Pub Date : 2023-04-20DOI: 10.48550/arXiv.2304.10675
Richard Mayne, Nic Roberts, Neil Phillips, Roshan Weerasekera, A. Adamatzky
Living fungal mycelium networks are proven to have properties of memristors, capacitors and various sensors. To further progress our designs in fungal electronics we need to evaluate how electrical signals can be propagated through mycelium networks. We investigate the ability of mycelium-bound composites to convey electrical signals, thereby enabling the transmission of frequency-modulated information through mycelium networks. Mycelia were found to reliably transfer signals with a recoverable frequency comparable to the input, in the 100Hz to 10 000Hz frequency range. Mycelial adaptive responses, such as tissue repair, may result in fragile connections, however. While the mean amplitude of output signals was not reproducible among replicate experiments exposed to the same input frequency, the variance across groups was highly consistent. Our work is supported by NARX modelling through which an approximate transfer function was derived. These findings advance the state of the art of using mycelium-bound composites in analogue electronics and unconventional computing.
{"title":"Propagation of electrical signals by fungi","authors":"Richard Mayne, Nic Roberts, Neil Phillips, Roshan Weerasekera, A. Adamatzky","doi":"10.48550/arXiv.2304.10675","DOIUrl":"https://doi.org/10.48550/arXiv.2304.10675","url":null,"abstract":"Living fungal mycelium networks are proven to have properties of memristors, capacitors and various sensors. To further progress our designs in fungal electronics we need to evaluate how electrical signals can be propagated through mycelium networks. We investigate the ability of mycelium-bound composites to convey electrical signals, thereby enabling the transmission of frequency-modulated information through mycelium networks. Mycelia were found to reliably transfer signals with a recoverable frequency comparable to the input, in the 100Hz to 10 000Hz frequency range. Mycelial adaptive responses, such as tissue repair, may result in fragile connections, however. While the mean amplitude of output signals was not reproducible among replicate experiments exposed to the same input frequency, the variance across groups was highly consistent. Our work is supported by NARX modelling through which an approximate transfer function was derived. These findings advance the state of the art of using mycelium-bound composites in analogue electronics and unconventional computing.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":"30 1","pages":"104933"},"PeriodicalIF":1.2,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77626323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.48550/arXiv.2303.17563
Panagiotis Mougkogiannis, A. Adamatzky
Proteinoids, or thermal proteins, are produced by heating amino acids to their melting point and initiating polymerisation to produce polymeric chains. In aqueous solutions proteinoids swell into hollow microspheres. These microspheres produce endogenous burst of electrical potential spikes and change patterns of their electrical activity in response to illumination. We report results on a detailed investigation on the effects of white cold light on the spiking of proteinoids. We study how different types and intensities of light determine proteinoids' spiking amplitude, period, and pattern. The results of this study will be utilised to evaluate proteinoids for their potential as optical sensors and their application in unconventional computing.
{"title":"Light induced spiking of proteinoids","authors":"Panagiotis Mougkogiannis, A. Adamatzky","doi":"10.48550/arXiv.2303.17563","DOIUrl":"https://doi.org/10.48550/arXiv.2303.17563","url":null,"abstract":"Proteinoids, or thermal proteins, are produced by heating amino acids to their melting point and initiating polymerisation to produce polymeric chains. In aqueous solutions proteinoids swell into hollow microspheres. These microspheres produce endogenous burst of electrical potential spikes and change patterns of their electrical activity in response to illumination. We report results on a detailed investigation on the effects of white cold light on the spiking of proteinoids. We study how different types and intensities of light determine proteinoids' spiking amplitude, period, and pattern. The results of this study will be utilised to evaluate proteinoids for their potential as optical sensors and their application in unconventional computing.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":"1 1","pages":"105015"},"PeriodicalIF":1.2,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91128500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-09DOI: 10.48550/arXiv.2302.05255
Panagiotis Mougkogiannis, Neil Phillips, A. Adamatzky
Proteinoids, or thermal proteins, are inorganic entities formed by heating amino acids to their melting point and commencing polymerisation to form polymeric chains. Typically, their diameters range from 1μm to 10μm. Some amino acids incorporated into proteinoid chains are more hydrophobic than others, leading proteinoids to cluster together when they are present in aqueous solutions at specific concentrations, allowing them to grow into microspheres. The peculiar structure of proteinoids composed of linked amino acids endows them with unique properties, including action-potential like spiking of electrical potential. These unique properties make ensembles of proteinoid microspheres a promising substrate for designing future artificial brains and unconventional computing devices. To evaluate a potential of proteinoid microspheres for unconventional electronic devices we measure and analyse the data-transfer capacities of proteinoid microspheres. In experimental laboratory conditions we demonstrate that the transfer function of proteinoids microspheres is a nontrivial phenomenon, which might be due to the wide range of proteinoid shapes, sizes, and structures.
