Pub Date : 2024-03-01Epub Date: 2022-04-11DOI: 10.1017/ipm.2022.12
F McNicholas, D Adamis, E Minihan, N Doody, B Gavin
Background: Previous literature has highlighted high rates of burnout among doctors and nurses in healthcare settings. Non-clinical and support staff such as administrative, housekeeping and managerial staff are also exposed to the stressors of a health care setting, but fewer studies report on their experiences. Therefore, the aim of this research is to examine occupational stress in all staff working in Child and Adolescent Mental Health Services (CAMHS) in Ireland and identify risk and protective factors.
Method: Fifty-nine clinical and non-clinical staff (44% response rate) were surveyed. Participants completed the Copenhagen Burnout Inventory (CBI) and the Effort Reward Imbalance scale, as well as survey-specific questions.
Results: Both clinical and non-clinical staff were found to experience moderate or high rates of work-related, personal and patient-related burnout (57.6%, 52.2% and 50.8%, respectively). Univariate general linear modelling showed an association between total CBI scores and effort reward index (B = 64 306, t = 3.430, p = 0.001); overcommitment (B = 1.963, t = 3.061, p = 0.003); and an unwillingness to work in CAMHS (B = 28.429, t = 3.247, p = 0.002).
Conclusion: Pre-pandemic levels of stress were high among clinical and non-clinical staff surveyed. Given the anticipated increased demand on CAMHS post COVID-19, urgent action is needed to protect all staff from intolerable levels of occupational stress and burnout.
{"title":"Occupational stress in clinical and non-clinical staff in Child and Adolescent Mental Health Services (CAMHS): a cross-sectional study.","authors":"F McNicholas, D Adamis, E Minihan, N Doody, B Gavin","doi":"10.1017/ipm.2022.12","DOIUrl":"10.1017/ipm.2022.12","url":null,"abstract":"<p><strong>Background: </strong>Previous literature has highlighted high rates of burnout among doctors and nurses in healthcare settings. Non-clinical and support staff such as administrative, housekeeping and managerial staff are also exposed to the stressors of a health care setting, but fewer studies report on their experiences. Therefore, the aim of this research is to examine occupational stress in all staff working in Child and Adolescent Mental Health Services (CAMHS) in Ireland and identify risk and protective factors.</p><p><strong>Method: </strong>Fifty-nine clinical and non-clinical staff (44% response rate) were surveyed. Participants completed the Copenhagen Burnout Inventory (CBI) and the Effort Reward Imbalance scale, as well as survey-specific questions.</p><p><strong>Results: </strong>Both clinical and non-clinical staff were found to experience moderate or high rates of work-related, personal and patient-related burnout (57.6%, 52.2% and 50.8%, respectively). Univariate general linear modelling showed an association between total CBI scores and effort reward index (<i>B</i> = 64 306, <i>t</i> = 3.430, <i>p</i> = 0.001); overcommitment (<i>B</i> = 1.963, <i>t</i> = 3.061, <i>p</i> = 0.003); and an unwillingness to work in CAMHS (<i>B</i> = 28.429, <i>t</i> = 3.247, <i>p</i> = 0.002).</p><p><strong>Conclusion: </strong>Pre-pandemic levels of stress were high among clinical and non-clinical staff surveyed. Given the anticipated increased demand on CAMHS post COVID-19, urgent action is needed to protect all staff from intolerable levels of occupational stress and burnout.</p>","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"10 1","pages":"54-60"},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87024431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To assess lidocaine’s combined impact with a self-crafted hot compress cuff in diminishing venous indwelling needle injuries during otolaryngology surgeries. 70 patients undergoing otolaryngology surgeries at our hospital between July 2020 and September 2022 were chosen. All underwent venous indwelling needle procedures. Equally divided into an control group (CG) and an experimental group (EG), each with 35 cases, the CG received standard intervention with lidocaine, while the EG received additional self-made hot compress sleeves. Evaluation parameters included changes in skin temperature at the infusion site, needle indwelling duration, phlebitis incidence, needle blockage, pain, and comfort. The EG exhibited significantly higher skin temperatures at the infusion site compared to the CG (P <0.05). Needle indwelling duration was notably prolonged in the EG versus the CG (P <0.05). Phlebitis incidence was notably lower in the EG (14.29%) than the CG (37.14%) (P <0.05). No significant difference was found in needle blockage rates between groups (25.71% in CG, 17.14% in experimental) (P > 0.05). Pain scores were notably lower, and comfort scores were higher in the EG (all, P < 0.05). Combining lidocaine with a self-made hot compress cuff significantly mitigates venous indwelling needle injuries in otolaryngology surgeries. This combined approach enhances skin temperature, extends needle indwelling time, reduces phlebitis and needle blockage risks, alleviates patient discomfort, and elevates overall comfort during venous indwelling needle procedures.
