D. Moreno-Lorenzana, R. Juárez-Velázquez, D. Martínez-Anaya, Patricia Péez-Vera
{"title":"CRLF2 (Cytokine receptor like factor 2)","authors":"D. Moreno-Lorenzana, R. Juárez-Velázquez, D. Martínez-Anaya, Patricia Péez-Vera","doi":"10.4267/2042/70641","DOIUrl":null,"url":null,"abstract":"CRLF2 is a member of type I cytokine receptor family. CRLF2 forms a functional complex with IL7 receptor α chain and thymic stromal lymphopoietin, this complex induces the activation of signal transducers and activators of transcription proteins. The overexpression of CRLF2 induced by genetic rearrangements has been described in acute lymphoblastic leukemia.","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4267/2042/70641","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 3
Abstract
CRLF2 is a member of type I cytokine receptor family. CRLF2 forms a functional complex with IL7 receptor α chain and thymic stromal lymphopoietin, this complex induces the activation of signal transducers and activators of transcription proteins. The overexpression of CRLF2 induced by genetic rearrangements has been described in acute lymphoblastic leukemia.
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