{"title":"Transfer Functions of Proteinoid Microspheres","authors":"Panagiotis Mougkogiannis, Neil Phillips, A. Adamatzky","doi":"10.48550/arXiv.2302.05255","DOIUrl":"https://doi.org/10.48550/arXiv.2302.05255","url":null,"abstract":"Proteinoids, or thermal proteins, are inorganic entities formed by heating amino acids to their melting point and commencing polymerisation to form polymeric chains. Typically, their diameters range from 1μm to 10μm. Some amino acids incorporated into proteinoid chains are more hydrophobic than others, leading proteinoids to cluster together when they are present in aqueous solutions at specific concentrations, allowing them to grow into microspheres. The peculiar structure of proteinoids composed of linked amino acids endows them with unique properties, including action-potential like spiking of electrical potential. These unique properties make ensembles of proteinoid microspheres a promising substrate for designing future artificial brains and unconventional computing devices. To evaluate a potential of proteinoid microspheres for unconventional electronic devices we measure and analyse the data-transfer capacities of proteinoid microspheres. In experimental laboratory conditions we demonstrate that the transfer function of proteinoids microspheres is a nontrivial phenomenon, which might be due to the wide range of proteinoid shapes, sizes, and structures.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":"1 1","pages":"104892"},"PeriodicalIF":1.2,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83377819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The intrinsic resolution of Positron Emission Tomography (PET) imaging is bound by positron range effects, wherein the radioactive decay of the imaging tracer occurs at a disjoint location from positron annihilation. Compounding this issue are the variable ranges positrons achieve, depending on tracer species (the energy they are emitted with) and the medium they travel in (bone vs soft tissue, for example) - causing the range to span more than an order of magnitude across various study scenarios (~0.19 mm to ~6.4 mm). Radioisotopes, such as Zr-89, exhibit dual emissions of positron and prompt gammas, offering an opportunity for accurate tracer positioning as prompt gammas originate from the tracer location. These multi-emission radiotracers have historically suffered from increased noise corresponding to the third gamma interfering in annihilation gamma coincidence pairing. Recent advancements, however, have brought to light the unique property of annihilation gammas having scattering kinematics distinct from random gamma pairs. These properties are born from the singular quantum entanglement state available to the gamma pair following para-positronium decay which prescribes linearly orthogonal polarization. Such coherent polarization is not shared by prompt gamma emissions, offering an opportunity for their discrimination. We present an investigation into this technique, comparing the distribution of relevant scattering kinematics of entangled annihilation gammas and corresponding prompt gammas via a Monte Carlo simulation.
{"title":"Application of quantum entanglement induced polarization for dual-positron and prompt gamma imaging.","authors":"Gregory Romanchek, Greyson Shoop, Shiva Abbaszadeh","doi":"10.5604/01.3001.0054.1817","DOIUrl":"10.5604/01.3001.0054.1817","url":null,"abstract":"<p><p>The intrinsic resolution of Positron Emission Tomography (PET) imaging is bound by positron range effects, wherein the radioactive decay of the imaging tracer occurs at a disjoint location from positron annihilation. Compounding this issue are the variable ranges positrons achieve, depending on tracer species (the energy they are emitted with) and the medium they travel in (bone vs soft tissue, for example) - causing the range to span more than an order of magnitude across various study scenarios (~0.19 mm to ~6.4 mm). Radioisotopes, such as Zr-89, exhibit dual emissions of positron and prompt gammas, offering an opportunity for accurate tracer positioning as prompt gammas originate from the tracer location. These multi-emission radiotracers have historically suffered from increased noise corresponding to the third gamma interfering in annihilation gamma coincidence pairing. Recent advancements, however, have brought to light the unique property of annihilation gammas having scattering kinematics distinct from random gamma pairs. These properties are born from the singular quantum entanglement state available to the gamma pair following para-positronium decay which prescribes linearly orthogonal polarization. Such coherent polarization is not shared by prompt gamma emissions, offering an opportunity for their discrimination. We present an investigation into this technique, comparing the distribution of relevant scattering kinematics of entangled annihilation gammas and corresponding prompt gammas via a Monte Carlo simulation.</p>","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":"19 1","pages":"9-16"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Positron-electron annihilation in living organisms occurs in about 30% via the formation of a metastable ortho-positronium atom that annihilates into two 511 keV photons in tissues because of the pick-off and conversion processes. Positronium (Ps) annihilation lifetime and intensities can be used to determine the size and quantity of defects in a material’s microstructure, such as voids or pores in the range of nanometers. This is particularly true for blood clots. Here we present pilot investigations of positronium properties in fibrin clots. The studies are complemented by the use of SEM Edax and micro-computed tomography (µCT) to evaluate the extracted thrombotic material’s properties. µCT is a versatile characterization method offering in situ and in operando possibilities and is a qualitative diagnostic tool. With µCT the presence of pores, cracks, and structural errors can be verified, and hence the 3D inner structure of samples can be investigated.
