hospital Banjarmasin covering the period from March 2019 to February 2021. The study received ethical approval from the Ulin General Hospital ethics committee with clearance number 10/I-Reg Research/RSUDU/23. The collected data was presented in a tabular format to compare the service characteristics before the pandemic (March 2019 - February 2020) and after the pandemic (March 2020 – February 2021).Results: During the periods of March 2019 – February 2020 and March 2020 – February 2021, there was a reduction of 19% in patient visits. The number of patients undergoing treatment also decreased, from 1081 patients (53.9%) in the period of March 2019 – February 2020 to 926 patients (46.1%) in the period of March 2020 – February 2021. Notably, there was a decrease in the number of patients undergoing surgical procedures, dropping from 76 patients (70.4%) in the period of March 2019 – February 2020 to 32 patients (29.6%) in the period of March 2020 – February 2021. A similar trend was seen in patients receiving chemotherapy, with the count decreasing from 1005 patients (52.9%) in the period of March 2019 – February 2020 to 894 patients (47.1%) in the period of March 2020 – February 2021. These changes were attributed to various hospital measures implemented to address the COVID-19 pandemic, including a reduction in outpatient clinic visits and the temporary suspension of surgical procedures from March 2020 to October 2020 to minimize potential exposure.Conclusion: The study highlights a noticeable decline in both the frequency of visits to the Gynecology Oncology Outpatient Clinic at Ulin Regional General Hospital Banjarmasin and the number of patients receiving treatment during the periods before and after the onset of the COVID-19 pandemic. 
评价乌林地区总医院2019冠状病毒病疫情前后妇科肿瘤服务特点。2019年3月至2020年2月和2020年3月至2021年2月期间,乌林地区总医院妇科肿瘤门诊患者就诊次数减少了19%。摘要目的:了解新冠肺炎大流行前后班加马辛市乌林医院妇科肿瘤科门诊的特点。材料和方法:本描述性研究利用了Banjarmasin乌林医院妇科肿瘤门诊的现有患者数据,时间为2019年3月至2021年2月。该研究获得了乌林综合医院伦理委员会的伦理批准,批准号为10/I-Reg Research/RSUDU/23。收集的数据以表格形式呈现,以比较大流行前(2019年3月至2020年2月)和大流行后(2020年3月至2021年2月)的服务特征。结果:在2019年3月至2020年2月和2020年3月至2021年2月期间,患者就诊次数减少了19%。接受治疗的患者数量也有所减少,从2019年3月至2020年2月的1081例(53.9%)减少到2020年3月至2021年2月的926例(46.1%)。值得注意的是,接受外科手术的患者数量有所减少,从2019年3月至2020年2月的76名患者(70.4%)减少到2020年3月至2021年2月的32名患者(29.6%)。接受化疗的患者也出现了类似的趋势,从2019年3月至2020年2月的1005例(52.9%)减少到2020年3月至2021年2月的894例(47.1%)。这些变化归因于医院为应对COVID-19大流行而采取的各种措施,包括从2020年3月到2020年10月减少门诊就诊和暂时停止外科手术,以尽量减少潜在的接触。结论:该研究强调,在2019冠状病毒病大流行发生前后,乌林地区总医院Banjarmasin妇科肿瘤门诊就诊频率和接受治疗的患者人数均明显下降。
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引用次数: 0
Is maternal pre-pregnancy Body Mass Index associated with type of Congenital Heart Disease in offspring? 母亲孕前体重指数与后代先天性心脏病类型有关吗?
