Genetican Alysis of the Role of Connexin 37 Polymorphism in Spontaneous Abortion

Abstract

Introduction: Among unique cardiovascular risk factors in women are complications during pregnancy,including miscarriage. Important risk factor is also genetic background. One of powerful candidate genesfor cardiovascular disease of atherosclerotic origin (aCVD) is gene for connexin 37 (Cx37) with stronggene-environment interaction including smoking status, that is also strong risk factor for complications inpregnancy including spontaneous abortion (SA). Material and Methods: We analysed association betweenSA and Cx37 gene polymorphism (1019C>T; Pro319Ser) in 547 foetuses and its potential interaction withsmoking status of mothers. Using genetic analyses from women from general population as controls, ORsfor T allele, found in our previous studies to be protective against a CVD, were calculated. This study wasa secondary analysis of a randomized controlled trial. Results and Conclusion: T allele carriers (foetuses),had OR 0.91 (95 % CI 0.72-1.14) and no interaction with smoking was observed. In conclusion, no significantassociation between Cx37 polymorphism and SA was observed and no modifying effect of smoking statuson this association was detected.