Neuroprotective effect of Foeniculum vulgare essential oil in developing Wistar rats exposed to manganese chloride

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies Pub Date : 2021-11-14 DOI:10.15835/buasvmcn-asb:2021.0026

D. Adli, M. Brahmi, Kaddour Ziani, W. Arabi, K. Kahloula, M. Slimani

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Abstract

The present study was carried out in order to evaluate, on the one hand, the modifications induced by manganese chloride according to a neurobehavioral, biochemical and histological approach in developing Wistar rats and, on the other hand, to test the effectiveness of Foeniculum vulgare (fennel) essential oil (FEO) in restoring or not the harmful effects of manganese chloride (MnCl2). The characterization of this essential oil by gas chromatography showed that the major component is E-anethole (34.7907%). The administration of FEO corrected the depressive state, anxiety and locomotor hypoactivity respectively observed in rats exposed to MnCl2, thus, the FEO restored the activity of the various antioxidant enzymes with a clear improvement of the cerebral tissue architecture in intoxicated rats treated with FEO. In conclusion, the FEO has a beneficial effect on the nervous system of rats intoxicated with MnCl2 which justifies the importance of this oil in traditional medicine.

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小茴香精油对氯化锰暴露发育中的Wistar大鼠的神经保护作用

本研究旨在从神经行为学、生物化学和组织学角度评价氯化锰对发育中的Wistar大鼠的影响，同时考察茴香精油(FEO)对氯化锰(MnCl2)的恢复或抑制作用。气相色谱分析表明，该精油主要成分为e -茴香醚(34.7907%)。FEO分别纠正了MnCl2中毒大鼠的抑郁状态、焦虑状态和运动功能低下状态，从而恢复了中毒大鼠各种抗氧化酶的活性，并明显改善了脑组织结构。综上所述，FEO对MnCl2中毒大鼠的神经系统有良好的影响，证明了该油在传统医学中的重要性。

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Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies

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8 weeks