{"title":"The Observation of the Effect of Lidocaine Combined with Homemade Warm Compress Sleeve in Alleviating Venous Catheter-Related Injuries in Otolaryngology Surgery Patients","authors":"Chengyan Zhang, Daolan Xu","doi":"10.1166/jbt.2024.3352","DOIUrl":"https://doi.org/10.1166/jbt.2024.3352","url":null,"abstract":"To assess lidocaine’s combined impact with a self-crafted hot compress cuff in diminishing venous indwelling needle injuries during otolaryngology surgeries. 70 patients undergoing otolaryngology surgeries at our hospital between July 2020 and September 2022 were chosen. All underwent\u0000 venous indwelling needle procedures. Equally divided into an control group (CG) and an experimental group (EG), each with 35 cases, the CG received standard intervention with lidocaine, while the EG received additional self-made hot compress sleeves. Evaluation parameters included changes\u0000 in skin temperature at the infusion site, needle indwelling duration, phlebitis incidence, needle blockage, pain, and comfort. The EG exhibited significantly higher skin temperatures at the infusion site compared to the CG (P <0.05). Needle indwelling duration was notably prolonged\u0000 in the EG versus the CG (P <0.05). Phlebitis incidence was notably lower in the EG (14.29%) than the CG (37.14%) (P <0.05). No significant difference was found in needle blockage rates between groups (25.71% in CG, 17.14% in experimental) (P > 0.05). Pain scores\u0000 were notably lower, and comfort scores were higher in the EG (all, P < 0.05). Combining lidocaine with a self-made hot compress cuff significantly mitigates venous indwelling needle injuries in otolaryngology surgeries. This combined approach enhances skin temperature, extends needle\u0000 indwelling time, reduces phlebitis and needle blockage risks, alleviates patient discomfort, and elevates overall comfort during venous indwelling needle procedures.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"27 8","pages":""},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140519931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The paper aimed to explore the effect of Tetrahydropalmatine on the activation of NLRP3 inflammasomes in BV-2 cells and its mechanism in vitro. Material and methods: ELISA determine the IL-1β and IL-18 in the BV-2 cell culture medium of each group. WB was employed to detect NLRP3 inflammasome-related components including NLRP3, ASC, NEK7 and Caspase-1, as well as p-NF-κB, NF-κB, p-Iκ-Bα and Iκ-Bα in cell lysates of each group. The effects of Tetrahydropalmatine on NLRP3 inflammasome activation and NF-κB signaling pathway were analyzed. Immunofluorescence labeling method was used to detect the expressions of NLRP3 in BV-2 cells in each group. Mito-tracker Red labeled mitochondrial confocal microscope was employed to observe and evaluate mitochondrial damage. Fluorescent probe DCFH-DA was used to label cells. Flow cytometry technology was applied to detect ROS production and evaluate the effect of Tetrahydropalmatine on ROS production. Results: After Tetrahydropalmatine treatment, p-NF-κB/NF-κB and p-Iκ-Bα/Iκ-Bα were significantly lower than that in the model group. Tetrahydropalmatine can inhibit the production of ROS and improve the mitochondrial membrane potential. Conclusion: Tetrahydropalmatine can mitigate mitochondrial damage, reduce ROS production, and inhibit the NF-κB signaling pathway, thereby inhibiting the activation of NLRP3 inflammasomes in BV-2 cells.
