Research progress in stimuli-responsive mesoporous silica nano drug delivery systems for tumor therapy

Chenlu Huang, Dunwan Zhu
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Abstract

In recent years, mesoporous silica nanoparticles (MSNs) have been widely used in the construction of various intelligent drug delivery systems due to their unique and excellent properties. The stimuli-responsive drug delivery system based on mesoporous silica nanoparticles can effectively load anticancer drugs and target them to tumor cells, and then responsively release anticancer drugs under the action of specific stimulation signals. The method of specifically delivering anticancer drugs to target sites not only can greatly improvethe drug efficacy, but also effectively reduce the side effects of anticancer drugs on normal tissues and organs. Thereby the advantages of anticancer drugs in tumor therapy are improved. In this paper, the applications and developments of stimuli-responsive mesoporous silica nano drug delivery systems in tumor therapy were summarized. Key words: Mesoporous silica nanoparticles; Stimuli-responsive; Controlled release; Tumor therapy
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用于肿瘤治疗的刺激响应性介孔二氧化硅纳米给药系统的研究进展
近年来,介孔二氧化硅纳米颗粒(MSNs)由于其独特而优异的性能被广泛应用于各种智能给药系统的构建中。基于介孔二氧化硅纳米颗粒的刺激反应性药物递送系统可以有效地装载抗癌药物并靶向肿瘤细胞,然后在特定刺激信号的作用下响应性释放抗癌药物。这种将抗癌药物特异性递送到靶点的方法不仅可以大大提高药物疗效,还可以有效地减少抗癌药物对正常组织和器官的副作用。从而提高了抗癌药物在肿瘤治疗中的优势。本文综述了刺激反应型介孔二氧化硅纳米给药系统在肿瘤治疗中的应用及进展。关键词:介孔二氧化硅纳米颗粒;Stimuli-responsive;控制释放;肿瘤治疗
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