Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES Arquivo Brasileiro De Medicina Veterinaria E Zootecnia Pub Date : 2023-03-01 DOI:10.1590/1678-4162-12445

P. Santi, M. R. França, M. Milistetd

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Abstract

ABSTRACT Immunomediated thrombocytopenia is a systemic metabolic disorder in which the platelet count falls below reference values, as the patient's immune system destroys them. The main clinical signs in thrombocytopenia are petechial, hemorrhages, ecchymoses and suffusions. Hematomas can also occur in coagulation disorders. The diagnosis is based on clinical findings and hematological examinations. The treatment consists of the use of corticosteroids and immunosuppressants, delaying cell destruction, and may last for months, not always obtaining a cure for the disease. The present work reports the use of therapy with allogeneic mesenchymal stem cells, derived from the adipose tissue of dogs, for the treatment of chronic immunomediated thrombocytopenia, with an evolution of more than one year, in a Pinscher dog. The alternative treatment showed a good evolution, keeping platelets within the reference values during the treatment, giving the patient quality of life and removing the need for continuous medication for homeostasis after treatment.

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间质干细胞治疗犬慢性免疫介导性血小板减少症1例报告

免疫介导性血小板减少症是一种全身性代谢紊乱，患者的免疫系统破坏血小板计数，导致血小板计数低于参考值。血小板减少症的主要临床症状是瘀点、出血、淤血和充血。血肿也可发生在凝血障碍中。诊断依据临床表现和血液学检查。治疗包括使用皮质类固醇和免疫抑制剂，延缓细胞破坏，可能持续数月，并不总是能治愈疾病。目前的工作报告使用同种异体间充质干细胞，从狗的脂肪组织，用于治疗慢性免疫介导的血小板减少症，与一年多的进化，在一只平雪犬。替代治疗显示出良好的发展，在治疗期间将血小板保持在参考值内，使患者的生活质量得到改善，并且在治疗后不再需要持续用药来维持体内平衡。

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来源期刊

Arquivo Brasileiro De Medicina Veterinaria E Zootecnia 农林科学-兽医学

CiteScore

0.80

自引率

25.00%

发文量

111

审稿时长

9-18 weeks

期刊介绍： Publica artigos originais de pesquisa sobre temas de medicina veterinária, zootecnia, tecnologia e inspeção de produtos de origem animal e áreas afins relacionadas com a produção animal. Atualmente a revista mantém 628 permutas (419 internacionais e 209 nacionais), sendo um verdadeiro suporte para o recebimento de periódicos pela Biblioteca da Escola. A partir de 1999, a Escola de Veterinária delegou à FEP MVZ Editora o encargo do gerenciamento e edição de todas suas publicações, inclusive do Arquivo, ficando somente com o apoio logístico (instalações, equipamentos, pessoal etc.). O apoio financeiro é exercido pelo CNPq/FINEP e pela própria FEP MVZ.