{"title":"Feasibility study of positronium application for blood clots structural characteristics","authors":"S. Moyo, P. Moskal, E. Stępień","doi":"10.2478/bioal-2022-0087","DOIUrl":null,"url":null,"abstract":"\n Positron-electron annihilation in living organisms occurs in about 30% via the formation of a metastable ortho-positronium atom that annihilates into two 511 keV photons in tissues because of the pick-off and conversion processes. Positronium (Ps) annihilation lifetime and intensities can be used to determine the size and quantity of defects in a material’s microstructure, such as voids or pores in the range of nanometers. This is particularly true for blood clots. Here we present pilot investigations of positronium properties in fibrin clots. The studies are complemented by the use of SEM Edax and micro-computed tomography (µCT) to evaluate the extracted thrombotic material’s properties. µCT is a versatile characterization method offering in situ and in operando possibilities and is a qualitative diagnostic tool. With µCT the presence of pores, cracks, and structural errors can be verified, and hence the 3D inner structure of samples can be investigated.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bio-Algorithms and Med-Systems","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/bioal-2022-0087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 1
Abstract
Positron-electron annihilation in living organisms occurs in about 30% via the formation of a metastable ortho-positronium atom that annihilates into two 511 keV photons in tissues because of the pick-off and conversion processes. Positronium (Ps) annihilation lifetime and intensities can be used to determine the size and quantity of defects in a material’s microstructure, such as voids or pores in the range of nanometers. This is particularly true for blood clots. Here we present pilot investigations of positronium properties in fibrin clots. The studies are complemented by the use of SEM Edax and micro-computed tomography (µCT) to evaluate the extracted thrombotic material’s properties. µCT is a versatile characterization method offering in situ and in operando possibilities and is a qualitative diagnostic tool. With µCT the presence of pores, cracks, and structural errors can be verified, and hence the 3D inner structure of samples can be investigated.
期刊介绍：
The journal Bio-Algorithms and Med-Systems (BAMS), edited by the Jagiellonian University Medical College, provides a forum for the exchange of information in the interdisciplinary fields of computational methods applied in medicine, presenting new algorithms and databases that allows the progress in collaborations between medicine, informatics, physics, and biochemistry. Projects linking specialists representing these disciplines are welcome to be published in this Journal. Articles in BAMS are published in English. Topics Bioinformatics Systems biology Telemedicine E-Learning in Medicine Patient''s electronic record Image processing Medical databases.
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