Human Genetic Polymorphisms Contributing to Coronavirus Disease 2019 Susceptibility: A Bibliometric Analysis via CiteSpace

Abstract

A growing number of related research papers have been published in recent months about COVID-19 as a global pandemic. Research directions and hot topics can be identified by bibliometric analysis of these publications. Using the Web of Science database, we scanned the global literature about COVID-19 from 2020 to 2022.A search using keywords such as “COVID-19” and “genetic polymorphisms” led to relevant publications. A bibliometric analysis of these articles was conducted using CiteSpace. We identified 438 publications on COVID-19 with genetic polymorphisms. In terms of citation counts, Nature ranked first with 271 citations. Veronica Tisato, Giuseppe Fiorentino, Naoki Yamamoto, and Ingrid Fricke-Galindo were the most productive authors (each having 4 articles). The most cited organization is Tehran University of Medical Sciences with fourteen articles. USA is the most prolific collaborator with 76 articles. The polymorphism in the interleukin-6 gene (IL-6) was first studied in 2020. ACE2 gene polymorphism has been the focus of research since 2021. A major contribution to this field was made by the USA. The relationship of ACE2 gene G8790A polymorphism with COVID-19 and severity may be future hotspots.