Pub Date : 2023-08-29 DOI: 10.20473/mog.v31i22023.80-85
Nofita Fachryandini, Taufiq Hidayat, E. Ernawati, M. A Rahman
HIGHLIGHTSThe most common CHD was atrial septal defect for acyanotic CHD and Tetralogy of Fallot for cyanotic CHD.There was no association between maternal pre-pregnancy BMI and type of CHD in offspring. ABSTRACTObjectives: This study aimed to determine the association between maternal pre-pregnancy BMI and type of congenital heart disease (CHD) in offspring.Materials and Methods: This retrospective cross-sectional study involved all mothers of children with CHD who visited Pediatric Outpatient Unit at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January to December 2019. The maternal data were obtained from the KIA's (Maternal and Child Health) book or through anamnesis by telephone, while the offspring’s data were collected from medical records. The data were analyzed using the Chi-Square test. Significance was determined at a 5% level (p <0.05).Results: We studied 117 mothers of children with CHD. The most frequent maternal pre-pregnancy body mass index (BMI) was normal (BMI 17-23 kg/m2) accounting for 56.4% of the study population. The most common CHD was atrial septal defect (33.3%) among acyanotic patients and Tetralogy of Fallot (8.5%) among cyanotic patients. The Chi-Square test showed p=0.958 for the association between maternal pre-pregnancy BMI and type of CHD in offspring.Conclusion: There was no association between maternal pre-pregnancy BMI and type of CHD in offspring. 
无紫型冠心病最常见的是房间隔缺损,紫绀型冠心病最常见的是法洛四联症。母亲孕前体重指数与后代冠心病类型没有关联。摘要目的:探讨孕妇孕前BMI与子代先天性心脏病(CHD)类型的关系。材料和方法:这项回顾性横断面研究涉及2019年1月至12月在印度尼西亚泗水Dr. Soetomo综合学术医院儿科门诊就诊的所有冠心病患儿母亲。母亲的数据从KIA(妇幼保健)的书中获得,或通过电话进行记忆,而后代的数据从医疗记录中收集。采用卡方检验对数据进行分析。在5%水平上具有显著性(p <0.05)。结果:对117例冠心病患儿的母亲进行了研究。最常见的孕妇孕前体重指数(BMI)为正常(BMI 17 ~ 23 kg/m2),占研究人群的56.4%。无紫绀患者最常见的冠心病是房间隔缺损(33.3%)和法洛四联症(8.5%)。经卡方检验,母体孕前BMI与子代冠心病类型的相关性p=0.958。结论:孕妇孕前体重指数与子代冠心病类型无相关性。
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引用次数: 0
The management of Monochorionic Monoamniotic (MCMA) twin pregnancy 单绒毛膜单羊膜(MCMA)双胎妊娠的处理
Pub Date : 2023-08-29 DOI: 10.20473/mog.v31i22023.103-109
E. Ernawati, Jihan Qonitatillah, A. Sulistyono
HIGHLIGHTSMonochorionic monoamniotic (MCMA) twin pregnancy has a significant risk of perinatal morbidity and mortality, including intrauterine fetal death (IUFD).The risk of prematurity, the risk of death due to MCMA complications, the availability of the NICU, also high costs on preterm care were factors in deciding to terminate the pregnancy.The ideal time to deliver monochorionic twins in order to reduce the risks of cord entanglement, growth discrepancies, and intrauterine fetal death is still a point of controversy.Early diagnosis, intensive antenatal monitoring, patient and family decision would contribute to antenatal mortality reduction. ABSTRACTObjectives: To present the management of monochorionic monoamniotic (MCMA) twin pregnancy.Case Report: Advanced prenatal treatment has improved the prognosis for Monochorionic Monoamniotic (MCMA) pregnancies; however, there is still no agreement on how to handle MCMA twins. The authors report 2 cases of monoamniotic monochorionic twin pregnancies. In the first case, a 30-years-old primi pregnant woman detected MCMA at 14 weeks of gestation; no complications related to MCMA were found; she planned delivery at 32 weeks, but one of the babies died in the womb at 31/32 weeks pregnant, a live baby born by cesarean section. The second case was a 36-year-old pregnant woman, on her third pregnancy, diagnosed with MCMA after 12 weeks of pregnancy, no complications related to MCMA, the baby was born at 32 weeks pregnant, and both babies survived. The management was the same in both cases, but different outcomes were obtained; in case 1, the baby died allegedly due to cord entanglement, which could not be detected during pregnancy.
