Effect of icaritin on ferroptosis of bone marrow mesenchymal stem cells and their differentiation into cardiomyocytes

Q4 Medicine 中国组织工程研究 Pub Date : 2021-05-08 DOI:10.3969/J.ISSN.2095-4344.2194

Lihua Qi, Sun Guicai

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Abstract

BACKGROUND: Iron accumulation or iron overload is closely related to the proliferation and apoptosis of bone marrow mesenchymal stem cells, which may play an important role in the pathological process of cardiovascular diseases. OBJECTIVE: To investigate the regulatory effect of icariin on ferroptosis of bone marrow mesenchymal stem cells and its differentiation into cardiomyocytes. METHODS: Taking bone marrow mesenchymal stem cells as the research object, the blank group was cultured for 14 days. The model group was treated with https://doi.org/10.3969/j.issn. 2095-4344.2194 投稿日期:2020-04-28 送审日期:2020-04-30 采用日期:2020-05-28 在线日期:2020-09-17 中图分类号: R459.9;R394.2;R318 文章编号: 2095-4344(2021)13-01988-05 文献标识码:A 1 哈尔滨医科大学附属肿瘤医院,黑龙江省哈尔滨市 150000; 南昌大学第一附属医院,江西省南昌市 330003 第一作者:李琦,女,1986 年生,山东省莱州市人,汉族,2010 年哈尔滨医科大学毕业,医师,主要从事心电学方面的研究。通讯作者:孙贵才,博士,主任中医师,南昌大学第一附属医院,江西省南昌市 330003 https://orcid.org/0000-0002-1515-9378( 孙贵才 ) 基金资助:国家自然科学基金 (81960881,81660801),项目负责人:孙贵才引用本文:李琦,孙贵才 . 淫羊藿苷对骨髓间充质干细胞铁死亡及向心肌样细胞分化的影响 [J]. 中国组织工程研究,2021, 25(13):1988-1992. 研究原著

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淫羊藿素对骨髓间充质干细胞凋亡及向心肌细胞分化的影响

Background: Iron accumulation or iron overload is closely related to the promotion and overlap of bone marrow mesenchymal stem cells, which may play an important role in the pathological process of cardiovascular diseases OBJECTIVE: To invest the regulatory effect of icariin on ferroptosis of bone marrow mesenchymal stem cells and its differentiation into cardiomyocytes THODS: Taking bone marrow mesenchymal stem cells as the research object, the blank group was cultured for 14 days The model group was treated with https://doi.org/10.3969/j.issn. 2095-4344.2194 Submission date: April 28th, 2020 Submission date: April 30th, 2020 Adoption date: May 28th, 2020 Online date: September 17th, 2020 Classification number: R459.9; R394.2; R318 Article ID: 2095-4344 (2021) 13-01988-05 Literature ID: A 1 Harbin Medical University Affiliated Oncology Hospital, Harbin City, Heilongjiang Province, 150000; The First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, 330003. First author: Li Qi, female, born in 1986, from Laizhou City, Shandong Province, Han nationality, graduated from Harbin Medical University in 2010. Physician, mainly engaged in research in electrocardiology. Corresponding author: Sun Guicai, PhD, Chief Traditional Chinese Medicine Physician, First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, 330003 https://orcid.org/0000-0002-1515-9378 (Sun Guicai) Funded by the National Natural Science Foundation of China (8196088181660801), project leader: Sun Guicai Cited this article: Li Qi, Sun Guicai The effect of icariin on ferroptosis and differentiation into cardiomyocytes of bone marrow mesenchymal stem cells [J] Chinese Tissue Engineering Research, 2021, 25 (13): 1988-1992 Research Original Works

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来源期刊

中国组织工程研究 Medicine-Orthopedics and Sports Medicine

CiteScore

0.30

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0.00%

发文量

61083

期刊介绍： Chinese Journal of Tissue Engineering Research (CJTER) is supervised by the Ministry of Health, and sponsored by the Chinese Association of Rehabilitation Medicine and the Editorial Board of CJTER. CJTER is publishing the latest progress in tissue engineering research.Our main sections include stem cells, tissue constructions, biomaterials, orthopedic implants,digital orthopedics,organ tissue and cell transplantation. Efficiency of publication: All manuscripts accepted will be reviewed within 1 month.Time from acceptance to publishing is 3 months for excellent manuscripts, and 6 months for normal manuscripts.