Co-ingestion with γ-cyclodextrin improves bioavailability of α-linolenic acid in Perilla frutescens seed oil

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2023-01-10 DOI:10.1016/j.fhfh.2023.100116

Keisuke Yoshikiyo , Miho Takahashi , Yu Narumiya , Mikito Honda , Keita Iwasaki , Mika Ishigaki , Edward G. Nagato , Hemanth Noothalapati , Hidehisa Shimizu , Kaeko Murota , Tatsuyuki Yamamoto

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引用次数: 3

Abstract

The present study aimed to determine the effects of ingesting perilla oil derived from the seeds of Perilla frutescens as an inclusion complex with γ-cyclodextrin (γ-CD) in a six-week study, and to elucidate the role of γ-CD in the assimilation of perilla oil. Plasma α-linolenic acid (18:3n-3) levels were significantly higher in rats fed a diet containing this inclusion complex compared to those fed the same amount of perilla oil without γ-CD, indicating that γ-CD enhances perilla oil bioavailability. An in vitro analysis of lipolysis revealed that perilla oil was more resistant to porcine pancreatic lipase than soybean oil, a commonly used lipid source in animal diets. However, adding γ-CD accelerated perilla oil lipolysis, which may explain the elevated 18:3n-3 plasma levels in rats fed the inclusion complex. These findings suggest a more efficient way to increase physiological levels of 18:3n-3 and longer n-3 fatty acids when ingesting perilla oil.

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与γ-环糊精共食可提高紫苏籽油中α-亚麻酸的生物利用度

本研究以紫苏籽为原料，以γ-环糊精(γ-CD)包合物的形式摄入紫苏油，研究了γ-CD在紫苏油同化过程中的作用。与不添加γ-CD的大鼠相比，添加该包合物的大鼠血浆α-亚麻酸(18:3n-3)水平显著升高，表明γ-CD提高了紫苏油的生物利用度。一项体外脂肪分解分析表明，紫苏油比大豆油更能抵抗猪胰腺脂肪酶，大豆油是动物饲料中常用的脂肪来源。然而，添加γ-CD加速了紫苏油的脂肪分解，这可能解释了喂食包合物的大鼠血浆中18:3n-3水平升高的原因。这些发现表明，在摄入紫苏油时，有一种更有效的方法可以提高18:3n-3和更长n-3脂肪酸的生理水平。

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