{"title":"In Vivo Study on the Effect of Tetrahydropalmatine on the Activation of NLRP3 Inflammasome in BV-2 Cells","authors":"Mingjuan Zhang, Xiajun Yi, Qingying Zhan, Li Huang, Yadong Xiao, Jihui Zhong","doi":"10.1166/jbt.2024.3353","DOIUrl":"https://doi.org/10.1166/jbt.2024.3353","url":null,"abstract":"Background: The paper aimed to explore the effect of Tetrahydropalmatine on the activation of NLRP3 inflammasomes in BV-2 cells and its mechanism in vitro. Material and methods: ELISA determine the IL-1β and IL-18 in the BV-2 cell culture medium of each\u0000 group. WB was employed to detect NLRP3 inflammasome-related components including NLRP3, ASC, NEK7 and Caspase-1, as well as p-NF-κB, NF-κB, p-Iκ-Bα and Iκ-Bα in cell lysates of each group. The effects of Tetrahydropalmatine\u0000 on NLRP3 inflammasome activation and NF-κB signaling pathway were analyzed. Immunofluorescence labeling method was used to detect the expressions of NLRP3 in BV-2 cells in each group. Mito-tracker Red labeled mitochondrial confocal microscope was employed to observe and evaluate\u0000 mitochondrial damage. Fluorescent probe DCFH-DA was used to label cells. Flow cytometry technology was applied to detect ROS production and evaluate the effect of Tetrahydropalmatine on ROS production. Results: After Tetrahydropalmatine treatment, p-NF-κB/NF-κB\u0000 and p-Iκ-Bα/Iκ-Bα were significantly lower than that in the model group. Tetrahydropalmatine can inhibit the production of ROS and improve the mitochondrial membrane potential. Conclusion: Tetrahydropalmatine can mitigate mitochondrial\u0000 damage, reduce ROS production, and inhibit the NF-κB signaling pathway, thereby inhibiting the activation of NLRP3 inflammasomes in BV-2 cells.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"13 6","pages":""},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140523950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faisal Ali Alqhtani, Anshad M. Abdullah, Shan Sainudeen, Rida batool, M. Kamran
Assessment of the micro tensile bond strength (μTBS) and microleakage of contemporary restorative materials (Cention N cement (CN), Bulk-fill Resin-based composite (BF-RBC), and Zirconomer Improved) bonded to carious affected dentin (CAD) of primary molars as compared to conventional control Glass ionomer cement (GIC). Eighty human primary molars having scores 4 and 5 of the International Caries Detection and Assessment System (ICDAS) were included. Specimens were randomly allocated into four groups (n = 20) Group I = GIC, Group 2: Zirconomer Improved, Group 3: CN, and Group 4: BF-RBC. All the samples were thermocycled followed by marginal leakage, μTBS, and failure mode assessment using a dye penetration test, universal testing machine, and a stereomicroscope. The μTBS and microleakage results were examined using (ANOVA) and Tukey post hoc tests. Samples from Group 1 (GIC) revealed the highest value of marginal leakage (30.55±10.31 nm) and the lowest recorded value of μTBS (12.28±0.32 MPa). In contrast, the specimens from Group 3 (CN) demonstrated the lowest levels of microleakage (14.89±4.33 nm) and highest bond integrity (18.12±0.79 MPa). Cention N cement and Bulk-fill composite have shown to be reliable options as a restorative material in primary dentition due to their superior tensile bond strength and reduced marginal leakage scores when applied to caries-affected dentin.
