Multivariate analysis of the incidence of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt

Abstract

Objective To analyze the correlation between the clinical characteristics and the incidence of postoperative hepatic encephalopathy in patients with cirrhosis who received transjugular intrahepatic portosystemic shunt (TIPS). Methods The clinical data of 80 patients with liver cirrhosis hospitalized in the Fifth Medical Center of PLA General Hospital from March 2015 to March 2017 were retrospectively analyzed.The related factors of hepatic encephalopathy complications after TIPS treatment were analyzed. Results The cumulative incidence of hepatic encephalopathy was about 23.75% (19/80) in one year after TIPS operation.Through single factor analysis and multi factor Logistic regression analysis, it was found that the two factors of preoperative platelet level and the location of tips blood shunt were closely related to the occurrence of hepatic encephalopathy after TIPS operation.The ROC curve suggested that the AUC of preoperative platelet level and the location of tips blood shunt were 0.657 and 0.668, respectively.The sensitivity and specificity of the former were 70.0%, 52.6% and the cutoff value was 51×109/L, respectively, while those of the latter were 70.5% and 63.2%, respectively. Conclusion Preoperative platelets level>51×109/L or shunting of the left branches of the portal vein may indicate a lower incidence of hepatic encephalopathy. Key words: Transjugular intrahepatic portosystemic shunt; Hepatic encephalopathy; Liver cirrhosis