单绒毛膜单羊膜(MCMA)双胎妊娠具有围产儿发病率和死亡率的显著风险,包括宫内胎儿死亡(IUFD)。早产风险、MCMA并发症导致的死亡风险、新生儿重症监护病房的可用性以及早产儿护理的高成本是决定终止妊娠的因素。为了减少脐带缠结、生长差异和宫内胎儿死亡的风险,单绒毛膜双胞胎的理想分娩时间仍然是一个有争议的问题。早期诊断、加强产前监测、患者和家庭决定将有助于降低产前死亡率。目的:探讨单绒毛膜单羊膜双胎妊娠的处理方法。病例报告:先进的产前治疗改善了单绒毛膜单羊膜妊娠(MCMA)的预后;然而,对于如何处理MCMA双胞胎,目前还没有达成一致。作者报告2例单羊膜单绒毛膜双胎妊娠。在第一例中,一名30岁的初孕妇女在妊娠14周时检测到MCMA;未发现与MCMA相关的并发症;她计划在32周分娩,但其中一个婴儿在怀孕31/32周时死在子宫里,这是一个通过剖宫产出生的活婴儿。第二例为36岁孕妇,第三次妊娠,妊娠12周后诊断为MCMA,无MCMA相关并发症,婴儿在妊娠32周出生,两名婴儿均存活。两种情况的处理方法相同,但结果不同;在案例1中,婴儿死亡据称是由于脐带缠绕,这在怀孕期间无法检测到。
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引用次数: 0
Description of the implementation of complementary therapy in midwifery services in Surabaya, Indonesia 印度尼西亚泗水助产服务补充疗法实施情况描述
Pub Date : 2023-08-29 DOI: 10.20473/mog.v31i22023.75-79
Annisa' Wigati Rozifa, Nova Elok Mardliyana, Irma Maya Puspita
HIGHLIGHTSMidwifery services are carried out by combining conventional and complementary midwifery servicesTypes of complementary therapies applied by 52% of independent midwifery services in Surabaya consisted of aromatherapy, hypnotherapy, herbal medicine, baby massage and spa, maternity massage, oxytocin massage, and yoga. ABSTRACTObjectives: This study aimed to describe the implementation of complementary therapy among the independent midwifery practices in Surabaya, Indonesia.Materials and Methods: Employing a quantitative approach with a survey methodology, this study involved data collection through surveys administered to independent midwives practicing in Surabaya and midwives affiliated with independent midwifery practices. The questionnaires were containing the characteristics of the participants, the implementation of complementary therapies, and the complementary therapies integrated into the practice settings.Results: The findings revealed that 25 midwives (comprising 52%) provided complementary midwifery services, whereas 23 midwives (comprising 48%) abstained from incorporating complementary midwifery services into their independent midwifery practices. The types of complementary therapies implemented consisted of aromatherapy, hypnotherapy, herbal medicine, baby massage and spa, maternity massage, oxytocin massage, and yoga.Conclusion: This study concluded that 52% of independent midwives in Surabaya applied complementary therapy into their practices. 
在泗水,52%的独立助产服务机构采用的辅助疗法类型包括芳香疗法、催眠疗法、草药、婴儿按摩和水疗、产妇按摩、催产素按摩和瑜伽。摘要:目的:本研究旨在描述印度尼西亚泗水独立助产实践中补充治疗的实施情况。材料和方法:采用定量方法和调查方法,本研究通过对泗水执业的独立助产士和独立助产实践附属助产士的调查收集数据。问卷内容包括参与者的特征、辅助治疗的实施情况以及辅助治疗与实践环境的结合情况。结果:调查结果显示,25名助产士(占52%)提供辅助助产服务,而23名助产士(占48%)放弃将辅助助产服务纳入其独立助产实践。补充疗法的类型包括芳香疗法、催眠疗法、草药、婴儿按摩和水疗、孕妇按摩、催产素按摩和瑜伽。结论:本研究得出结论,泗水52%的独立助产士在其实践中应用了补充疗法。
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引用次数: 0
The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks 妊娠41周以上口服米索前列醇与阴道米索前列醇的Bishop评分变化及分娩事件的差异
Pub Date : 2023-08-29 DOI: 10.20473/mog.v31i22023.61-67
Maskasoni Maskasoni, J. Dewantiningrum
