Recent Progress on Urinary Exosomal miRNAs in Bladder Cancer

Abstract

Bladder cancer (Bca) is one of the most common tumors in the urinary system. Cystoscopy biopsy is a gold standard for diagnosis of Bca in the clinic. However, cystoscopy biopsy is invasive, costly and invasive process causing pain in the patients. Because the Bca cells are closely in contact with urine, and the exosomes of the Bca can pass through the base membrane and transport the microRNA (miRNAs) to the urine, so the detection of the exosome-derived miRNAs in the urine is expected to be a new non-invasive method for diagnostics of Bca. Recently, liquid biopsy for miRNAs in urine is the recent research hotspot. In this review, we mainly introduce the feasibility of the application of the miRNAs from exosome to Bca, and its feasibility to detect Bca.