{"title":"INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges.","authors":"G. Jungersen, J. Piedrahita","doi":"10.1093/ilar/ilz014","DOIUrl":null,"url":null,"abstract":"Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune peculiarities, the selection and design of appropriate immune-relevant animal models is, however, not following a straightforward path. The topics in this issue of the ILAR Journal provide assessments of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs.","PeriodicalId":56299,"journal":{"name":"Ilar Journal","volume":"1 1","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/ilar/ilz014","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ilar Journal","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1093/ilar/ilz014","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune peculiarities, the selection and design of appropriate immune-relevant animal models is, however, not following a straightforward path. The topics in this issue of the ILAR Journal provide assessments of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs.
期刊介绍：
The ILAR Journal is the peer-reviewed, theme-oriented publication of the Institute for Laboratory Animal Research (ILAR), which provides timely information for all who study, use, care for, and oversee the use of animals in research. The journal publishes original articles that review research on animals either as direct subjects or as surrogates for humans. According to policy, any previously unpublished animal research reported in the ILAR Journal will have been conducted according to the scientific, technical, and humanely appropriate guidelines current at the time the research was conducted in accordance with the Guide for the Care and Use of Laboratory Animals or other guidance provided by taxonomically-oriented professional societies (e.g., American Society of Mammalogy) as referenced in the Guide.
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