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Flow investigation of second grade micropolar nanofluid with porous medium over an exponentially stretching sheet 二级微极性纳米流体在多孔介质上的流动研究
Pub Date : 2022-04-01 DOI: 10.1177/22808000221089782
Aamir Abbas Khan, Muhammad Naveed Khan, N. A. Ahammad, Muhammad Ashraf, Kamel Guedri, A. Galal
This article mainly focuses on the influence of heat and mass transportation of micropolar second grade nanofluid toward porous medium of an exponentially stretched surface. The significance of activation energy and viscous dissipation with magnetic effect are taken into deliberated. Furthermore, to analyze the heat and mass transport scrutiny the concentration and thermal slip boundary conditions are assessed on the surface of the sheet. The convenient similarity variables are adopted to transfer the non-linear governing PDEs into the dimensionless ODEs and their corresponding boundary conditions also transformed. The nonlinear coupled ODEs are numerically solved by the usage of BVP4C MATLAB technique. The obtained numerical estimations are displayed graphically to display the significance of the various parameters against the velocity, temperature, microrotation, concentration distributions. It is noticed that larger estimations of micropolar and second grade parameter improves the fluid velocity consequently, while opposite trend is found for the higher estimation of porous medium parameter. Further, it is observed that the skin friction rate is boosted by the increment of ε and β , whereas opposite trend is noted against the mass transfer rate and heat transfer rate.
本文主要研究了微极性二级纳米流体对指数拉伸表面多孔介质的传热传质影响。考虑了活化能和黏性耗散对磁效应的影响。此外,为了分析热输运和质量输运的详细情况,评估了薄片表面的浓度和热滑移边界条件。采用方便的相似性变量将非线性控制偏微分方程转化为无量纲偏微分方程,并对其相应的边界条件进行了变换。利用BVP4C MATLAB技术对非线性耦合ode进行了数值求解。得到的数值估计以图形形式显示,以显示各种参数对速度、温度、微旋、浓度分布的重要性。微极性和二级参数的估价值越大,流体速度越快;多孔介质参数的估价值越高,流体速度越快。此外,表面摩擦率随ε和β的增加而增加,而传质率和传热率则相反。
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引用次数: 5
Influence different polishing systems on roughness and colour stability of chairside CAD/CAM blocks with laminate veneer thickness 影响不同抛光系统对椅边CAD/CAM块的粗糙度和颜色稳定性
Pub Date : 2022-01-01 DOI: 10.1177/22808000221086493
R. Sasany, Göknil Ergün Kunt, Mehmet Faruk Koca
Objective: The aim of this study was to evaluate the effect of different polishing systems on the colour stability of different laminate veneer blocks for chair-side CAD-CAM after ultraviolet (UV) ageing. Methods: About 240 sample (13 × 13 × 0.7) were prepared from four different CAD-CAM blocks IPS e.max CAD (IP), IPS Empress CAD (IE), Mark II (M) and Lava Ultimate (LU)) with A1 shade. Each group was divided into five subgroups (n = 12) according to the control (C) and four different polishing system: Sof-Lex (S), Edenta (E), Identoflex (I) and Zircon Brite (Z). Surface roughnesses (Ra) were measured by a profilometer before and after polishing. The baseline colour values were recorded according to the CIELab system. The colour coordinates (L*, a* and b*) of the samples were measured before and after UV ageing, and colour differences (ΔE00) were calculated by using the CIEDE2000 colour difference formula. A two-way ANOVA and Tukey test methods were used to analyse the data (α = 0.05). Results: A significant interaction was observed between CAD-CAM blocks and polishing system (p < 0.001). The higher Ra and colour difference was calculated in LU in the Z group after polished and the lower Ra and colour difference was calculated in the IP in the S group after polished. For the IP group, the glazing procedure showed higher Ra and ΔE values with Z group than polished S system, whereas there is no statistical differences. Conclusion: It is concluded that polishing with the Sof-Lex system improves significantly smoothness and colour stability. However, there is no success in using the Zircon Brite polishing system.
