{"title":"A novel idea of sulfamic acid as an efficient catalyst for the synthesis of 2-azapyrrolizidine derivatives","authors":"R. Tafer, R. Boulcina, A. Debache","doi":"10.2174/2213337209666220728114131","DOIUrl":null,"url":null,"abstract":"\n\nThe synthesis of 2-azapyrrolizidine scaffolds has fascinated scientists due to their potential biological activities.\n\n\n\nAn efficient and environmentally sustainable synthetic method has been presented to synthesize structurally various 2-azapyrrolizidines via three-component reaction.\n\n\n\nThe condensation of aldehydes, hydantoin, and malononitrile in the presence of green and sustainable sulfamic acid as catalyst in mild conditions has been achieved.\n\n\n\nThe present protocol leads in most cases to the desired products in high yields.\n\n\n\nThe synthetic efficiency and operational simplicity make the present procedure cost effective, time efficient and eco-friendly for the synthesis of substituted 2-azapyrrolizidines.\n","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":" ","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organocatalysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2213337209666220728114131","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The synthesis of 2-azapyrrolizidine scaffolds has fascinated scientists due to their potential biological activities.
An efficient and environmentally sustainable synthetic method has been presented to synthesize structurally various 2-azapyrrolizidines via three-component reaction.
The condensation of aldehydes, hydantoin, and malononitrile in the presence of green and sustainable sulfamic acid as catalyst in mild conditions has been achieved.
The present protocol leads in most cases to the desired products in high yields.
The synthetic efficiency and operational simplicity make the present procedure cost effective, time efficient and eco-friendly for the synthesis of substituted 2-azapyrrolizidines.
期刊介绍：
Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.
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