Nicotine Differentially Modulates Emotional-Locomotor Interactions for Adult or Adolescent Rats

Q2 Social Sciences Revista Colombiana de Psicologia Pub Date : 2022-01-20 DOI:10.15446/rcp.v31n1.89822

Carlos Novoa, José L. Solano, Hans Ballesteros-Acosta, M. Lamprea, Leonardo A. Ortega

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引用次数: 2

Abstract

Previous research has shown that exposure to nicotine and other drugs of abuse stimulate dopaminergic neurons in the mesolimbic circuit. Sustained activation of this circuit by prolonged exposure to drugs promotes locomotor sensitization. However, there are inconsistent reports about nicotine-induced locomotor sensitization when assessed among different developmental stages. We evaluated exploratory behavior on specific areas of the open field as an indicator of behavioral disinhibition and general locomotor activity as an indicator of nicotine-induced locomotor sensitization, to further explore the mechanisms underlying behavioral adaptations to nicotine exposure in animals from different developmental stages. We found that while adolescent and adult rats are equally responsive to nicotine-induced locomotor sensitization, nicotine disrupts inhibition of risk-related behavior only in adolescent rats. Together, our results suggest that chronic daily exposure to nicotine promotes potentiation of its stimulant effects on locomotor activity. In adolescents, this effect is accompanied by a decreased capacity to inhibit risk-related behaviors under the acute effect of the drug. How to cite this article: Novoa, C., Solano, J. L., Ballesteros-Acosta, H., Lamprea, R. M., & Ortega, L. A. (2021). Nicotine Differentially Modulates Emotional-Locomotor Interactions for Adult or Adolescent Rats. Revista Colombiana de Psicología, 31(1), 13-22. https://doi.org/10.15446/rcp.v31n1.89822

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尼古丁对成年或青少年大鼠情绪运动相互作用的差异调节

先前的研究表明，尼古丁和其他滥用药物会刺激中脑边缘回路中的多巴胺能神经元。通过长期暴露于药物而持续激活该回路可促进运动敏化。然而，在不同发育阶段评估尼古丁诱导的运动敏化时，有不一致的报道。我们评估了开放性特定区域的探索性行为作为行为解除抑制的指标，以及一般运动活动作为尼古丁诱导的运动敏化的指标，以进一步探讨不同发育阶段动物对尼古丁暴露的行为适应机制。我们发现，虽然青春期大鼠和成年大鼠对尼古丁诱导的运动致敏反应相同，但尼古丁仅在青春期大鼠中破坏了对风险相关行为的抑制。总之，我们的研究结果表明，长期每日暴露于尼古丁可增强其对运动活动的刺激作用。在青少年中，这种效果伴随着药物急性作用下抑制风险相关行为的能力下降。本文出处:Novoa, C, Solano, J. L.， Ballesteros-Acosta, H.， Lamprea, R. M.， & Ortega, L. A.(2021)。尼古丁对成年或青春期大鼠情绪-运动相互作用的差异调节。哥伦比亚研究Psicología, 31(1)， 13-22。https://doi.org/10.15446/rcp.v31n1.89822

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来源期刊

Revista Colombiana de Psicologia Social Sciences-Social Sciences (miscellaneous)

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

52 weeks

期刊介绍： The Revista Colombiana de Psicología (RCP) aims to reach educational and cultural institutions interested in the psychological science, as well as psychologists and students of psychology or related disciplines. The goal of the journal is to increase public knowledge about psychology in Latin America by publishing original, peer-reviewed, articles within the several fields of psychology. In this way, RCP aims at creating a stronger academic community in this field in Latin America and to spread state-of-the-art research agendas at the international level. RCP publishes empirical and theoretical works that follow the guide lines accepted by the different scientific and theoretical perspectives in psychology, and presented as essays, meta-analysis, literature reviews and empirical studies.