HIGHLIGHTSOral misoprostol is more effective than vaginal misoprostol in cervical ripening as a part of induction of labor.Oral misoprostol is as safe as vaginal misoprostol. ABSTRACTObjective: To compare Bishop score changes and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks.Materials and Methods: A total of 52 pregnant women with more than 41 weeks of gestation, had a Bishop score less than 5, and were undergoing induction labor were randomly divided into two groups: oral and vaginal misoprostol. In the oral misoprostol group, participants were given 25 mg of misoprostol in a solution with a concentration of 1 ug/ml every 2 hours. In the vaginal misoprostol group, a 25 mg misoprostol tablet was inserted into the posterior fornix every 6 hours. The two groups were compared in terms of Bishop score during the first 6 hours, changes in Bishop score, labor at term events, neonatal outcomes, complications, and side effects after the administration of misoprostol.Results: The oral group showed significantly higher changes in Bishop score compared to the vaginal group (5.5 vs 3.6; p=0.0001). The median interval times for induction of labor at term, induction at stage II, and induction at birth were found to be shorter in the oral misoprostol group compared to the vaginal group (7.3 hours vs 10.6 hours, 14.0 hours vs 16.8 hours, and 14.6 hours vs 17.6 hours; p=0.002, 0.003, 0.002). Labor at term occurred much more frequently in the oral group (53.8% vs 15.4%). Additionally, the oral misoprostol group had a 3.5 times higher likelihood of experiencing labor at term within the first 6 hours after the initial administration compared to the vaginal group (OR 3.5, 95% CI 1.33-9.23).Conclusion: Oral administration of misoprostol for cervical ripening has been demonstrated to be more effective than vaginal administration, greater bishop score changes while maintaining an equivalent level of safety.
作为引产的一部分,口服米索前列醇比阴道米索前列醇在宫颈成熟中更有效。口服米索前列醇和阴道使用米索前列醇一样安全。目的:比较妊娠41周以上口服和阴道米索前列醇的Bishop评分变化和产程事件。材料与方法:选取52例妊娠41周以上、Bishop评分小于5分的引产孕妇,随机分为口服和阴道米索前列醇两组。在口服米索前列醇组,每2小时给予25毫克米索前列醇溶液,浓度为1微克/毫升。阴道使用米索前列醇组,每6小时将米索前列醇片25 mg插入后穹窿。比较两组在使用米索前列醇后前6小时的Bishop评分、Bishop评分变化、足月分娩事件、新生儿结局、并发症和副作用。结果:口服组Bishop评分变化明显高于阴道组(5.5 vs 3.6;p = 0.0001)。与阴道组相比,口服米索前列醇组足月引产、II期引产和出生时引产的中位数间隔时间更短(7.3小时vs 10.6小时,14.0小时vs 16.8小时,14.6小时vs 17.6小时);P =0.002, 0.003, 0.002)。口腔组足月产程发生率更高(53.8% vs 15.4%)。此外,口服米索前列醇组在首次给药后6小时内发生足月分娩的可能性是阴道组的3.5倍(OR 3.5, 95% CI 1.33-9.23)。结论:口服米索前列醇用于宫颈成熟已被证明比阴道给药更有效,bishop评分变化更大,同时保持同等水平的安全性。
{"title":"The difference of Bishop score change and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks","authors":"Maskasoni Maskasoni, J. Dewantiningrum","doi":"10.20473/mog.v31i22023.61-67","DOIUrl":"https://doi.org/10.20473/mog.v31i22023.61-67","url":null,"abstract":"HIGHLIGHTS\u0000\u0000Oral misoprostol is more effective than vaginal misoprostol in cervical ripening as a part of induction of labor.\u0000Oral misoprostol is as safe as vaginal misoprostol.\u0000\u0000 \u0000ABSTRACT\u0000Objective: To compare Bishop score changes and labor event between oral and vaginal misoprostol in pregnancy beyond 41 weeks.\u0000Materials and Methods: A total of 52 pregnant women with more than 41 weeks of gestation, had a Bishop score less than 5, and were undergoing induction labor were randomly divided into two groups: oral and vaginal misoprostol. In the oral misoprostol group, participants were given 25 mg of misoprostol in a solution with a concentration of 1 ug/ml every 2 hours. In the vaginal misoprostol group, a 25 mg misoprostol tablet was inserted into the posterior fornix every 6 hours. The two groups were compared in terms of Bishop score during the first 6 hours, changes in Bishop score, labor at term events, neonatal outcomes, complications, and side effects after the administration of misoprostol.