{"title":"Optimal control analysis of combined chemotherapy-immunotherapy treatment regimens in a PKPD cancer evolution model","authors":"Anuraag Bukkuri","doi":"10.11145/j.biomath.2020.02.137","DOIUrl":null,"url":null,"abstract":"The author constructs a mathematical model capturing tumor-immune dynamics, incorporating the evolution of drug resistance, pharmacokinetics and pharmacodynamics of administered drugs, and immunotherapy possibilities. Numerical simulations are performed to analyze the model under a variety of treatment possibilities. A sensitivity analysis is performed to determine the parameters contributing the most to the variance in effector cell, resistant, and sensitive tumor cell populations. Then, a detailed optimal control analysis is performed, along with a numerical simulation of optimal treatment profiles for a hypothetical patient.","PeriodicalId":52247,"journal":{"name":"Biomath","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomath","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11145/j.biomath.2020.02.137","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 10
Abstract
The author constructs a mathematical model capturing tumor-immune dynamics, incorporating the evolution of drug resistance, pharmacokinetics and pharmacodynamics of administered drugs, and immunotherapy possibilities. Numerical simulations are performed to analyze the model under a variety of treatment possibilities. A sensitivity analysis is performed to determine the parameters contributing the most to the variance in effector cell, resistant, and sensitive tumor cell populations. Then, a detailed optimal control analysis is performed, along with a numerical simulation of optimal treatment profiles for a hypothetical patient.
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