Preparation and in vitro evaluation of chitosan-based films for the sustained delivery of enrofloxacin

Q4 Veterinary Iranian Journal of Veterinary Science and Technology Pub Date : 2018-10-01 DOI:10.22067/VETERINARY.V10I1.70288

A. Rassouli, S. K. Falahatipour, Y. H. Ardakani, H. A. Javar, Katayoun Kiani, T. Z. Salehi

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Abstract

The implantable drug products are developed mainly to sustain the drug release. This study was conducted to formulate and evaluate cross-linked films of chitosan/β-glycerophosphate (β-GP) for the sustained delivery of enrofloxacin (ENR). Two types of formulations, single-layer (F1 and F2) and triple-layer (F3 and F4) films, were prepared. In vitro drug release, kinetic modelling, Fourier transform infrared spectroscopy (FTIR) spectra, morphological and microbiological studies were performed. Drug release from F1 and F2 continued up to 5 hours but from F3 and F4, it was extended over 96 and 168 hours, respectively. The cumulative drug release for F1, F2, F3 and F4 were 72.6, 70.1, 90.5 and 82.4%, respectively. The inhibition zones of bacterial growth by using positive controls and single layer films were significantly greater than those of triple-layer films (p < 0.05), indicating sustained drug release pattern of the multi-layer films. These findings suggest that the triple-layer chitosan/β-GP films could be effective to deliver ENR for a long period.

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壳聚糖基恩诺沙星持续给药膜的制备及体外评价

植入式药物产品的开发主要是为了维持药物的释放。本研究旨在制备和评价壳聚糖/β-甘油磷酸（β-GP）交联膜用于恩诺沙星（ENR）的持续递送。制备了两种类型的制剂，单层（F1和F2）和三层（F3和F4）膜。进行了体外药物释放、动力学建模、傅立叶变换红外光谱、形态学和微生物学研究。F1和F2的药物释放持续达5小时，但F3和F4的药物释放分别延长了96和168小时。F1、F2、F3和F4的累积药物释放率分别为72.6%、70.1%、90.5%和82.4%。使用阳性对照和单层膜对细菌生长的抑制区显著大于三层膜（p<0.05），表明多层膜具有持续的药物释放模式。这些发现表明，三层壳聚糖/β-GP膜可以长期有效地递送ENR。

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