{"title":"Comparison of Marginal Seal and Tensile Bond Strength of an Alkasite, Zircomer, and Bulk Fill Composite to Carious Affected Primary Molars","authors":"Faisal Ali Alqhtani, Anshad M. Abdullah, Shan Sainudeen, Rida batool, M. Kamran","doi":"10.1166/jbt.2024.3351","DOIUrl":"https://doi.org/10.1166/jbt.2024.3351","url":null,"abstract":"Assessment of the micro tensile bond strength (μTBS) and microleakage of contemporary restorative materials (Cention N cement (CN), Bulk-fill Resin-based composite (BF-RBC), and Zirconomer Improved) bonded to carious affected dentin (CAD) of primary molars as compared to conventional\u0000 control Glass ionomer cement (GIC). Eighty human primary molars having scores 4 and 5 of the International Caries Detection and Assessment System (ICDAS) were included. Specimens were randomly allocated into four groups (n = 20) Group I = GIC, Group 2: Zirconomer Improved, Group 3:\u0000 CN, and Group 4: BF-RBC. All the samples were thermocycled followed by marginal leakage, μTBS, and failure mode assessment using a dye penetration test, universal testing machine, and a stereomicroscope. The μTBS and microleakage results were examined using (ANOVA) and\u0000 Tukey post hoc tests. Samples from Group 1 (GIC) revealed the highest value of marginal leakage (30.55±10.31 nm) and the lowest recorded value of μTBS (12.28±0.32 MPa). In contrast, the specimens from Group 3 (CN) demonstrated the lowest levels of microleakage (14.89±4.33\u0000 nm) and highest bond integrity (18.12±0.79 MPa). Cention N cement and Bulk-fill composite have shown to be reliable options as a restorative material in primary dentition due to their superior tensile bond strength and reduced marginal leakage scores when applied to caries-affected\u0000 dentin.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"12 3","pages":""},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study aimed to evaluate the predictive value of conventional ultrasound signs and serological indices in the detection of neck lymph node metastasis in papillary thyroid cancer (PTC). A total of 80 patients with PTC scheduled for surgery in our hospital between August 2019 and December 2022 were recruited. Patients with neck lymph node metastasis were categorized as the experimental group, and patients without neck lymph node metastasis were included in the control group. Patients’ ultrasound signs were analyzed, and serological indices were determined. Logistic analysis was performed to determine the risk factors for the development of postoperative neck lymph node metastasis in papillary thyroid cancer, and the receiver operating characteristic (ROC) curve was employed to assess their diagnostic efficiency. Significant differences were observed in the number of lesions, nodule size, calcification, blood flow RI, and PI values comparison between the two arms (P < 0.05), while no significant differences were found in other ultrasound signs (P > 0.05). Patients with neck lymph node metastasis exhibited significantly higher serum concentrations of thyroid stimulating hormone (TSH) and anti-thyroglobulin antibodies (TG-Ab) versus those without metastasis (P < 0.05). Nodule size, number of lesions, and serum TSH level were independent risk factors for metastasis in neck lymph nodes in patients with papillary thyroid cancer (P <0.05). Conventional ultrasound signs, combined with serologic indices, demonstrated the highest diagnostic efficiency for predicting neck lymph node metastasis in patients with papillary thyroid cancer. These findings showed a sensitivity of 0.868, specificity of 0.894, and an area under the ROC curve (AUC) of 0.918. Additionally, the Jorden index was calculated to be 0.761. Analysis revealed that nodule size, number of lesions, and serum TSH concentration were independent risk factors for neck lymph node metastasis in papillary thyroid cancer patients. The combination of conventional ultrasound signs and serologic indices provided a higher diagnostic value compared to using a single diagnostic modality, thus indicating promising clinical benefits.