目的:本研究的目的是评估紫外线(UV)老化后,不同抛光系统对椅子侧CAD-CAM用不同层压单板块颜色稳定性的影响。方法:约240个样本(13 × 13 × 0.7)由具有A1阴影的四个不同的CAD-CAM块IPS e.max CAD(IP)、IPS Empress CAD(IE)、Mark II(M)和Lava Ultimate(LU)制备。每组分为5个亚组(n = 12) 根据对照(C)和四种不同的抛光系统:Sof Lex(S)、Edenta(E)、Identflex(I)和Zircon Brite(Z)。在抛光之前和之后通过轮廓仪测量表面粗糙度(Ra)。根据CIELab系统记录基线颜色值。在紫外线老化前后测量样品的色坐标(L*、a*和b*),并使用CIEDE2000色差公式计算色差(ΔE00)。采用双向方差分析和Tukey检验方法分析数据(α = 结果:CAD-CAM块与抛光系统之间存在显著的相互作用(p < 0.001)。抛光后Z组的LU中计算出较高的Ra和色差,而抛光后S组的IP中计算出较低的Ra和温差。对于IP组,Z组的上釉程序显示出比抛光S系统更高的Ra和ΔE值,但没有统计学差异。结论:Sof-Lex系统抛光显著提高了光滑度和颜色稳定性。然而,使用锆石Brite抛光系统并没有取得成功。
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引用次数: 7
Commercially pure titanium modification to enhance corrosion behavior and osteoblast response by ECAP for biomedical applications 商业纯钛改性增强腐蚀行为和成骨细胞反应的ECAP生物医学应用
Pub Date : 2022-01-01 DOI: 10.1177/22808000221095234
P. Hashemi, E. Borhani, M. Nourbakhsh
When it comes to using bio-metals, the chemical and biocompatibility properties of titanium led to its widespread use in biomedical implants. However, pure titanium possesses lower mechanical properties than Ti alloys containing cytotoxic elements. Severe plastic deformation (SPD) techniques were able to cause a significant strength increase, corrosion behavior improvement, and the release of the alloying elements. In this study, the ECAP process was performed on commercially pure titanium with a square cross-section at two and four passes, which resulted in a finer grain size and a more uniform microstructure. In order to improve cell behaviors, etch treatment was performed to produce nano-rough and nano-texture surfaces for all Ti samples. The effect of surface etching on corrosion, surface roughness, and cell behaviors on ECAP and untreated samples was also investigated. Optical/Field Emission Scanning Electron Microscopy, Atomic Force Microscopy, and X-Ray Diffraction were used to study the microstructural characterizations of samples. In addition, the impact of grain structure on the contact angle, electrochemical corrosion behavior, osteoblast response, and cell viability was investigated. The titanium that was ECAPed four times provided finer grains (200 nm) than the unprocessed sample (25 µm). The potentiodynamic polarization test revealed that corrosion resistance of ECAPed samples was enhanced, which was associated with grain refinement, affecting the passive film formation. Corrosion resistance and wettability experienced an apparent increase after each ECAP pass. In conclusion, improvement of grain size and surface roughness was due to the simultaneous effect of ECAP and etching treatment that led to the osteoblast response and cellular activity of samples.
在使用生物金属方面,钛的化学和生物相容性使其在生物医学植入物中得到广泛应用。然而,纯钛比含有细胞毒性元素的钛合金具有更低的机械性能。严重塑性变形(SPD)技术能够显著提高强度、改善腐蚀行为和释放合金元素。在这项研究中,在两道和四道次的方形截面的商业纯钛上进行了ECAP工艺,这导致了更细的晶粒尺寸和更均匀的微观结构。为了改善细胞行为,对所有Ti样品进行了蚀刻处理,以产生纳米粗糙和纳米纹理的表面。还研究了表面蚀刻对ECAP和未处理样品的腐蚀、表面粗糙度和细胞行为的影响。使用光学/场发射扫描电子显微镜、原子力显微镜和X射线衍射来研究样品的微观结构特征。此外,还研究了颗粒结构对接触角、电化学腐蚀行为、成骨细胞反应和细胞活力的影响。四次ECAPed的钛提供了更细的晶粒(200 nm)比未处理的样品(25 µm)。动电位极化试验表明,ECAPed样品的耐蚀性增强,这与晶粒细化有关,影响了钝化膜的形成。每次ECAP后,耐腐蚀性和润湿性都明显增加。总之,ECAP和蚀刻处理的同时作用导致了样品的成骨细胞反应和细胞活性,从而改善了晶粒尺寸和表面粗糙度。
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引用次数: 3
A Copper nanoparticles-based polymeric spray coating: Nanoshield against Sars-Cov-2 一种基于铜纳米颗粒的聚合物喷涂涂层:针对严重急性呼吸系统综合征冠状病毒2型的纳米防护
Pub Date : 2022-01-01 DOI: 10.1177/22808000221076326
I. Foffa, P. Losi, Paola Quaranta, Alice Cara, T. Al Kayal, M. D’Acunto, G. Presciuttini, M. Pistello, G. Soldani
Face masks are an effective protection tool to prevent bacterial and viral transmission. However, commercial face masks contain filters made of materials that are not capable of inactivating either SARS-CoV-2. In this regard, we report the development of an antiviral coating of polyurethane and Copper nanoparticles on a face mask filter fabricated with a spray technology that is capable of inactivating more than 99% of SARS-CoV-2 particles in 30 min of contact.
