Interleukin 6 Levels and their Correlation with Various Hematological and Biochemical Parameters in Covid-19 Patients

Abstract

Background: coronavirus 19 is a beta-coronavirus, enveloped and roughly spherical with approximately 60 to 140 nm in diameter with positive-sense single-stranded RNA genome. Objectives: Measurement of interleukin 6 (IL6) level in a group of patients with confirmed Covid19 infection and its correlation with many hematological and  biochemical parameters , mainly lymphocyte , neutrophil  count and their ratio , platelet count , serum ferritin , C reactive protein as well as D-dimer level Subjects and Methods: This study was conducted on 60 PCR positive patients variably affected by COVID-19 , cases collected sequentially from June till November 2021 from Medical City hospital (Private Nursing hospital/ Intensive Care Unit (ICU)) with outpatient mild cases collection. Results: IL-6  levels  showed a significant difference between the mild-moderate groups (p 0.001) and the mild- severe groups (p 0.009) ; additionally, there was significant  statistical correlation between IL-6 and the other parameters included  in the study. Conclusions: IL6 level was highly elevated in most of  moderately and severely affected COVID 19 patients ,It's level correlates well with the most important hematological  and inflammatory parameters that enable it to be used as a marker to assess the severity of the infection and for following up patients.