Relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features

Q4 Nursing 中华临床营养杂志 Pub Date : 2019-06-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2019.03.003

Jiapei Li, Weigang Zhao, Yong Fu, Ying-yue Dong, Juan Li

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Abstract

Objective To explore the relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features. Methods 50 patients with gestational hyperglycemia, diagnosed by 100 g oral glucose tolerance test(OGTT) during mid-trimester were selected between 2009 and 2012. 50 pregnant women with normal glucose tolerance of matched age and body mass index were included in the control group. The blood samples during mid-trimester and the clinical parameters were collected. MTNR1B DNA methylation levels were measured. Results After adjusting age and body mass index, the CpG locus located at + 64 bp away from the translation initiation site of MTNR1B was related with gestational diabetes (OR=0.859, 95% CI: 0.772-0.955, P=0.005). DNA methylation level of several MTNR1B loci was also related with gestational glucose and lipid metabolism features. Conclusion MTNR1B DNA methylation is related with gestational diabetes and gestational glucose and lipid metabolism. Key words: MTNR1B DNA methylation; Gestational diabetes mellitus; Gestational glucose and lipid metabolism

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MTNR1B DNA甲基化与妊娠期糖尿病及妊娠期糖脂代谢特征的关系

目的探讨MTNR1B DNA甲基化与妊娠期糖尿病及妊娠期糖脂代谢特征的关系。方法选择2009 ~ 2012年中期经100g口服葡萄糖耐量试验(OGTT)诊断为妊娠高血糖的患者50例。50例糖耐量正常、年龄、体重指数相匹配的孕妇作为对照组。采集妊娠中期血液样本及临床参数。检测MTNR1B DNA甲基化水平。结果在调整年龄和体重指数后，位于MTNR1B翻译起始位点+ 64 bp的CpG位点与妊娠糖尿病相关(OR=0.859, 95% CI: 0.772 ~ 0.955, P=0.005)。几个MTNR1B位点的DNA甲基化水平也与妊娠期糖脂代谢特征有关。结论MTNR1B DNA甲基化与妊娠期糖尿病及糖脂代谢有关。关键词:MTNR1B DNA甲基化;妊娠期糖尿病;妊娠期糖脂代谢

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.