{"title":"Feasibility study of positronium application for blood clots structural characteristics","authors":"S. Moyo, P. Moskal, E. Stępień","doi":"10.2478/bioal-2022-0087","DOIUrl":"https://doi.org/10.2478/bioal-2022-0087","url":null,"abstract":"\u0000 Positron-electron annihilation in living organisms occurs in about 30% via the formation of a metastable ortho-positronium atom that annihilates into two 511 keV photons in tissues because of the pick-off and conversion processes. Positronium (Ps) annihilation lifetime and intensities can be used to determine the size and quantity of defects in a material’s microstructure, such as voids or pores in the range of nanometers. This is particularly true for blood clots. Here we present pilot investigations of positronium properties in fibrin clots. The studies are complemented by the use of SEM Edax and micro-computed tomography (µCT) to evaluate the extracted thrombotic material’s properties. µCT is a versatile characterization method offering in situ and in operando possibilities and is a qualitative diagnostic tool. With µCT the presence of pores, cracks, and structural errors can be verified, and hence the 3D inner structure of samples can be investigated.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46501488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Multi-molecule imaging and inter-molecular imaging are not fully implemented yet, however, can become an alternative in nuclear medicine. In this review article, we present arguments demonstrating that the advent of the Compton positron emission tomography (Compton-PET) system and the invention of the quantum chemical sensing method with double photon emission imaging (DPEI) provide realistic perspectives for visualizing inter-molecular and multi-molecule in nuclear medicine with MeV photon. In particular, the pH change of InCl3 solutions can be detected and visualized in a three-dimensional image by combining the hyperfine electric quadrupole interaction sensing and DPEI. Moreover, chemical states, such as chelating, can be detected through angular correlation sensing. We argue that multi-molecule and chemical sensing could be a realistic stream of research in future nuclear medicine.
{"title":"Multi-molecule imaging and inter-molecular imaging in nuclear medicine","authors":"K. Shimazoe, M. Uenomachi","doi":"10.2478/bioal-2022-0081","DOIUrl":"https://doi.org/10.2478/bioal-2022-0081","url":null,"abstract":"\u0000 Multi-molecule imaging and inter-molecular imaging are not fully implemented yet, however, can become an alternative in nuclear medicine. In this review article, we present arguments demonstrating that the advent of the Compton positron emission tomography (Compton-PET) system and the invention of the quantum chemical sensing method with double photon emission imaging (DPEI) provide realistic perspectives for visualizing inter-molecular and multi-molecule in nuclear medicine with MeV photon. In particular, the pH change of InCl3 solutions can be detected and visualized in a three-dimensional image by combining the hyperfine electric quadrupole interaction sensing and DPEI. Moreover, chemical states, such as chelating, can be detected through angular correlation sensing. We argue that multi-molecule and chemical sensing could be a realistic stream of research in future nuclear medicine.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44925266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Gonzalez-Montoro, J. Barberá, D. Sanchez, Alvaro Mondejar, M. Freire, Karel Diaz, Alejandro Lucero, S. Jiménez-Serrano, J. Alamo, C. Morera-Ballester, J. Barrio, N. Cucarella, V. Ilisie, L. Moliner, C. Valladares, Antonio J. Gonzalez, John O. Prior, J. Benlloch
In this article, we present the geometrical design and preliminary results of a high sensitivity organ-specific Positron Emission Tomography (PET) system dedicated to the study of the human brain. The system, called 4D-PET, will allow accurate imaging of brain studies due to its expected high sensitivity, high 3D spatial resolution and, by including precise photon time of flight (TOF) information, a boosted signal-to-noise ratio (SNR). The 4D-PET system incorporates an innovative detector design based on crystal slabs (semi-monolithic) that enables accurate 3D photon impact positioning (including photon Depth of Interaction (DOI) measurement), while providing a precise determination of the photon arrival time to the detector. The detector includes a novel readout system that reduces the number of detector signals in a ratio of 4:1 thus, alleviating complexity and cost. The analog output signals are fed to the TOFPET2 ASIC (PETsys) for scalability purposes. The present manuscript reports the evaluation of the 4D-PET detector, achieving best values 3D resolution values of <1.6 mm (pixelated axis), 2.7±0.5 mm (monolithic axis) and 3.4±1.1 (DOI axis) mm; 359 ± 7 ps coincidence time resolution (CTR); 10.2±1.5 % energy resolution; and sensitivity of 16.2% at the center of the scanner (simulated). Moreover, a comprehensive description of the 4D-PET architecture (that includes 320 detectors), some pictures of its mechanical assembly, and simulations on the expected image quality are provided.
