The antioxidant effect of Sidr (Zizyphusspina-christi) leaf extract helping to improve thescopolamine induced memory impairment in male rats

Q4 Pharmacology, Toxicology and Pharmaceutics Iranian Journal of Pharmaceutical Sciences Pub Date : 2017-04-01 DOI:10.22034/IJPS.2017.31129
Mostafa Notarki, M. Setorki, Z. Hooshmandi
{"title":"The antioxidant effect of Sidr (Zizyphusspina-christi) leaf extract helping to improve thescopolamine induced memory impairment in male rats","authors":"Mostafa Notarki, M. Setorki, Z. Hooshmandi","doi":"10.22034/IJPS.2017.31129","DOIUrl":null,"url":null,"abstract":"Medicinal plants have attracted global attention due to their high levels of antioxidant components for prohibiting or improving various diseases including brain and memory disorders. This study was designed to investigate if the antioxidant effect of Sidr (Zizyphusspina-christi) extract can help to improve the scopolamine induced impairment of memory in Wistar rats. Animals were randomly divided into 6 groups: Control, Scopolamine at 1 mg/kg, Scopolamine+50 mg/kg Sidr extract (Zsc50+sco), Scopolamine+100 mg/kg Sidr extract (Zsc100+sco), Scopolamine+200 mg/kg Sidr extract (Zsc200+sco) and Scopolamine+diazepam at 1 mg/kgbw (D+sco). Antioxidant activity and total phenolic content of Z. spina-christi as well as the Passive avoidance test, antioxidant capacity and MDA level of plasma and brain were evaluated.Scopolamine increased the recorded initial latencies but decrease the step-through latency in comparison with those of control group. The use of Sidr at 50, 100 and 200 mg/kg attenuate these abnormalities and the impaired passive avoidance memory was improved. Although scopolamine didn’t cause any change in the antioxidant capacity plasma and brain, it increased the MDA level of plasma and brain tissues. Also use of Sidr increased the antioxidant capacity and decreased the MDA level of plasma and brain tissues.The results suggest that Z. SC might act to attenuate scopolamine induced brain and memory impairments due to its high antioxidant contents. The separation of the specific compound responsible for observed antioxidant activity with protective effect against brain and memory disorders still need further researches.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"13 1","pages":"13-24"},"PeriodicalIF":0.0000,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22034/IJPS.2017.31129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 2

Abstract

Medicinal plants have attracted global attention due to their high levels of antioxidant components for prohibiting or improving various diseases including brain and memory disorders. This study was designed to investigate if the antioxidant effect of Sidr (Zizyphusspina-christi) extract can help to improve the scopolamine induced impairment of memory in Wistar rats. Animals were randomly divided into 6 groups: Control, Scopolamine at 1 mg/kg, Scopolamine+50 mg/kg Sidr extract (Zsc50+sco), Scopolamine+100 mg/kg Sidr extract (Zsc100+sco), Scopolamine+200 mg/kg Sidr extract (Zsc200+sco) and Scopolamine+diazepam at 1 mg/kgbw (D+sco). Antioxidant activity and total phenolic content of Z. spina-christi as well as the Passive avoidance test, antioxidant capacity and MDA level of plasma and brain were evaluated.Scopolamine increased the recorded initial latencies but decrease the step-through latency in comparison with those of control group. The use of Sidr at 50, 100 and 200 mg/kg attenuate these abnormalities and the impaired passive avoidance memory was improved. Although scopolamine didn’t cause any change in the antioxidant capacity plasma and brain, it increased the MDA level of plasma and brain tissues. Also use of Sidr increased the antioxidant capacity and decreased the MDA level of plasma and brain tissues.The results suggest that Z. SC might act to attenuate scopolamine induced brain and memory impairments due to its high antioxidant contents. The separation of the specific compound responsible for observed antioxidant activity with protective effect against brain and memory disorders still need further researches.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
西柏叶提取物对改善东莨菪碱诱导的雄性大鼠记忆损伤的抗氧化作用
药用植物因其富含抗氧化成分,可预防或改善多种疾病,包括大脑和记忆障碍,而受到全球的关注。本研究旨在探讨茜草提取物对东莨菪碱致Wistar大鼠记忆损伤的抗氧化作用。实验动物随机分为6组:对照组、东莨菪碱1 mg/kg、东莨菪碱+50 mg/kg Sidr提取物(Zsc50+sco)、东莨菪碱+100 mg/kg Sidr提取物(Zsc100+sco)、东莨菪碱+200 mg/kg Sidr提取物(Zsc200+sco)和东莨菪碱+地西泮1 mg/kgbw (D+sco)。采用抗氧化活性、总酚含量、被动回避试验、抗氧化能力、血浆和脑组织MDA水平进行测定。与对照组相比,东莨菪碱增加了记录的初始潜伏期,但减少了步进潜伏期。50mg /kg、100mg /kg和200mg /kg剂量的Sidr可减弱这些异常,并改善受损的被动回避记忆。东莨菪碱对大鼠血浆和脑组织抗氧化能力无明显影响,但使血浆和脑组织MDA水平升高。同时,Sidr的使用增加了抗氧化能力,降低了血浆和脑组织的MDA水平。结果表明,黄芪多糖具有抗氧化作用,可减轻东莨菪碱引起的脑和记忆损伤。所观察到的对大脑和记忆障碍具有保护作用的抗氧化活性的特定化合物的分离仍需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Iranian Journal of Pharmaceutical Sciences
Iranian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.50
自引率
0.00%
发文量
0
期刊介绍: Iranian Journal of Pharmaceutical Sciences (IJPS) is an open access, internationally peer-reviewed journal that seeks to publish research articles in different pharmaceutical sciences subdivisions: pharmacology and toxicology, nanotechnology, pharmaceutics, natural products, biotechnology, pharmaceutical chemistry, clinical pharmacy and other pharmacy related topics. Each issue of the journal contents 16 outstanding research articles in area of pharmaceutical sciences plus an editorial written by the IJPS editors on one of the most up to date advances topics in pharmacy. All articles published by IJPS would be permanently accessible online freely without any subscription charges. Authors of the published articles have granted the right to use and disseminate their article to third parties.
期刊最新文献
Cytotoxic effect of Tilia dasystyla and Polygonatum orientale Desf extracts on AGS and SKOV-3 cancer cell lines Antibacterial Properties and Flavonoids Content of Some Mosses Common in Armenia Formulation, characterization and evaluation to establish the bioavailability of gastroretentive mucoadhesive dosage of atenolol in human subjects with possible in-vitro-in-vivo correlation Persicoimidate isolated from Allium ampeloprasum Subsp. Persicum with Apoptotic effects against Breast cancer cell lines Information Sharing and Information Quality in the Drugs and Medical Consumables Supply Chain Management (SCM)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1