Asymmetry in icosahedral viruses

IF 5.7 2区 医学 Q1 VIROLOGY Current opinion in virology Pub Date : 2022-06-01 DOI:10.1016/j.coviro.2022.101230
Joyce Jose , Susan L. Hafenstein
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引用次数: 3

Abstract

Asymmetric structural elements are typically not readily visualized in icosahedral viruses that have other obvious symmetrical features and most asymmetry has gone unresolved for decades. Asymmetric features may be incorporated during assembly or maturation or develop during key steps in the infectious cycle of the virus. However, resolving asymmetric features requires abandoning capsid-wide symmetry averaging and relying on special applications during single-particle cryogenic electron microscopy (cryo-EM) analysis. Thanks to the advances in the cryo-EM field, we are learning more about asymmetry of viruses. Here we summarize some of what is currently known about asymmetric structural features using as examples members of the Togaviridae, Flaviviridae, Herpesviridae, Parvoviridae, and Papillomaviridae.

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二十面体病毒的不对称性。
在二十面体病毒中,不对称结构元素通常不容易被发现,因为它们具有其他明显的对称特征,而且大多数不对称几十年来一直没有得到解决。不对称特征可能在病毒的组装或成熟过程中被纳入,或在病毒感染周期的关键步骤中形成。然而,解决不对称特征需要放弃衣壳范围的对称平均,并依赖于单粒子低温电子显微镜(cryo-EM)分析中的特殊应用。由于低温电镜技术的进步,我们对病毒的不对称性有了更多的了解。在这里,我们以托加病毒科、黄病毒科、疱疹病毒科、细小病毒科和乳头瘤病毒科为例,总结了一些目前已知的不对称结构特征。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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