{"title":"The Predictive Value of Conventional Ultrasound Signs Plus Serological Indices for Neck Lymph Node Metastasis in Papillary Thyroid Cancer","authors":"Sha Liu, MengMeng Chou","doi":"10.1166/jbt.2024.3354","DOIUrl":"https://doi.org/10.1166/jbt.2024.3354","url":null,"abstract":"The present study aimed to evaluate the predictive value of conventional ultrasound signs and serological indices in the detection of neck lymph node metastasis in papillary thyroid cancer (PTC). A total of 80 patients with PTC scheduled for surgery in our hospital between August 2019\u0000 and December 2022 were recruited. Patients with neck lymph node metastasis were categorized as the experimental group, and patients without neck lymph node metastasis were included in the control group. Patients’ ultrasound signs were analyzed, and serological indices were determined.\u0000 Logistic analysis was performed to determine the risk factors for the development of postoperative neck lymph node metastasis in papillary thyroid cancer, and the receiver operating characteristic (ROC) curve was employed to assess their diagnostic efficiency. Significant differences were\u0000 observed in the number of lesions, nodule size, calcification, blood flow RI, and PI values comparison between the two arms (P < 0.05), while no significant differences were found in other ultrasound signs (P > 0.05). Patients with neck lymph node metastasis exhibited significantly\u0000 higher serum concentrations of thyroid stimulating hormone (TSH) and anti-thyroglobulin antibodies (TG-Ab) versus those without metastasis (P < 0.05). Nodule size, number of lesions, and serum TSH level were independent risk factors for metastasis in neck lymph nodes in patients\u0000 with papillary thyroid cancer (P <0.05). Conventional ultrasound signs, combined with serologic indices, demonstrated the highest diagnostic efficiency for predicting neck lymph node metastasis in patients with papillary thyroid cancer. These findings showed a sensitivity of 0.868,\u0000 specificity of 0.894, and an area under the ROC curve (AUC) of 0.918. Additionally, the Jorden index was calculated to be 0.761. Analysis revealed that nodule size, number of lesions, and serum TSH concentration were independent risk factors for neck lymph node metastasis in papillary thyroid\u0000 cancer patients. The combination of conventional ultrasound signs and serologic indices provided a higher diagnostic value compared to using a single diagnostic modality, thus indicating promising clinical benefits.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"37 16","pages":""},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140517950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review thoroughly investigates the latest developments and challenges of nanobiomaterials in bone regeneration. It begins by elucidating the fundamental properties of nanomaterials and their unique role in promoting bone cell proliferation and differentiation. The review further explores innovative applications of nanobiomaterials in enhancing bone regeneration efficiency, and reducing immune reactions and toxicity, while also discussing the current technological limitations and future possibilities. Conclusively, the article predicts the future applications of nanobiomaterials in bone regeneration treatments, especially highlighting their potential role in personalized medicine and bioprinting technologies.
{"title":"Application and Potential of Nanobiomaterials in Bone Regeneration","authors":"Wenting Zhou, Rui He, Ran Du, Bingyang Chu","doi":"10.1166/jbt.2024.3350","DOIUrl":"https://doi.org/10.1166/jbt.2024.3350","url":null,"abstract":"This review thoroughly investigates the latest developments and challenges of nanobiomaterials in bone regeneration. It begins by elucidating the fundamental properties of nanomaterials and their unique role in promoting bone cell proliferation and differentiation. The review further\u0000 explores innovative applications of nanobiomaterials in enhancing bone regeneration efficiency, and reducing immune reactions and toxicity, while also discussing the current technological limitations and future possibilities. Conclusively, the article predicts the future applications of nanobiomaterials\u0000 in bone regeneration treatments, especially highlighting their potential role in personalized medicine and bioprinting technologies.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"10 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140519283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the effect of magnesium sulfate combined with ritodrine hydrochloride on maternal and infant outcomes in patients with premature rupture of membranes (PROM), a total of 76 PROM patients admitted to our hospital from July 2021 to July 2022 were selected as the research objects, and they were divided into observation group and experimental group according to the treatment methods of the patients. The observation group consisted of 38 patients who received magnesium sulfate monotherapy, whereas the experimental group received ritodrine hydrochloride in addition to the treatment received by the patients in the observation group. The treatment effects, levels of inflammatory factors, negative emotions, as well as maternal and child outcomes, along with any adverse reactions during the medication, were compared between the two groups. The effective rate of treatment in the observation group was 78.95%, and that in the experimental group was 97.37%. The effective rate in the experimental group was significantly higher than that in the observation group (P < 0.05). The levels of α and IFN-y were significantly lower than those of the observation group (all, P < 0.05); the SAS scores and SDS scores of the experimental group after treatment were significantly lower than those of the observation group (all, P < 0.05). The observation group showed significantly lower uterine contraction inhibition time and postpartum hemorrhage compared to the observation group, along with significantly higher gestational age extension time (all, P <0.05). In terms of neonatal outcomes, the birth weight, Apgar. The scores were significantly higher than those of the observation group, and the incidence of complications was significantly lower than that of the observation group (all, P < 0.05). The incidence of adverse reactions in the observation group was 21.05%, compared to 23.68% in the experimental group. There was no significant difference in the incidence of adverse reactions between the two groups of patients (P > 0.05). Magnesium sulfate combined with ritodrine hydrochloride has a significant effect in the treatment of patients with PROM. The application of the combined program can effectively reduce the inflammatory response of patients, regulate the negative emotions of patients, and improve the maternal and infant outcomes of patients. Moreover, the combined program does not increase the risk of adverse reactions in patients, demonstrating its ideal safety in clinical medication.