口罩是防止细菌和病毒传播的有效防护工具。然而,商用口罩含有由不能灭活严重急性呼吸系统综合征冠状病毒2型的材料制成的过滤器。在这方面,我们报道了在口罩过滤器上开发的聚氨酯和铜纳米颗粒抗病毒涂层,该涂层采用喷雾技术制造,能够在30秒内灭活99%以上的严重急性呼吸系统综合征冠状病毒2型颗粒 最小接触时间。
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引用次数: 11
Swirling flow of fluid containing (SiO2) and (MoS2) nanoparticles analyze via Cattaneo-Christov theory 用Cattaneo-Christov理论分析含(SiO2)和(MoS2)纳米颗粒流体的旋流
Pub Date : 2022-01-01 DOI: 10.1177/22808000221094685
Juan Zhang, Awais Ahmed, Muhammad Naveed Khan, Fuzhang Wang, Shaimaa A M Abdelmohsen, H. Tariq
Investigation of heat transport mechanism in swirling flow of viscous fluid containing silicon dioxide ( S i O 2 ) and molybdenum disulfide ( M o S 2 ) nanoparticles is performed. The flow is engendered due to stretchable rotating cylinder which immersed in infinite fluid. The boundary layer assumption is applied to simplify the governing equations of the problem. The theory of Cattaneo-Christov for thermal energy transportation is employed in the present phenomenon under the heat and mass constraints. The flow is also influenced by Lorentz force. The results for flow field, temperature, and concentration field are produced by employing the bvp4c numerical technique to the similar differential equations. According to the observations, it is noted that in the presence of Lorentz force the reduction in velocity field of the nanofluid occurs. The thermal and solutal relaxation phenomena also declines the energy transport in nanofluid flow. The outcomes are validated through the comparison with previous published studies.
研究了含二氧化硅(Si O 2)和二硫化钼(M O S 2)纳米颗粒的粘性流体旋流中的热传输机制。流动是由于可伸缩的旋转圆柱体浸入无限大的流体中而产生的。应用边界层假设简化了问题的控制方程。在热和质量约束下,应用Cattaneo-Christov的热能传输理论来研究这一现象。流动也受到洛伦兹力的影响。将bvp4c数值技术应用于类似的微分方程,得到了流场、温度场和浓度场的结果。根据观察结果,值得注意的是,在洛伦兹力的存在下,纳米流体的速度场会减小。热弛豫和溶质弛豫现象也降低了纳米流体流动中的能量传输。通过与先前发表的研究进行比较,验证了结果。
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引用次数: 3
Effect of increasing mineralization on pre-osteoblast response to native collagen fibril scaffolds for bone tissue repair and regeneration 矿化度增加对成骨前细胞对天然胶原纤维支架骨组织修复和再生的影响
Pub Date : 2022-01-01 DOI: 10.1177/22808000221104000
Brendan H Grue, Samuel P. Veres
With limited availability of auto- and allografts, there is increasing demand for alternative bone repair and regeneration materials. Inspired by a mimetic approach, the utility of producing engineered native protein scaffolds is being increasingly realized, demonstrating the need for continued research in this field. In previous work, we detailed a process for producing mineralized collagen scaffolds using tendon to create collagen templates of highly aligned, natively crosslinked collagen fibrils. The process produced mineral phase closely matching that of native bone, and integration of mineral with the collagen template was demonstrated to be easily controlled, allowing scaffolds to be mechanically tuned. In the current study, we have extended this work to investigate how variation in the mineralization level of these scaffolds affects the osteogenic response of pre-osteoblastic cells. Scaffolds were produced under three treatment groups, where collagen templates underwent 0, 5, or 20 mineralization cycles. Scaffolds in each treatment group were cultured with MC3T3-E1 cells for 1, 7, or 14 days. Morphologic assessment under SEM indicated decreased attachment to the mineralized scaffolds, supported by DNA results showing a significant drop between culture days 1 and 7 for mineralized scaffolds only. For adherent cells, increasing scaffold mineralization also delayed cell spreading. While mineralization presented a barrier to cell coverage of scaffolds, it increased osteogenic activity, with cells on the mineralized scaffolds showing significantly greater alkaline phosphatase activity and osteocalcin production. Understanding how increasing collagen mineralization effects pre-osteoblast function may enable design of more advanced mineralized collagen scaffolds for bone repair and regeneration.
