A Sensitive Sensor for Nano-Molar Detection of 5-Fluorouracil by Modifying a Paste Sensor with Graphene Quantum Dots and an Ionic Liquid

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY Journal of Nanostructures Pub Date : 2020-04-01 DOI:10.22052/JNS.2020.02.004

R. Emamian, M. Ebrahimi, H. Karimi-Maleh

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引用次数: 8

Abstract

5-fluorouracil is a widely used anticancer drug with many side effects on humans, and hence its analysis in biological samples is very important. Accordingly, a novel sensitive electrochemical approach was fabricated by incorporating graphene quantum dots (GCD) and 1-butylpyridinium bromide (BPBr) in the formulation of a carbon paste electrode (GQD/BPBr/CPE). The GQD was synthesized and characterized TEM method and results confirmed them as being spherical with D~ of 5.0 nm. The applicability of the GQD/BPBr/CPE in voltammetric analysis of 5-fluorouracil was evaluated. The relations of oxidation currents and potentials of 5-fluorouracil with pH at the surface of GQD/BPBr/CPE were investigated and the results confirmed the involvement of electrons and protons in the electro-oxidation mechanism of 5-fluorouracil. In square wave voltammetry (SWV) analyses, the GQD/BPBr/CPE showed good sensitivity for 5-fluorouracil over a wide linear range of 0.001–400 μΜ and a detection limit of 0.5 nΜ was achieved. The GQD/BPBr/CPE was successfully applied for the determination of 5-fluorouracil in pharmaceutical samples and acceptable results were obtained.

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用石墨烯量子点和离子液体修饰膏体传感器制备5-氟尿嘧啶纳米摩尔检测灵敏传感器

5-氟尿嘧啶是一种广泛使用的抗癌药物，对人体有许多副作用，因此对其在生物样品中的分析非常重要。因此，将石墨烯量子点(GCD)和1-丁基溴化吡啶(BPBr)结合在碳糊电极(GQD/BPBr/CPE)中，制备了一种新的敏感电化学方法。合成了GQD并对其进行了TEM表征，结果表明GQD为球形，D~为5.0 nm。评价了GQD/BPBr/CPE法在5-氟尿嘧啶伏安分析中的适用性。研究了5-氟尿嘧啶在GQD/BPBr/CPE表面的氧化电流和氧化电位与pH的关系，证实了电子和质子参与5-氟尿嘧啶的电氧化机理。在方波伏安法(SWV)分析中，GQD/BPBr/CPE对5-氟尿嘧啶具有良好的灵敏度，线性范围为0.001 ~ 400 μΜ，检出限为0.5 nΜ。将GQD/BPBr/CPE法应用于药品样品中5-氟尿嘧啶的测定，取得了满意的结果。

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来源期刊

Journal of Nanostructures NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： Journal of Nanostructures is a medium for global academics to exchange and disseminate their knowledge as well as the latest discoveries and advances in the science and engineering of nanostructured materials. Topics covered in the journal include, but are not limited to the following: Nanosystems for solar cell, energy, catalytic and environmental applications Quantum dots, nanocrystalline materials, nanoparticles, nanocomposites Characterization of nanostructures and size dependent properties Fullerenes, carbon nanotubes and graphene Self-assembly and molecular organization Super hydrophobic surface and material Synthesis of nanostructured materials Nanobiotechnology and nanomedicine Functionalization of nanostructures Nanomagnetics Nanosensors.