\u0000Results: The oral group showed significantly higher changes in Bishop score compared to the vaginal group (5.5 vs 3.6; p=0.0001). The median interval times for induction of labor at term, induction at stage II, and induction at birth were found to be shorter in the oral misoprostol group compared to the vaginal group (7.3 hours vs 10.6 hours, 14.0 hours vs 16.8 hours, and 14.6 hours vs 17.6 hours; p=0.002, 0.003, 0.002). Labor at term occurred much more frequently in the oral group (53.8% vs 15.4%). Additionally, the oral misoprostol group had a 3.5 times higher likelihood of experiencing labor at term within the first 6 hours after the initial administration compared to the vaginal group (OR 3.5, 95% CI 1.33-9.23).\u0000Conclusion: Oral administration of misoprostol for cervical ripening has been demonstrated to be more effective than vaginal administration, greater bishop score changes while maintaining an equivalent level of safety.","PeriodicalId":52893,"journal":{"name":"Majalah Obstetri dan Ginekologi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84836756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of micronutrients on postpartum pelvic organ prolapse patients 微量营养素对产后盆腔器官脱垂患者的影响
Pub Date : 2023-08-29 DOI: 10.20473/mog.v31i22023.92-96
Rahajeng Mukhamad, Muhammad Nooryanto, Dzikrifishofa, Article Info
HIGHLIGHTSSerum vitamin D levels were significantly different between POP and in healthy women.Micronutrient MMP-1 expression is increased in POP patients. ABSTRACTObjective: Pelvic Organ Prolapse (POP) is when pelvic tissues sink into the vagina due to weakened ligaments or muscles. POP is common globally. Adequate nutrition, including Vitamin D, is vital for prevention. Vitamin D maintains bone and muscle health, regulates MMP-9 to control collagen, essential for pelvic support. Increased MMPs lead to collagen breakdown and POP. Recognizing vitamin D's role in collagen and POP is crucial for prevention. This study aimed to determine definitive association between vitamin D, collagen type I and MMP-1 in POP patients.Materials and Methods: Our search yielded 1375 studies, of which 7 were included in the present investigation. Two studies addressed the micronutrient status of vitamin D, four investigated the micronutrient status of type 1 collagen, and two studied the micronutrient status of MMP-1 in postpartum POP patients.Results: The results showed that the mean of vitamin D levels from POP group was substantially decreased compared to a those of healthy women in the control group (95% confidence interval (CI), -3.64; -3.44 and p <0.05). There was a decrease of collagen I protein in POP (95% CI, -3.26; -2.45. p <0.05). Additionally, MMP-1 expression increased in POP patient (95% CI. 1.48-2.23, p <0.05)Conclusion: Micronutrient status was severely compromised in POP group compared to control subjects.
