Facile microfluidic device for droplets emulsion from small samples

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Flow Chemistry Pub Date : 2022-11-16 DOI:10.1007/s41981-022-00229-x

Dongliang He, Zerui Wu, Yao Lin, Guoyuan Li, Zhanhao Zhang, Yuheng Qiu, Yanan Ma, Chengqi Jia, Shan Wei, Guangzhu Shang, Xingyue Lei, Peng Hu, Liqun He

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Abstract

We presented a microfluidic device for the preparation of monodisperse microdroplets with a small volume of samples or reagents, which is power-free, user-friendly and based only on a highly portable syringe. Our method requires only hand-operated syringes and sharpened capillaries without any complicated experimental setups, making the entire system portable and user-friendly for non-technical users. Vacuum is generated by pulling the plunger of the syringe on site, and fluid is generated by vacuum. The droplet size can be flexibly controlled by adjusting the size of micropores and capillary or vacuum degree. More potentially, microliter samples or reagents can also be prepared from it into emulsions. Unlike traditional methods, our device is self-activated, avoiding the need for external power supply while ensuring fewer samples or reagents consumption, simplifying operations and saving costs, facilitating immediate diagnostic testing or field trace substance detection.

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简易微流体装置，用于小样品的液滴乳化

我们提出了一种微流体装置，用于用小体积的样品或试剂制备单分散微滴，该装置无需电源，用户友好且仅基于高度便携式注射器。我们的方法只需要手动注射器和锐化的毛细血管，不需要任何复杂的实验设置，使得整个系统便于携带，对非技术用户也很友好。在现场拉动注射器的柱塞产生真空，通过真空产生流体。通过调节微孔的大小和毛细管的真空度，可以灵活地控制液滴的大小。更有可能的是，微升的样品或试剂也可以从它制备成乳液。与传统方法不同，我们的设备是自激活的，避免了外部电源的需要，同时确保更少的样品或试剂消耗，简化操作和节省成本，便于即时诊断测试或现场痕量物质检测。

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来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.