Utero-Vesical Fistula Closure after 3 Weeks Treatment with Intravenous Mesenchymal Stem Cells Infusion: Case Report

M. Di Silvio, J. E. Luján-Irastorza, C. Durand-Montaño, Roberto Henández-Ramos, J. Barrón-Vallejo, Daniela Ávila-Rebollar, Julio Myslabodski, Maruxa Pariente-Fernández, Jorge Mario Tagle-Rodríguez, Miguel Ángel Ramírez-Amezcua, María Angélica Paredes-Núñez, V. Vargas-Hernández
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Abstract

Objective: To describe the evolution of Utero-Vesical Fistula (UVF) of one patient who received conservative treatment using intravenous (IV) infusion of 120x106 Adipose tissue Mesenchymal Stem Cells (ADMSCs). Clinical case report: A 36-year-old female presented with postcesarean hematuria 3 hours after an emergency c-section was performed consequently to placental abruption during labor. The primary measure was to use a transurethral Silastic 18F Foley catheter to prevent bladder expansion. The catheter remained for 21 days. Evaluation through Computerized Tomography Cystography (Cysto-CT) revealed failure to close the fistula. The decision to inject ADMSCs as an IV single dose was done. Three weeks after this intervention no blood was seen in the urine drainage bag. Complete resolution of UVF was confirmed with a control CT urogram. Result: Total closure of UVF. Conclusions: The IV infusion of ADMSCs proved to be a plausible and effective conservative treatment of UVF.
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静脉间充质干细胞输注治疗3周后子宫膀胱瘘闭合:1例报告
目的:描述1例经静脉(IV)输注120x106脂肪组织间充质干细胞(ADMSCs)保守治疗的患者子宫膀胱瘘(UVF)的演变。临床病例报告:一名36岁女性在分娩过程中因胎盘早剥紧急剖腹产3小时后出现剖宫产后血尿。主要措施是使用经尿道硅胶18F Foley导尿管来防止膀胱扩张。导管放置21天。通过计算机断层膀胱造影(膀胱ct)评估显示瘘关闭失败。决定以单剂量静脉注射ADMSCs。干预后三周,尿引流袋内未见血。通过对照CT检查证实UVF完全消退。结果:UVF完全闭合。结论:静脉输注ADMSCs是一种可行且有效的UVF保守治疗方法。
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