血清维生素D水平在POP和健康女性之间有显著差异。微量营养素MMP-1表达在POP患者中升高。摘要:目的:盆腔器官脱垂(POP)是指由于韧带或肌肉减弱导致盆腔组织下沉到阴道内。POP在全球都很普遍。充足的营养,包括维生素D,对预防至关重要。维生素D维持骨骼和肌肉健康,调节MMP-9以控制胶原蛋白,对骨盆支持至关重要。增高的MMPs会导致胶原蛋白分解和POP。认识到维生素D在胶原蛋白和POP中的作用对预防至关重要。本研究旨在确定POP患者维生素D、I型胶原蛋白和MMP-1之间的确切关系。材料和方法:我们检索了1375项研究,其中7项纳入了本研究。两项研究研究了维生素D的微量营养素状况,四项研究了1型胶原蛋白的微量营养素状况,两项研究了产后POP患者MMP-1的微量营养素状况。结果:结果显示,与对照组健康女性相比,POP组维生素D水平的平均值显著降低(95%置信区间(CI), -3.64;-3.44, p <0.05)。POP中I型胶原蛋白减少(95% CI, -3.26;-2.45。p < 0.05)。此外,MMP-1表达在POP患者中升高(95% CI)。(1.48-2.23, p <0.05)结论:与对照组相比,POP组微量营养素状况严重受损。
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引用次数: 0
Testosterone and sexual function in menopausal women based on the Female Sexual Function Index (FSFI) score 基于女性性功能指数(FSFI)评分的绝经妇女睾酮和性功能
Pub Date : 2023-08-29 DOI: 10.20473/mog.v31i22023.86-91
Muhammad Agung Khoiri, M. F. G. Siregar, S. Lumbanraja, I. H. Effendi, Yudha Sudewo, E. Ardiansyah, P. Eyanoer
HIGHLIGHTSTestosterone level correlates with FSFI score, showing that sexual function correlates with hormonal physiology.FSFI is a valid and useful tool in measuring sexual function. ABSTRACTObjective: This research aimed to analyze the correlation between testosterone levels and sexual function in postmenopausal women.Materials and Methods: This research was a descriptive observational study with a case series approach conducted at Aras Kabu Health Center Outpatient Polyclinic from May to August 2022. The normality test was carried out using the Shapiro-Wilk test. If the data were not normally distributed, data would be analyzed using the Spearman correlation test. If the data were normally distributed, the data analysis would use the Pearson correlation test.Results: There was a significant relationship between Female Sexual Function Index (FSFI) score with testosterone levels and duration of menopause with p<0.05. The degree of correlation found was 0.619 between testosterone levels and FSFI scores, indicating a moderate and significant positive correlation. A correlation degree of 0.482 was found between FSFI and length of menopause which indicated a significant moderate positive correlation, while the degree of correlation between testosterone levels and length of menopause was found to be 0.711, showing a strong and significant positive correlation.Conclusion: There is a significant relationship between FSFI scores with testosterone levels and duration of menopause as well. There was also a significant relationship between testosterone levels and the duration of menopause.
睾酮水平与FSFI评分相关,表明性功能与激素生理相关。FSFI是测量性功能的有效和有用的工具。摘要目的:探讨绝经后妇女睾酮水平与性功能的关系。材料和方法:本研究是一项描述性观察性研究,采用病例系列方法,于2022年5月至8月在Aras Kabu卫生中心门诊综合诊所进行。正态性检验采用Shapiro-Wilk检验。如果数据不是正态分布,则使用Spearman相关检验对数据进行分析。如果数据是正态分布,则使用Pearson相关检验进行数据分析。结果:女性性功能指数(FSFI)评分与睾酮水平、绝经时间有显著相关,p<0.05。睾酮水平与FSFI评分的相关程度为0.619,呈中度显著正相关。FSFI与绝经期长度的相关程度为0.482,呈显著的中度正相关;睾酮水平与绝经期长度的相关程度为0.711,呈强而显著的正相关。结论:FSFI评分与睾酮水平及绝经时间有显著相关。睾酮水平和更年期持续时间之间也有显著的关系。
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引用次数: 0
Impact of COVID-19 on the histopathological aspect of the placenta during pregnancy COVID-19对妊娠期间胎盘组织病理学的影响
Pub Date : 2023-08-29 DOI: 10.20473/mog.v31i22023.97-102
Anak Agung Ngurah, Jaya Kusuma, Article Info
The coronavirus disease 2019 (COVID-19) is still classified as a world pandemic. This disease can affect numerous systems of the human body. Pregnant women are classified as a vulnerable group since COVID-19 can cause high morbidity and mortality. Angiotensin-converting enzyme-2 (ACE-2) acts as a COVID-19 receptor, and this receptor is also present in the placenta. The placenta plays a significant part in the fetus, especially protecting it from harmful conditions. Since only a few studies are available, COVID-19’s influence on the placenta in pregnancy needs to be discussed further. The SARS-CoV-2-infected pregnant woman’s placenta showed histopathological alterations. Viral particles were detected on syncytiotrophoblast and chorionic villi vascular endothelial cells. Some studies show inflammatory conditions are not prominent in SARS-CoV-2 positive infection. This, perhaps due to the placenta’s immunological reaction, plays a significant role. The SARS-CoV-2 disorder tends to cause abnormalities within the placental tissue. Fetal vascular malperfusion (FVM) and maternal vascular malperfusion (MVM) are the most frequent findings from the studies included.
