Effect of dissolution rate and subsequent ion release on cytocompatibility properties of borophosphate glasses

Q1 Materials Science Biomedical Glasses Pub Date : 2019-01-01 DOI:10.1515/bglass-2019-0008
N. Sharmin, M. S. Hasan, M. Islam, C. Pang, Fu Gu, A. Parsons, I. Ahmed
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引用次数: 7

Abstract

Abstract Present work explores the relationship between the composition, dissolution rate, ion release and cytocompatibility of a series of borophosphate glasses. While, the base glass was selected to be 40mol%P2O5-16mol%CaO-24mol%MgO-20mol%Na2O, three B2O3 modified glass compositions were formulated by replacing Na2O with 1, 5 and 10 mol% B2O3. Ion release study was conducted using inductively coupled plasma atomic emission spectroscopy (ICP-AES). The thermal scans of the glasses as determined by differential scanning calorimetry (DSC) revealed an increment in the thermal properties with increasing B2O3 content in the glasses. On the other hand, the dissolution rate of the glasses decreased with increasing B2O3 content. To identify the effect of boron ion release on the cytocompatibility properties of the glasses, MG63 cells were cultured on the surface of the glass discs. The in vitro cell culture study suggested that glasses with 5 mol% B2O3 (P40B5) showed better cell proliferation and metabolic activity as compares to the glasses with 10 mol% (P40B10) or with no B2O3 (P40B0). The confocal laser scanning microscopy (CLSM) images of live/dead stained MG63 cells attached to the surface of the glasses also revealed that the number of dead cells attached to P40B5 glasses were significantly lower than both P40B0 and P40B10 glasses.
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溶解速率和随后的离子释放对硼磷酸盐玻璃细胞相容性的影响
摘要本文研究了一系列硼磷酸盐玻璃的组成、溶解速率、离子释放与细胞相容性之间的关系。选择40mol%P2O5-16mol%CaO-24mol%MgO-20mol%Na2O为基料玻璃,用1、5、10 mol% B2O3代替Na2O,配制出3种B2O3改性玻璃。利用电感耦合等离子体原子发射光谱(ICP-AES)研究离子释放。差示扫描量热法(DSC)对玻璃的热扫描结果表明,随着B2O3含量的增加,玻璃的热性能有所增加。另一方面,随着B2O3含量的增加,玻璃的溶解速率降低。为了确定硼离子释放对玻璃细胞相容性的影响,我们在玻璃盘表面培养MG63细胞。体外细胞培养研究表明,添加5 mol% B2O3 (P40B5)的玻璃比添加10 mol% (P40B10)或不添加B2O3 (P40B0)的玻璃具有更好的细胞增殖和代谢活性。通过共聚焦激光扫描显微镜(CLSM)对附着在P40B5和P40B10玻璃表面的MG63细胞进行观察,发现附着在P40B5玻璃表面的MG63细胞死亡数量明显低于P40B0和P40B10玻璃表面。
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
自引率
0.00%
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审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
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