Exploring Ribosome Code: Unveiling A Novel Dimension of Gene Regulation in Carcinogenesis

Abstract

The central dogma of molecular biology has traditionally viewed ribosomes as uniform entities translating mRNA into proteins with mechanical precision. Recent findings challenge this perspective, revealing unexpected ribosome heterogeneity within cells, thus proposing a novel mechanism for diversifying protein synthesis. This concept parallels the “histone code” hypothesis, leading to the proposition of a “ribosome code” that suggests variations in ribosomal protein stoichiometry, paralogs, and modifications may preferentially translate certain mRNA populations. The role of ribosome heterogeneity in cancer pathogenesis, however, remains a subject of debate. Evidence suggests that alterations in ribosome composition, structure, and activity could influence abnormal protein synthesis, thus contributing to tumorigenesis. This is supported by the correlation between enhanced ribosome biogenesis, protein synthesis, and tumor growth, as well as the observed modifications in cancer ribosomes. Examining the nuances of ribosome heterogeneity, its influence on translational biases, and implications for tumor biology could significantly deepen our understanding of cancer’s molecular landscape, potentially unveiling novel therapeutic targets.