Mu opioid receptor gene (OPRM1) moderates the influence of perceived parental attention on social support seeking

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-06-08 DOI:10.1007/s40750-022-00192-w

Shaofeng Zheng, Keiko Ishii, Takahiko Masuda, Masahiro Matsunaga, Yasuki Noguchi, Hidenori Yamasue, Yohsuke Ohtsubo

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Abstract

Objective

Caring, sensitive parenting is known to be associated with higher levels of engagement in support-seeking behaviors among children and young adolescents. However, no study has yet explored the role of perceived parental attention in social support seeking in early adulthood. Growing evidence suggests that the µ-opioid receptor gene polymorphism (OPRM1 A118G) moderates one’s responsiveness to social environments. Prompted by the differential susceptibility theory of gene–environment interaction, the present study examined whether the OPRM1 polymorphism would moderate the association between perceived parental attention and social support seeking in early adulthood.

Methods

Six hundred and twenty Japanese undergraduate students self-reported the amount of attention they subjectively perceived their parents to have given them during childhood and completed scales that assess support-seeking behaviors. Clippings of their fingernails were collected for genotyping.

Results

The results showed that the interactive effect of perceived parental attention and OPRM1 genotypes on social support seeking was significant. Specifically, perceived parental attention only significantly and positively predicted OPRM1 GG carriers’ social support seeking in response to stress.

Conclusions

The findings support the view that OPRM1 polymorphism moderates the association between early experiences and developmental outcomes.

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Mu阿片受体基因（OPRM1）调节父母关注对社会支持寻求的影响

众所周知，关爱、敏感的育儿方式与儿童和青少年更高程度的寻求支持行为有关。然而，目前还没有研究探讨父母关注在成年早期寻求社会支持中的作用。越来越多的证据表明，µ-阿片受体基因多态性（OPRM1 A118G）调节了一个人对社会环境的反应。在基因-环境相互作用的差异易感性理论的推动下，本研究检验了OPRM1多态性是否会调节成年早期感知到的父母关注和寻求社会支持之间的关联。方法620名日本大学生自我报告他们主观上认为父母在童年时期给予他们的关注程度，并完成评估寻求支持行为的量表。采集他们指甲的剪片进行基因分型。结果父母关注感与OPRM1基因型对社会支持寻求的交互作用显著。具体而言，感知到的父母关注仅显著且积极地预测了OPRM1 GG携带者对压力的社会支持寻求。结论研究结果支持了OPRM1多态性调节早期经历和发育结果之间关系的观点。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.