由于自体和同种异体骨移植的可用性有限,对替代骨修复和再生材料的需求日益增加。受模拟方法的启发,生产工程天然蛋白支架的效用越来越被认识到,这表明需要在这一领域继续研究。在之前的工作中,我们详细介绍了一种使用肌腱制造矿化胶原支架的过程,该支架使用高度排列的天然交联胶原原纤维来创建胶原模板。该过程产生的矿物相与天然骨非常匹配,并且矿物质与胶原模板的整合被证明是容易控制的,允许支架进行机械调节。在目前的研究中,我们扩展了这项工作,以研究这些支架矿化水平的变化如何影响成骨前细胞的成骨反应。在三个治疗组中,胶原模板分别经历了0、5或20个矿化周期。各组支架分别与MC3T3-E1细胞培养1、7、14天。扫描电镜下的形态学评估表明,与矿化支架的附着减少,DNA结果表明,仅矿化支架在培养第1天至第7天之间明显下降。对于贴壁细胞,支架矿化的增加也延迟了细胞的扩散。虽然矿化对支架细胞的覆盖构成了障碍,但它增加了成骨活性,矿化支架上的细胞显示出明显更高的碱性磷酸酶活性和骨钙素的产生。了解胶原矿化增加如何影响成骨前细胞功能,有助于设计更先进的矿化胶原支架,用于骨修复和再生。
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引用次数: 2
β-TCP/DCPD-PHBV (40%/60%): Biomaterial made from bioceramic and biopolymer for bone regeneration; investigation of intrinsic properties β-TCP/DCPD-HBV(40%/60%):由生物陶瓷和生物聚合物制成的用于骨再生的生物材料;内在性质研究
Pub Date : 2022-01-01 DOI: 10.1177/22808000221088950
Trimeche Monia
In this study, a detailed physical, chemical, and mechanical investigation of bone substitute (β-TCP/DCPD-PHBV) was carried out. In fact, it is composed of biocompatible materials such as ceramic phosphocalcic, consisting of tricalcium phosphate (β-TCP) and dihydrated dicalcium phosphate (DCPD) and 3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) polymer having a weight fraction 40%/60%. For these analyses, diverse techniques were used, including SEM-EDS, mercury porosimeter, Fourier Transform Infrared Spectroscopy, and, finally, uniaxial compression test machine. A morphological investigation of biomaterials using MEB revealed uneven particle shape and size, as well as a rough surface with a porous and microcracked structure. In fact, this architecture promotes the development of bone within biomaterials. Compositional studies applying FTIR technology, also, revealed the existence of chemical components, comparable to those found in the mineral phase of bone (Ca2+, PO43−, and HPO42−). The following compounds prove the bioactivity of β-TCP/DCPD-PHBV. Furthermore, mechanical investigations revealed that this biomaterial has a satisfying mechanical strength (195.21 MPa), closer to bone. Nevertheless, another significant benefit of combining the two biocompatible materials used in this work is that the ductility of PHBV restricts the brittleness of β-TCP/DCPD-PHBV, compared to pure β-TCP/DCPD. The obtained results demonstrate the beneficial properties of β-TCP/DCPD-PHBV and approve the possibility of using this biomaterial as a viable material for future implantology applications.