{"title":"A new brain dedicated PET scanner with 4D detector information","authors":"A. Gonzalez-Montoro, J. Barberá, D. Sanchez, Alvaro Mondejar, M. Freire, Karel Diaz, Alejandro Lucero, S. Jiménez-Serrano, J. Alamo, C. Morera-Ballester, J. Barrio, N. Cucarella, V. Ilisie, L. Moliner, C. Valladares, Antonio J. Gonzalez, John O. Prior, J. Benlloch","doi":"10.2478/bioal-2022-0083","DOIUrl":"https://doi.org/10.2478/bioal-2022-0083","url":null,"abstract":"\u0000 In this article, we present the geometrical design and preliminary results of a high sensitivity organ-specific Positron Emission Tomography (PET) system dedicated to the study of the human brain. The system, called 4D-PET, will allow accurate imaging of brain studies due to its expected high sensitivity, high 3D spatial resolution and, by including precise photon time of flight (TOF) information, a boosted signal-to-noise ratio (SNR).\u0000 The 4D-PET system incorporates an innovative detector design based on crystal slabs (semi-monolithic) that enables accurate 3D photon impact positioning (including photon Depth of Interaction (DOI) measurement), while providing a precise determination of the photon arrival time to the detector. The detector includes a novel readout system that reduces the number of detector signals in a ratio of 4:1 thus, alleviating complexity and cost. The analog output signals are fed to the TOFPET2 ASIC (PETsys) for scalability purposes.\u0000 The present manuscript reports the evaluation of the 4D-PET detector, achieving best values 3D resolution values of <1.6 mm (pixelated axis), 2.7±0.5 mm (monolithic axis) and 3.4±1.1 (DOI axis) mm; 359 ± 7 ps coincidence time resolution (CTR); 10.2±1.5 % energy resolution; and sensitivity of 16.2% at the center of the scanner (simulated). Moreover, a comprehensive description of the 4D-PET architecture (that includes 320 detectors), some pictures of its mechanical assembly, and simulations on the expected image quality are provided.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48429535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Durak-Kozica, Andrzej Wróbel, M. Platt, E. Stępień
Objectives: Extracellular vesicles (EVs) are heterogeneous membrane vesicles in diameter of 30-5000 nm, that transport proteins, non-coding RNAs (miRNAs), lipids and metabolites. Major populations include exosomes, ectosomes and apoptotic bodies. The purpose of this study was to compare the distribution of EVs obtained under different conditions of differential centrifugation, including ultracentrifugation, with the results developed based on a theoretical model. Methods: Immortalized endothelial cell line that expresses h-TERT (human telomerase) was used to release of EVs: microvascular TIME. EVs were isolated from the culture medium at different centrifugation parameters. The size distribution of the EVs was measured using TRPS technology on a qNano instrument.
