Effect of Topical Antiinflammatory Drugs on Mechanical Behavior of Rabbit Cornea

D. Lepore, R. De Santis, M. Pagliara, A. Gloria, Olimpia Oliviero, C. Nucci, G. Improta, M. Triassi, L. Ambrosio
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引用次数: 7

Abstract

Background A variety of antiinflammatory therapies are employed to promote corneal wound healing. The effects of steroidal and nonsteroidal antiinflammatory drugs on the biomechanical properties of rabbit cornea were investigated over time using tensile tests. Methods Full-thickness incisions were made and used to analyze the effects of dexamethasone sodium phosphate 0.1% and diclofenac sodium 0.1% on corneal biomechanical properties during wound healing at 7, 14 and 21 days after surgery. Results The full-thickness incision deeply modified all of the mechanical properties. At 3 weeks after incision, regardless of the drug therapy, the tensile modulus was about 70% of the value for the intact cornea. Conclusions Topical treatment with dexamethasone was particularly effective during the first week after surgery; the second week after surgery, a similar result was observed in the corneas treated with diclofenac. Low doses of steroidal and nonsteroidal antiinflammatory drugs would seem to have the potential to improve biomechanical properties only during the early stage of the healing process of the cornea.
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局部抗炎药物对兔角膜力学行为的影响
背景采用多种抗炎疗法促进角膜伤口愈合。通过拉伸试验研究了甾体和非甾体抗炎药对兔角膜生物力学特性的影响。方法制作全厚切口,分析0.1%地塞米松磷酸钠和0.1%双氯芬酸钠对术后7、14和21天角膜生物力学性能的影响。结果全厚切口对所有力学性能均有较大的改善。在切口后3周,无论药物治疗如何,拉伸模量约为完整角膜值的70%。结论地塞米松局部治疗在术后第一周尤为有效;术后第二周,在用双氯芬酸治疗的角膜中观察到类似的结果。低剂量的甾体和非甾体抗炎药似乎只有在角膜愈合过程的早期阶段才有可能改善生物力学特性。
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来源期刊
Journal of Applied Biomaterials & Biomechanics
Journal of Applied Biomaterials & Biomechanics 生物-材料科学:生物材料
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