PULMONARY ARTERY INFLAMMATION IN NON-SPECIFIC AORTOARTERITIS. Review

H.V. Mostbauer, M. Dzhus
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Abstract

Relevance. Nonspecific aortoarteritis (NAA) or Takayasu's disease can exacerbate life-threatening arteritis of the pulmonary artery (LA), which is usually diagnosed with delay and lead to a poor prognosis. Objective: to review the literature data on LA lesions in NAA to improve the diagnosis and timely appointment of appropriate treatment for better the prognosis of the overall outcome. Methods. Review of scientific literature in international electronic databases PubMed, Google Scholar by keywords for the period 2007-2022. The search was conducted by two independent authors. 90 sources were selected for analysis, of which 43 were used, which were written in English and met the search criteria. Results. In NAA, LA lesions are not a rare pathology, which is observed in 5.7-66% of cases. LA arteritis can manifest itself in the form of stenosis, occlusion, dilatation, aneurysm, thrombosis in situ, and thickening of the arteries. When LA is involved in the pathological process, the risk of developing pulmonary hypertension (LH), heart failure, and lung parenchymal lesions increases, which worsens the prognosis of such patients. The pathology of LA is often diagnosed with a delay due to nonspecific symptoms. It should be noted that in NAA LH can develop not only due to LA arteritis but also due to the presence of pathology in the left heart. Conclusions. LA lesions are common in patients with NAA, however, are often diagnosed with a delay. Involvement of LA in the pathological process can lead to the development of LH, HF, and lung parenchymal lesions and worsen the prognosis, so early diagnosis and timely appropriate treatment are important to reduce morbidity and mortality due to LA lesions in NAA. In addition, pulmonary blood flow and intracardiac hemodynamics should be monitored regularly.
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非特异性大动脉炎中的肺动脉炎症。审查
的相关性。非特异性主动脉炎(NAA)或Takayasu病可加重危及生命的肺动脉动脉炎(LA),其诊断通常延迟并导致预后不良。目的:回顾NAA中LA病变的文献资料,以提高对LA病变的诊断和及时选择合适的治疗方法,改善预后。方法。国际电子数据库PubMed, b谷歌Scholar中2007-2022年的科学文献综述。这项研究是由两位独立作者进行的。选取90篇文献进行分析,其中使用了43篇,均为英文,符合检索标准。结果。在NAA中,LA病变并不罕见,其发生率为5.7% -66%。LA动脉炎可表现为狭窄、闭塞、扩张、动脉瘤、原位血栓形成和动脉增厚。当LA参与病理过程时,发生肺动脉高压(LH)、心力衰竭、肺实质病变的风险增加,使患者预后恶化。由于非特异性症状,LA的病理诊断往往延迟。值得注意的是,在NAA中,LH不仅可以由于左动脉炎而发展,也可以由于左心病理的存在而发展。结论。LA病变在NAA患者中很常见,但通常诊断延迟。LA参与病理过程可导致LH、HF及肺实质病变的发生,使预后恶化,因此早期诊断和及时适当治疗对于降低NAA LA病变的发病率和死亡率具有重要意义。此外,应定期监测肺血流和心内血流动力学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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审稿时长
7 weeks
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