{"title":"OXIDATIVE DEGRADATION OF TAVABOROLE: DETERMINATION BY DERIVATIVE UV SPECTROPHOTOMETRY","authors":"Mrinalini C. Damle, Mayuri H. Suryawanshi","doi":"10.53879/id.60.06.13169","DOIUrl":null,"url":null,"abstract":"The aim of the present work was to investigate degradation behavior of tavaborole upon exposure to oxidative conditions using first order derivative UV spectrophotometric method. We have developed simple and fast analytical method that can be used as quality control tool for the determination of tavaborole. The method was based on oxidative studies over a period of time. The order of oxidative degradation reaction was calculated by using the log of recovered concentration obtained from the oxidative degradation study. The reaction was first order kinetics. The method was validated according to ICH guidelines. The linear response was found in the concentration range of 5-25 µg mL-1 at 271 nm. The % relative standard deviation (RSD) for precision studies of intraday and interday was ","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"INDIAN DRUGS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53879/id.60.06.13169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of the present work was to investigate degradation behavior of tavaborole upon exposure to oxidative conditions using first order derivative UV spectrophotometric method. We have developed simple and fast analytical method that can be used as quality control tool for the determination of tavaborole. The method was based on oxidative studies over a period of time. The order of oxidative degradation reaction was calculated by using the log of recovered concentration obtained from the oxidative degradation study. The reaction was first order kinetics. The method was validated according to ICH guidelines. The linear response was found in the concentration range of 5-25 µg mL-1 at 271 nm. The % relative standard deviation (RSD) for precision studies of intraday and interday was
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