IL-17A rs2275913 gene polymorphism in patients with diabetic nephropathy

IF 1.1 Q4 IMMUNOLOGY Immunopathologia Persa Pub Date : 2022-04-24 DOI:10.34172/ipp.2022.29320

Akbar Nazarian, S. M. Hejazian, E. Ahmadian, S. Zununi Vahed, M. Haghi, M. Mobasseri, M. Ardalan

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引用次数: 2

Abstract

Introduction: Diabetic nephropathy (DN) is a major microvascular complication of diabetes, leading to end-stage renal disease (ESRD). Objectives: The aim of this study was to investigate the association between the rs2275913 polymorphism of interleukin-17 (IL-17) gene and the incidence of kidney disease in patients with type 2 diabetes (T2D). Patients and Methods: Blood samples were collected from 113 T2D patients including 56 patients with nephropathy and 57 patients without nephropathy. In addition, 150 healthy individuals were included in this study to compare the results. Gene study was conducted by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. Results: The frequency of A allele of IL-17A (rs2275913) gene polymorphism was significantly higher in patients with DN compared to healthy controls (P=0.043). In addition, serum creatinine levels were significantly higher in DN patients regardless of their genotypes (P<0.001). Conclusion: Our results showed that diabetic patients who carry at least one A allele of IL-17A (rs2275913) gene polymorphism may develop DN.

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糖尿病肾病患者IL-17A rs2275913基因多态性的研究

导读:糖尿病肾病(DN)是糖尿病的主要微血管并发症，可导致终末期肾病(ESRD)。目的:本研究旨在探讨2型糖尿病(T2D)患者白细胞介素-17 (IL-17)基因rs2275913多态性与肾脏疾病发生率的关系。患者与方法:采集113例T2D患者血样，其中合并肾病患者56例，非肾病患者57例。此外，本研究还包括150名健康个体来比较结果。采用限制性片段长度多态性-聚合酶链反应(RFLP-PCR)方法进行基因研究。结果:DN患者IL-17A (rs2275913)基因多态性等位基因频率显著高于健康对照组(P=0.043)。此外，无论基因型如何，DN患者血清肌酐水平均显著升高(P<0.001)。结论:携带IL-17A (rs2275913)基因多态性至少一个A等位基因的糖尿病患者可能发生DN。

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