{"title":"Comparison of qNANO results from the isolation of extracellular microvesicles with the theoretical model","authors":"M. Durak-Kozica, Andrzej Wróbel, M. Platt, E. Stępień","doi":"10.2478/bioal-2022-0088","DOIUrl":"https://doi.org/10.2478/bioal-2022-0088","url":null,"abstract":"\u0000 Objectives: Extracellular vesicles (EVs) are heterogeneous membrane vesicles in diameter of 30-5000 nm, that transport proteins, non-coding RNAs (miRNAs), lipids and metabolites. Major populations include exosomes, ectosomes and apoptotic bodies. The purpose of this study was to compare the distribution of EVs obtained under different conditions of differential centrifugation, including ultracentrifugation, with the results developed based on a theoretical model. Methods: Immortalized endothelial cell line that expresses h-TERT (human telomerase) was used to release of EVs: microvascular TIME. EVs were isolated from the culture medium at different centrifugation parameters. The size distribution of the EVs was measured using TRPS technology on a qNano instrument.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42036904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cascade nuclides emit two or more gamma rays successively through an intermediate state. The coincidence detection of cascade gamma rays provides several advantages in gamma-ray imaging. In this review article, three applications of the double photon coincidence method are reviewed. Double-photon emission imaging with mechanical collimators and Compton double-photon emission imaging can identify radioactive source positions with their angular-resolving detectors, and reduce the crosstalk between nuclides. In addition, a novel method of coincidence Compton imaging is proposed by taking coincidence detection between a Compton event and a photopeak events. Although this type of coincidence Compton imaging cannot specify the location, it can be useful in multi-nuclide Compton imaging.
{"title":"A double photon coincidence detection method for medical gamma-ray imaging","authors":"M. Uenomachi, K. Shimazoe, H. Takahashi","doi":"10.2478/bioal-2022-0080","DOIUrl":"https://doi.org/10.2478/bioal-2022-0080","url":null,"abstract":"\u0000 Cascade nuclides emit two or more gamma rays successively through an intermediate state. The coincidence detection of cascade gamma rays provides several advantages in gamma-ray imaging. In this review article, three applications of the double photon coincidence method are reviewed. Double-photon emission imaging with mechanical collimators and Compton double-photon emission imaging can identify radioactive source positions with their angular-resolving detectors, and reduce the crosstalk between nuclides. In addition, a novel method of coincidence Compton imaging is proposed by taking coincidence detection between a Compton event and a photopeak events. Although this type of coincidence Compton imaging cannot specify the location, it can be useful in multi-nuclide Compton imaging.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46914424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We develop a positronium imaging method for the Jagiellonian PET (J-PET) scanners based on the time-of-flight maximum likelihood expectation maximisation (TOF MLEM). The system matrix elements are calculated on-the-fly for the coincidences comprising two annihilation and one de-excitation photons that originate from the ortho-positronium (o-Ps) decay. Using the Geant4 library, a Monte Carlo simulation was conducted for four cylindrical 22Na sources of β+ decay with diverse o-Ps mean lifetimes, placed symmetrically inside the two JPET prototypes. The estimated time differences between the annihilation and the positron emission were aggregated into histograms (one per voxel), updated by the weights of the activities reconstructed by TOF MLEM. The simulations were restricted to include only the o-Ps decays into back-to-back photons, allowing a linear fitting model to be employed for the estimation of the mean lifetime from each histogram built in the log scale. To suppress the noise, the exclusion of voxels with activity below 2% – 10% of the peak was studied. The estimated o-Ps mean lifetimes were consistent with the simulation and distributed quasi -uniformly at high MLEM iterations. The proposed positronium imaging technique can be further upgraded to include various correction factors, as well as be modified according to realistic o-Ps decay models.
{"title":"Multi-photon time-of-flight MLEM application for the positronium imaging in J-PET","authors":"R. Shopa, K. Dulski","doi":"10.2478/bioal-2022-0082","DOIUrl":"https://doi.org/10.2478/bioal-2022-0082","url":null,"abstract":"\u0000 We develop a positronium imaging method for the Jagiellonian PET (J-PET) scanners based on the time-of-flight maximum likelihood expectation maximisation (TOF MLEM). The system matrix elements are calculated on-the-fly for the coincidences comprising two annihilation and one de-excitation photons that originate from the ortho-positronium (o-Ps) decay. Using the Geant4 library, a Monte Carlo simulation was conducted for four cylindrical 22Na sources of β+ decay with diverse o-Ps mean lifetimes, placed symmetrically inside the two JPET prototypes. The estimated time differences between the annihilation and the positron emission were aggregated into histograms (one per voxel), updated by the weights of the activities reconstructed by TOF MLEM. The simulations were restricted to include only the o-Ps decays into back-to-back photons, allowing a linear fitting model to be employed for the estimation of the mean lifetime from each histogram built in the log scale. To suppress the noise, the exclusion of voxels with activity below 2% – 10% of the peak was studied. The estimated o-Ps mean lifetimes were consistent with the simulation and distributed quasi -uniformly at high MLEM iterations. The proposed positronium imaging technique can be further upgraded to include various correction factors, as well as be modified according to realistic o-Ps decay models.","PeriodicalId":42620,"journal":{"name":"Bio-Algorithms and Med-Systems","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46202212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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