2019冠状病毒病(COVID-19)仍被列为世界大流行。这种疾病可以影响人体的许多系统。由于COVID-19可导致高发病率和死亡率,孕妇被列为弱势群体。血管紧张素转换酶-2 (ACE-2)作为COVID-19受体,这种受体也存在于胎盘中。胎盘在胎儿中起着重要的作用,尤其是保护胎儿免受有害环境的影响。由于只有少数研究可获得,COVID-19对妊娠期胎盘的影响需要进一步讨论。感染sars - cov -2的孕妇胎盘出现组织病理学改变。在合胞滋养细胞和绒毛膜绒毛血管内皮细胞上检测到病毒颗粒。一些研究表明,在SARS-CoV-2阳性感染中,炎症状况并不突出。这可能是由于胎盘的免疫反应,起着重要作用。SARS-CoV-2疾病往往会导致胎盘组织内的异常。胎儿血管灌注不良(FVM)和母体血管灌注不良(MVM)是研究中最常见的发现。
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引用次数: 0
Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia 异常子宫出血(AUB)在哈吉亚当马利克综合医院,棉兰,北苏门答腊,印度尼西亚
Pub Date : 2023-04-27 DOI: 10.20473/mog.v31i12023.30-35
Putri Ardina Sari Nainggolan, M. Rusda, Dwi Faradina, A. D. Lubis
HIGHLIGHTSLeiomyoma is still the most common case in women aged 41–50 years.Women who have an obese BMI are the main risk factor for abnormal uterine bleeding, so it is urged for women to maintain an ideal weight because it can be bad for health. ABSTRACTObjective: This study identified the incidence of Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, Indonesia, in 2020-2021.Materials and Methods: This was a descriptive study with a cross-sectional design. Sampling was taken using total sampling and using retrospective data in the form of medical records with a diagnosis of AUB at Haji Adam Malik General Hospital Medan in 2020–2021.Results: There were 197 cases of AUB, with the highest distribution in the age group of 41–50 years with 84 people (42.6%). The most cases of AUB with an obese BMI were 91 people (46.2%), married status as many as 176 people (89.3%), had the last education level of senior high school as many as 99 people (50.3%), 144 people (73.1%) got their first menstruation when they were >12 years old, 80 people (40.6%) had multiparity, 90 people (45.7%) received medical therapy. Based on the PALM-COEIN classification, the most AUB cases were AUB-L with 99 people (50.3%). Based on the classification of AUB-L locations, most locations were submucosa with 38.6%.Conclusion: AUB-L cases were still the most common cases at Haji Adam Malik General Hospital, Medan, Indonesia, in 2020–2021.
重点:平滑肌瘤仍然是41-50岁女性最常见的病例。体重指数过高的女性是子宫异常出血的主要危险因素,因此女性应保持理想体重,因为这可能对健康有害。摘要:目的:了解2020-2021年印尼棉兰Haji Adam Malik总医院异常子宫出血(AUB)的发生率。材料和方法:这是一项横断面设计的描述性研究。2020-2021年在棉兰哈吉亚当马利克综合医院,采用总抽样和以诊断为AUB的病历形式的回顾性数据进行抽样。结果:AUB 197例,以41 ~ 50岁年龄段分布最多,84例(42.6%)。体重指数为肥胖的AUB患者最多91人(46.2%),已婚176人(89.3%),最低学历为高中99人(50.3%),>12岁第一次月经144人(73.1%),多胎80人(40.6%),接受药物治疗90人(45.7%)。根据PALM-COEIN分类,AUB病例以AUB- l型最多,99例(50.3%)。根据AUB-L的位置分类,以粘膜下层居多,占38.6%。结论:2020-2021年,印尼棉兰Haji Adam Malik总医院的AUB-L病例仍是最常见的病例。
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引用次数: 0
The success rate of intrauterine insemination in sperm preparation swim-up method at room temperature compared to the incubator temperature 常温下精子准备游泳法与培养箱温度下的人工授精成功率比较
Pub Date : 2023-04-27 DOI: 10.20473/mog.v31i12023.11-16
