Type I photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy

IF 9.1 Q1 ENGINEERING, CHEMICAL Green Chemical Engineering Pub Date : 2023-09-01 DOI:10.1016/j.gce.2022.07.004
Chao Pan, Weijun Zhao, Xiaolei Zhao, Zhenxing Liu, Xiangyu Li, Yanting Lyu, Xupeng Wu, Zhirong Zhu, Wei-Hong Zhu, Qi Wang
{"title":"Type I photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy","authors":"Chao Pan,&nbsp;Weijun Zhao,&nbsp;Xiaolei Zhao,&nbsp;Zhenxing Liu,&nbsp;Xiangyu Li,&nbsp;Yanting Lyu,&nbsp;Xupeng Wu,&nbsp;Zhirong Zhu,&nbsp;Wei-Hong Zhu,&nbsp;Qi Wang","doi":"10.1016/j.gce.2022.07.004","DOIUrl":null,"url":null,"abstract":"<div><p>Image guided photodynamic therapy (PDT) combines fluorescence tracing and phototherapy, which can achieve a more accurate and effective treatment effect. However, traditional photosensitizers are limited by the aggregation-caused fluorescence quenching (ACQ) effect and low reactive oxygen species (ROS) generation in a hypoxic environment, resulting in poor imaging and treatment effect. Herein, we report a tricyano-methylene-pyridine (TCM)-based Type I aggregation-induced emission (AIE) photosensitizer (TCM-MBP), the strong electron acceptance (D-A) effect extends the wavelength to near-infrared (NIR) region to reduce the autofluorescence interference, and oxygen atoms provide lone pair electrons to enhance the inter system crossing (ISC) rate, thereby promoting the generation of more triplet states to produce ROS. The AIE photosensitizer TCM-MBP exhibited low oxygen dependence, NIR emission, and higher ROS production compared to commercially available Ce 6 and RB. After encapsulation with DSPE-PEG<sub>2000</sub>, TCM-MBP nanoparticles (TCM-MBP NPs) could penetrate to visualize cells and efficiently kill cancer cells upon light irradiation. This study provides an oxygen-independent AIE photosensitizer, which has great potential to replace the commercial ACQ photosensitizers.</p></div>","PeriodicalId":66474,"journal":{"name":"Green Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":9.1000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Chemical Engineering","FirstCategoryId":"1089","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666952822000590","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 1

Abstract

Image guided photodynamic therapy (PDT) combines fluorescence tracing and phototherapy, which can achieve a more accurate and effective treatment effect. However, traditional photosensitizers are limited by the aggregation-caused fluorescence quenching (ACQ) effect and low reactive oxygen species (ROS) generation in a hypoxic environment, resulting in poor imaging and treatment effect. Herein, we report a tricyano-methylene-pyridine (TCM)-based Type I aggregation-induced emission (AIE) photosensitizer (TCM-MBP), the strong electron acceptance (D-A) effect extends the wavelength to near-infrared (NIR) region to reduce the autofluorescence interference, and oxygen atoms provide lone pair electrons to enhance the inter system crossing (ISC) rate, thereby promoting the generation of more triplet states to produce ROS. The AIE photosensitizer TCM-MBP exhibited low oxygen dependence, NIR emission, and higher ROS production compared to commercially available Ce 6 and RB. After encapsulation with DSPE-PEG2000, TCM-MBP nanoparticles (TCM-MBP NPs) could penetrate to visualize cells and efficiently kill cancer cells upon light irradiation. This study provides an oxygen-independent AIE photosensitizer, which has great potential to replace the commercial ACQ photosensitizers.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
基于AIE发色团三氰基亚甲基吡啶的I型光敏剂用于光动力治疗
图像引导光动力疗法(PDT)结合了荧光追踪和光疗,可以达到更准确有效的治疗效果。然而,传统的光敏剂在缺氧环境中受到聚集引起的荧光猝灭(ACQ)效应和低活性氧(ROS)产生的限制,导致成像和治疗效果不佳。在此,我们报道了一种基于三氰基亚甲基吡啶(TCM)的I型聚集诱导发射(AIE)光敏剂(TCM-MBP),强电子接受(D-a)效应将波长扩展到近红外(NIR)区域以减少自发荧光干扰,氧原子提供孤对电子以增强系统间交叉(ISC)速率,从而促进产生更多的三重态以产生ROS。与市售的Ce 6和RB相比,AIE光敏剂TCM-MBP表现出低的氧依赖性、NIR发射和更高的ROS产生。用DSPE-PEG2000包封后,TCM-MBP纳米颗粒(TCM-MBP-NP)可以穿透以观察细胞,并在光照射下有效杀死癌症细胞。本研究提供了一种不依赖氧气的AIE光敏剂,它有很大的潜力取代商业ACQ光敏剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Green Chemical Engineering
Green Chemical Engineering Process Chemistry and Technology, Catalysis, Filtration and Separation
CiteScore
11.60
自引率
0.00%
发文量
58
审稿时长
51 days
期刊最新文献
OFC: Outside Front Cover Outside Back Cover Outside Back Cover OFC: Outside Front Cover Integration of physical information and reaction mechanism data for surrogate prediction model and multi-objective optimization of glycolic acid production
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1