{"title":"Developing dietary fiber moringa gum based ciprofloxacin encapsulated hydrogel wound dressings for better wound care","authors":"Baljit Singh , Ashima Sharma , Nistha Thakur , Rajesh Kumar","doi":"10.1016/j.fhfh.2023.100128","DOIUrl":null,"url":null,"abstract":"<div><p>Keeping in view inherent wound healing potential of moringa gum (MG), in present research, it has been applied in development of hydrogel wound dressings encapsulated with antibiotic drug ciprofloxacin for better wound care .The copolymeric hydrogels were characterized by SEMs, AFM, FTIR, XRD, <sup>13</sup>C NMR, TGA and DSC. SEM, AFM and XRD demonstrated porous morphology with rough surface having amorphous state of copolymers. Hydrogel dressings absorbed 7.71± 0.06 g/g simulated wound fluid to maintain moist wound surrounding. The diffusion of ciprofloxacin was non Fickian type from copolymer. They also exhibited mucoadhesive (3.15 ± 0.67 N s work of adhesion) and antioxidant (91.44 ± 2.89% scavenging in DPPH assay) properties. Dressings were permeable to H<sub>2</sub>O, O<sub>2</sub> and impermeable to microbes. These characteristic properties of hydrogel dressings revealed that dietary fiber moringa gum could be applied as wound dressing materials for better wound health.</p></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"3 ","pages":"Article 100128"},"PeriodicalIF":4.6000,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Hydrocolloids for Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667025923000134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 3
Abstract
Keeping in view inherent wound healing potential of moringa gum (MG), in present research, it has been applied in development of hydrogel wound dressings encapsulated with antibiotic drug ciprofloxacin for better wound care .The copolymeric hydrogels were characterized by SEMs, AFM, FTIR, XRD, 13C NMR, TGA and DSC. SEM, AFM and XRD demonstrated porous morphology with rough surface having amorphous state of copolymers. Hydrogel dressings absorbed 7.71± 0.06 g/g simulated wound fluid to maintain moist wound surrounding. The diffusion of ciprofloxacin was non Fickian type from copolymer. They also exhibited mucoadhesive (3.15 ± 0.67 N s work of adhesion) and antioxidant (91.44 ± 2.89% scavenging in DPPH assay) properties. Dressings were permeable to H2O, O2 and impermeable to microbes. These characteristic properties of hydrogel dressings revealed that dietary fiber moringa gum could be applied as wound dressing materials for better wound health.
考虑到辣木胶(MG)固有的伤口愈合潜力,本研究将其应用于抗生素药物环丙沙星包封的水凝胶伤口敷料的开发,以提高伤口护理效果。采用sem、AFM、FTIR、XRD、13C NMR、TGA和DSC对共聚水凝胶进行了表征。SEM、AFM和XRD表征了共聚物的多孔形态,表面粗糙,具有非晶态。水凝胶敷料吸收7.71±0.06 g/g模拟创面液,保持创面周围湿润。环丙沙星在共聚物中的扩散为非菲克型。它们还具有黏附(3.15±0.67 N s)和抗氧化(91.44±2.89%的DPPH清除率)的特性。敷料对H2O、O2具有渗透性,对微生物具有不渗透性。这些特性表明,膳食纤维辣木胶可作为伤口敷料,改善伤口健康。