Eriana Melinawati, Uki Retno Budihastuti, M. Pangestu, Teguh Prakosa, Affi Angelia Ratnasari, A. Laqif, Darto, Cahyono Hadi, Lunardhi Susanto, Metanolia Sukmawati, Rakano Kautsar Dwiyana, Alfi Marita Tristiarti, Abida Zuhra Jatiningtyas
HIGHLIGHTSThere were no significant differences in TMSC, sperm motility, sperm morphology, and DFI in sperm preparation using the swim-up method at 27°C and 37°C. However, this study provided an overview of the average improvement of DFI at 27°C compared to 37°C.There was no significant difference in the pregnancy rate of IUI in sperm preparation using the swim-up method at 27°C and 37°C. ABSTRACTObjective: This study aimed to determine the effect of temperature during sperm preparation on total sperm motile count (TMSC), sperm motility, sperm morphology, DNA fragmentation index (DFI), and pregnancy rate.Materials and Methods: A quasi-experimental laboratory study with pre- and post-test control group was conducted at Sekar Fertility Clinic, Dr. Moewardi General Hospital, Surakarta, Indonesia. A total of 20 sperm samples from infertile patients were prepared using the swim-up method at 27°C (group 1) and 37°C (group 2). TMSC, motility, morphology, and DFI examinations were performed. In addition, IUI was performed to confirm pregnancy rate. Sperm DNA fragmentation was determined using Sperm Chromatin Dispersion/SpermFunc DNAf test. Sperm DNA fragmentation was characterized by a halo <30% of the volume of the sperm head.Results: Group 1 had mean TMSC of 13.77 ± 9.30, while group 2 had 14.82 ± 8.82; p=0.218. Group 1 had a motility value 82.25+12.77 and group 2 had 82.55 ± 11.69; p=0.968. The morphological value for group 1 was 11.25 ± 5.15 and group 2 was 11.6 ± 5.34; p=0.626. The mean DFI for group 1 was 17.79 ± 10.88 and group 2 was 18.18 ± 12.95; p=0.765. Pregnancy rate in group 1 was 10% and group 2 was 20%; p=1.000.Conclusion: There were no significant differences in TMSC, sperm motility, sperm morphology, DFI, and pregnancy rate in sperm preparation using the swim-up method at 27°C and 37°C.
在27°C和37°C条件下,游泳法制备的精子在TMSC、精子活力、精子形态和DFI方面无显著差异。然而,本研究提供了27°C与37°C相比DFI平均改善的概述。在27°C和37°C条件下,游泳法制备精子的IUI受孕率无显著差异。摘要目的:研究精子制备过程中温度对精子总运动数(TMSC)、精子活力、精子形态、DNA片段化指数(DFI)和妊娠率的影响。材料和方法:在印度尼西亚苏拉arta的Dr. Moewardi总医院Sekar生育诊所进行了一项准实验实验室研究,其中包括测试前和测试后对照组。在27℃(第1组)和37℃(第2组)条件下,采用游泳法制备20例不孕症患者精子样本。进行TMSC、运动性、形态学和DFI检查。并行宫内人工授精,确认妊娠率。采用精子染色质分散/精子功能DNA检测测定精子DNA片段。精子DNA断裂的特征是光环<精子头体积的30%。结果:组1平均TMSC为13.77±9.30,组2平均TMSC为14.82±8.82;p = 0.218。组1的运动值为82.25±12.77,组2的运动值为82.55±11.69;p = 0.968。组1的形态学值为11.25±5.15,组2的形态学值为11.6±5.34;p = 0.626。组1平均DFI为17.79±10.88,组2平均DFI为18.18±12.95;p = 0.765。1组妊娠率为10%,2组妊娠率为20%;p = 1.000。结论:在27°C和37°C条件下,游泳法制备的精子在TMSC、精子活力、精子形态、DFI和妊娠率方面均无显著差异。
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引用次数: 0
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Majalah Obstetri dan Ginekologi
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