Formulation and release kinetics of ibuprofen–bentonite tablets

IF 1.1 4区地球科学 Q4 CHEMISTRY, PHYSICAL Clay Minerals Pub Date : 2022-09-01 DOI:10.1180/clm.2022.35

Jamal Alyoussef Alkrad, Sind Al-Sammarraie, E. Dahmash, N. Qinna, A. Naser

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引用次数: 1

Abstract

Abstract Bentonite-based tablets offer multiple advantages over other types of formulated tablets, including being biocompatible and cost-effective, and they can be used to develop gel-like matrices that have potential for use in sustained-release formulations. Developing a high-load sustained-release formulation has been reported to be challenging; therefore, the aim of this study was to develop systematically bentonite-based sustained-release tablets for a high-load active agent (ibuprofen) and investigate their release kinetics. Ibuprofen-loaded tablets (800 mg) were prepared using wet and dry granulation followed by enteric coating of the tablets. Fourier-transform infrared spectroscopy, differential scanning calorimetry and X-ray powder diffraction were used to evaluate the compatibility of ibuprofen with bentonite. The results show that these tablets comply with compendial requirements. In addition, the release profile of the formulations reveals that the drug follows a non-Fickian release model. The present formulation demonstrates a new use of bentonite as a safe and cost-effective excipient with adequate binding and compaction for preparing sustained-release tablets.

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布洛芬-膨润土片的配方及释放动力学

摘要膨润土基片剂与其他类型的配方片剂相比具有多种优势，包括生物相容性和成本效益，它们可用于开发具有缓释制剂潜力的凝胶状基质。据报道，开发一种高负荷缓释制剂具有挑战性；因此，本研究的目的是系统开发用于高负荷活性剂（布洛芬）的膨润土基缓释片，并研究其释放动力学。使用湿法和干法制粒，然后肠溶包衣制备布洛芬负载片剂（800mg）。采用傅立叶变换红外光谱、差示扫描量热法和X射线粉末衍射法对布洛芬与膨润土的相容性进行了评价。结果表明，这些片剂符合药典要求。此外，制剂的释放曲线表明，该药物遵循非菲克释放模型。本制剂展示了膨润土作为一种安全且具有成本效益的赋形剂的新用途，该赋形剂具有足够的结合和压实作用，可用于制备缓释片。

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来源期刊

Clay Minerals 地学-矿物学

CiteScore

3.00

自引率

20.00%

发文量

审稿时长

6 months

期刊介绍： Clay Minerals is an international journal of mineral sciences, published four times a year, including research papers about clays, clay minerals and related materials, natural or synthetic. The journal includes papers on Earth processes soil science, geology/mineralogy, chemistry/material science, colloid/surface science, applied science and technology and health/ environment topics. The journal has an international editorial board with members from fifteen countries.