The effect of cobalt oxide nanoparticles on improving the quality of CT and PET scan medical imaging

Abstract

Abstract Background: Sometimes, a patient is referred to a medical imaging center and receives a medical image that it is not good and sometimes poor quality image, which the doctor orders to re-image with a drug contrast agent (in CT scan imaging). On the other hand, small liver tumors sometimes have to reach 4 cm to be detectable. At this time, practical action is difficult to provide a proper image. Moreover, injectable tracking materials in PET scans often have short half-lives that are very expensive to maintain. Purpose: -Investigation of the effect of cobalt oxide nanoparticles on the quality of CT scan images from laboratory mice. -Evaluation of the effect of cobalt oxide nanoparticles on the quality of live PET scan images and diagnosis of small tumors in mice. Method: In this study, the coupling method was used to prepare the cobalt oxide nanoparticles. Co3O4 nanoparticle coatings are used for this purpose. They were investigated through FT-IR analysis, X-ray diffraction and magnetization curve of the crystalline sample. For this purpose a 2000 μA proton bombardment with an energy of 22 million eV and a current of 180 μA was used. The final product activity was 23 mM. A. The nanoparticles were injected into Mice with tumors in the legs, and PET images were obtained at 1, 6, 12, and 24 h intervals. Results: 1- After injection the cobalt oxide nanoparticles into the mice and CT scan imaging, the better clarity and detection Mice viscera were obtained. 2-Cobalt oxide nanoparticles showed good performance in PET scan images after injection into mice in the first first 24 hours. Conclusion: Cobalt oxide nanoparticles behave well for use as a pharmacological contrast agent in CT scan and PET scan imaging. Keywords: PET, tumor, Radiotracer, nanoparticles, CT-Scan.