本研究对骨替代物(β-TCP/DCPD-PHBV)进行了详细的物理、化学和力学研究。事实上,它是由生物相容性材料如陶瓷磷钙组成的,由磷酸三钙(β-TCP)和二水合磷酸二钙(DCPD)和3-羟基丁酸-co-3-羟基戊酸酯(PHBV)聚合物组成,重量分数为40%/60%。为了进行这些分析,使用了多种技术,包括SEM-EDS,汞孔隙度计,傅里叶变换红外光谱,最后是单轴压缩试验机。利用MEB对生物材料进行形态学研究,发现颗粒形状和大小不均匀,表面粗糙,具有多孔和微裂纹结构。事实上,这种结构促进了骨在生物材料中的发育。利用FTIR技术进行的成分研究也揭示了与骨矿物相(Ca2+, PO43−和HPO42−)相似的化学成分的存在。以下化合物证明了β-TCP/DCPD-PHBV的生物活性。此外,力学研究表明,该生物材料具有令人满意的机械强度(195.21 MPa),更接近骨。然而,结合本研究中使用的两种生物相容性材料的另一个显著好处是,与纯β-TCP/DCPD相比,PHBV的延展性限制了β-TCP/DCPD-PHBV的脆性。实验结果证实了β-TCP/DCPD-PHBV的有益特性,并证实了这种生物材料作为未来植入材料的可行性。
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引用次数: 4
Comparative modal analysis on fishing rod made of functionally graded composite material using finite element analysis 用有限元方法对功能梯度复合材料鱼竿进行模态比较分析
Pub Date : 2022-01-01 DOI: 10.1177/22808000221089774
S. Asiri
The use of smart and advanced composite materials instead of conventional metals is foreseen in material sciences due to the development of novel manufacturing techniques. In this regard, a novel type of composite materials “functionally graded materials (FGM)” has attained great attention owing to their intrinsic mechanical characteristics. FGM have been the focus for researchers for analytical formulation, static structural (large deformation, material nonlinearity) analysis as well as for dynamic analysis on simple beams and on structure having non-uniform tapered rectangular profile considering different boundary conditions. No focus is made to thin structure having non-uniform circular cross-sections. This study aims to deal with analyzing the “dynamic behavior of thin circular non-uniform truncated conical section” which is mostly used for manufacturing of fishing rod. This works primarily compares the static, modal, and harmonic analysis under the application of loads of 50 N acting on fishing rod made up of conventional steel, composite (carbon fiber) steel, and functionally graded material (FGM) with the help of ANSYS®. Firstly, static analysis performed to analyze the structural behavior under the application of static loadings. After that modal analysis performed and first five modes selected for Steel; from 0 to 600 Hz, for Carbon Fiber; from 0 to 850 Hz and for FGM; from 0 to 900 Hz for harmonic analysis. Maximum defection at resonance for steel is 7.94 mm, for composite is 74.4 mm, and for FGM is just 0.032 mm. The comparison of these results clearly depicts that FGM is having excellent vibration suppression performance as compared to other two materials under consideration. This confirms that thin structure (non-uniform circular profile) made of FGM can be used efficiently for the intended applications in future.
由于新型制造技术的发展,材料科学预计将使用智能和先进的复合材料来代替传统金属。在这方面,一种新型的复合材料“功能梯度材料(FGM)”由于其固有的力学特性而受到了极大的关注。FGM一直是研究人员在分析公式、静态结构(大变形、材料非线性)分析以及在考虑不同边界条件的情况下对简支梁和具有非均匀锥形矩形轮廓的结构进行动态分析方面的重点。没有关注具有非均匀圆形横截面的薄结构。本研究旨在分析主要用于制造鱼竿的“薄圆形非均匀截锥截面的动力学行为”。本工作主要比较了50荷载作用下的静态、模态和谐波分析 在ANSYS®的帮助下,N作用在由传统钢、复合(碳纤维)钢和功能梯度材料(FGM)组成的鱼竿上。首先,进行了静力分析,分析了在静载荷作用下的结构性能。之后进行了模态分析,并为钢选择了前五种模态;从0到600 Hz,用于碳纤维;从0到850 Hz和FGM;从0到900 Hz用于谐波分析。钢材共振时的最大缺陷为7.94 mm,复合材料为74.4 mm,而FGM仅为0.032 这些结果的比较清楚地表明,与所考虑的其他两种材料相比,FGM具有优异的振动抑制性能。这证实了由FGM制成的薄结构(非均匀圆形轮廓)可以有效地用于未来的预期应用。
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引用次数: 0
Biodegradation behaviors of magnesium(Mg)-based alloy nails in autologous bone grafts: In vivo study in rabbit skulls 镁基合金钉在兔颅骨内的生物降解行为研究
Pub Date : 2022-01-01 DOI: 10.1177/22808000221095230
Yuta Yanagisawa, Y. Shimizu, T. Mukai, Yuya Sano, Kenji Odashima, N. Ikeo, H. Saito, K. Yamauchi, Tetsu Takahashi, H. Kumamoto
Objective: In this study, autologous bone grafts using bone-fixing nails made of magnesium-zinc-calcium ternary alloys were performed using rabbit skulls. Material and methods: Two types of nails for bone fixation were prepared: 2.5 mm width, 3 mm length and 2.5 mm width, 2 mm length. A disk-shaped bone with a diameter of 5 mm was resected from the parietal bone and fixed with a 3 mm long nail. As a control group, a 2 mm long nail was driven into the existing bone. The rabbits were sacrificed at 1, 4, 12, and 24 weeks after surgery. The resected samples were observed with micro X-ray CT, and embedded in methyl methacrylate to prepare non-decalcified specimens. The in vivo localization of elements was examined using energy-dispersive X-ray spectroscopy (EDS). Results: Micro X-ray CT images of samples showed volume reduction due to degradation in both the bone graft and control groups. No significant difference in the amount of degradation between the two groups was observed, however characteristic degradation processes were observed in each group. The samples stained with alizarin red S showed amorphous areas around the nails, which were considered as corrosion products and contacted directly with the newly formed bones. EDS analysis showed that corrosion products were mainly composed of magnesium and oxygen at an early stage, while calcium and phosphorus were detected on the surface layer during the long-term observation. Conclusions: The degradation speed of the magnesium alloy nails varied depending on the shapes of the nails and surrounding tissue conditions. A calcium phosphate layer was formed on the surface of magnesium alloy nails, suggesting that the degradation rate of the nail was slow.
