{"title":"The antioxidant effect of Sidr (Zizyphusspina-christi) leaf extract helping to improve thescopolamine induced memory impairment in male rats","authors":"Mostafa Notarki, M. Setorki, Z. Hooshmandi","doi":"10.22034/IJPS.2017.31129","DOIUrl":null,"url":null,"abstract":"Medicinal plants have attracted global attention due to their high levels of antioxidant components for prohibiting or improving various diseases including brain and memory disorders. This study was designed to investigate if the antioxidant effect of Sidr (Zizyphusspina-christi) extract can help to improve the scopolamine induced impairment of memory in Wistar rats. Animals were randomly divided into 6 groups: Control, Scopolamine at 1 mg/kg, Scopolamine+50 mg/kg Sidr extract (Zsc50+sco), Scopolamine+100 mg/kg Sidr extract (Zsc100+sco), Scopolamine+200 mg/kg Sidr extract (Zsc200+sco) and Scopolamine+diazepam at 1 mg/kgbw (D+sco). Antioxidant activity and total phenolic content of Z. spina-christi as well as the Passive avoidance test, antioxidant capacity and MDA level of plasma and brain were evaluated.Scopolamine increased the recorded initial latencies but decrease the step-through latency in comparison with those of control group. The use of Sidr at 50, 100 and 200 mg/kg attenuate these abnormalities and the impaired passive avoidance memory was improved. Although scopolamine didn’t cause any change in the antioxidant capacity plasma and brain, it increased the MDA level of plasma and brain tissues. Also use of Sidr increased the antioxidant capacity and decreased the MDA level of plasma and brain tissues.The results suggest that Z. SC might act to attenuate scopolamine induced brain and memory impairments due to its high antioxidant contents. The separation of the specific compound responsible for observed antioxidant activity with protective effect against brain and memory disorders still need further researches.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"13 1","pages":"13-24"},"PeriodicalIF":0.0000,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22034/IJPS.2017.31129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 2
Abstract
Medicinal plants have attracted global attention due to their high levels of antioxidant components for prohibiting or improving various diseases including brain and memory disorders. This study was designed to investigate if the antioxidant effect of Sidr (Zizyphusspina-christi) extract can help to improve the scopolamine induced impairment of memory in Wistar rats. Animals were randomly divided into 6 groups: Control, Scopolamine at 1 mg/kg, Scopolamine+50 mg/kg Sidr extract (Zsc50+sco), Scopolamine+100 mg/kg Sidr extract (Zsc100+sco), Scopolamine+200 mg/kg Sidr extract (Zsc200+sco) and Scopolamine+diazepam at 1 mg/kgbw (D+sco). Antioxidant activity and total phenolic content of Z. spina-christi as well as the Passive avoidance test, antioxidant capacity and MDA level of plasma and brain were evaluated.Scopolamine increased the recorded initial latencies but decrease the step-through latency in comparison with those of control group. The use of Sidr at 50, 100 and 200 mg/kg attenuate these abnormalities and the impaired passive avoidance memory was improved. Although scopolamine didn’t cause any change in the antioxidant capacity plasma and brain, it increased the MDA level of plasma and brain tissues. Also use of Sidr increased the antioxidant capacity and decreased the MDA level of plasma and brain tissues.The results suggest that Z. SC might act to attenuate scopolamine induced brain and memory impairments due to its high antioxidant contents. The separation of the specific compound responsible for observed antioxidant activity with protective effect against brain and memory disorders still need further researches.
期刊介绍:
Iranian Journal of Pharmaceutical Sciences (IJPS) is an open access, internationally peer-reviewed journal that seeks to publish research articles in different pharmaceutical sciences subdivisions: pharmacology and toxicology, nanotechnology, pharmaceutics, natural products, biotechnology, pharmaceutical chemistry, clinical pharmacy and other pharmacy related topics. Each issue of the journal contents 16 outstanding research articles in area of pharmaceutical sciences plus an editorial written by the IJPS editors on one of the most up to date advances topics in pharmacy. All articles published by IJPS would be permanently accessible online freely without any subscription charges. Authors of the published articles have granted the right to use and disseminate their article to third parties.