目的:采用镁锌钙三元合金制骨钉,在兔颅骨上进行自体骨移植。材料和方法:制备了两种用于骨固定的钉:2.5 mm宽,3 mm长和2.5 mm宽,2 mm长。直径为5的圆盘状骨头 mm从顶骨切除并用3 mm长的钉子。作为对照组 将mm长的钉子钉入现有骨中。在1、4、12和24时处死兔子 手术后数周。切除的标本用微型X射线CT观察,并包埋在甲基丙烯酸甲酯中制备非脱钙标本。使用能量色散X射线光谱(EDS)检查元素的体内定位。结果:在骨移植组和对照组中,样品的显微X射线CT图像显示由于降解导致体积减少。两组之间的降解量没有观察到显著差异,但在每组中都观察到了特征性的降解过程。用茜素红S染色的样品在指甲周围显示出无定形区域,这些区域被认为是腐蚀产物,并与新形成的骨骼直接接触。EDS分析表明,早期腐蚀产物主要由镁和氧组成,而在长期观察中,表层检测到钙和磷。结论:镁合金指甲的降解速度随指甲形状和周围组织条件的不同而不同。镁合金指甲表面形成磷酸钙层,表明指甲的降解速度较慢。
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引用次数: 0
Preparation and properties of N-glycosylated chitosan/polyvinyl alcohol hydrogels for use in wound dressings 伤口敷料用n -糖基化壳聚糖/聚乙烯醇水凝胶的制备及性能研究
Pub Date : 2022-01-01 DOI: 10.1177/22808000221101809
Y. Yi, Ting Huang, Yunxia Xu, Jianfeng Mei, Yanlu Zhang, Xudong Wang, Jianshu Chen, Guoqing Ying
Chitosan and its derivatives show potent biocompatibility, biodegradability, antimicrobial activity, hemostatic effects, and wound healing properties. Their application in wound dressings has garnered substantial research interest. In this work, we prepared a drug-loaded hydrogel by mixing N-glycosylated chitosan with polyvinyl alcohol (PVA), followed by loading of ofloxacin. A 2:1 volume ratio of chitosan to PVA was found to be optimal based on swelling and water evaporation rates. The slow-drug-release performance of the blended hydrogel was best when the ofloxacin loading was 5.0%. The ofloxacin-loaded hydrogel shows excellent antimicrobial properties in vitro and wound healing ability in an in vivo rabbit full-thickness excision wound model. The chitosan/PVA blended hydrogel has great potential for use in wound dressings and sustained drug release.
壳聚糖及其衍生物具有良好的生物相容性、生物降解性、抗菌活性、止血作用和伤口愈合性能。它们在伤口敷料中的应用已经引起了大量的研究兴趣。本研究将n -糖基化壳聚糖与聚乙烯醇(PVA)混合,再负载氧氟沙星,制备了载药水凝胶。壳聚糖与聚乙烯醇的体积比为2:1,根据溶胀率和水分蒸发率确定最佳配比。当氧氟沙星添加量为5.0%时,混合水凝胶的缓释性能最佳。负载氧氟沙星的水凝胶在体外表现出良好的抗菌性能,并在兔全层切除伤口模型中表现出良好的伤口愈合能力。壳聚糖/聚乙烯醇混合水凝胶在伤口敷料和药物缓释方面具有很大的应用潜力。
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引用次数: 4
期刊
Journal of Applied Biomaterials & Biomechanics
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