为探究硫酸镁联合盐酸利托君对胎膜早破（PROM）患者母婴结局的影响，选取我院2021年7月-2022年7月收治的76例胎膜早破（PROM）患者作为研究对象，根据患者的治疗方法分为观察组和实验组。观察组 38 例患者接受硫酸镁单药治疗，实验组在观察组患者治疗的基础上加用盐酸利托君。对两组患者的治疗效果、炎症因子水平、负面情绪、母婴结局以及用药期间的不良反应进行了比较。观察组的治疗有效率为 78.95%，实验组为 97.37%。实验组的有效率明显高于观察组（P < 0.05）。实验组的α和IFN-y水平明显低于观察组（均P＜0.05）；实验组治疗后的SAS评分和SDS评分明显低于观察组（均P＜0.05）。观察组的子宫收缩抑制时间和产后出血量明显低于观察组，胎龄延长时间明显高于观察组（均为 P 0.05）。硫酸镁联合盐酸利托君治疗PROM患者效果显著。联合方案的应用能有效减轻患者的炎症反应，调节患者的不良情绪，改善患者的母婴预后。此外，联合方案不会增加患者出现不良反应的风险，体现了其在临床用药中的理想安全性。
{"title":"Significant Effect of Ritodrine Hydrochloride Combined with Magnesium Sulfate for Treatment of Patients with Premature Rupture of Membranes","authors":"Fulin Tian, Jun Zhang, Jun Liu","doi":"10.1166/jbt.2024.3355","DOIUrl":"https://doi.org/10.1166/jbt.2024.3355","url":null,"abstract":"To investigate the effect of magnesium sulfate combined with ritodrine hydrochloride on maternal and infant outcomes in patients with premature rupture of membranes (PROM), a total of 76 PROM patients admitted to our hospital from July 2021 to July 2022 were selected as the research\u0000 objects, and they were divided into observation group and experimental group according to the treatment methods of the patients. The observation group consisted of 38 patients who received magnesium sulfate monotherapy, whereas the experimental group received ritodrine hydrochloride in addition\u0000 to the treatment received by the patients in the observation group. The treatment effects, levels of inflammatory factors, negative emotions, as well as maternal and child outcomes, along with any adverse reactions during the medication, were compared between the two groups. The effective\u0000 rate of treatment in the observation group was 78.95%, and that in the experimental group was 97.37%. The effective rate in the experimental group was significantly higher than that in the observation group (P < 0.05). The levels of α and IFN-y were significantly lower\u0000 than those of the observation group (all, P < 0.05); the SAS scores and SDS scores of the experimental group after treatment were significantly lower than those of the observation group (all, P < 0.05). The observation group showed significantly lower uterine contraction\u0000 inhibition time and postpartum hemorrhage compared to the observation group, along with significantly higher gestational age extension time (all, P <0.05). In terms of neonatal outcomes, the birth weight, Apgar. The scores were significantly higher than those of the observation group,\u0000 and the incidence of complications was significantly lower than that of the observation group (all, P < 0.05). The incidence of adverse reactions in the observation group was 21.05%, compared to 23.68% in the experimental group. There was no significant difference in the incidence\u0000 of adverse reactions between the two groups of patients (P > 0.05). Magnesium sulfate combined with ritodrine hydrochloride has a significant effect in the treatment of patients with PROM. The application of the combined program can effectively reduce the inflammatory response of\u0000 patients, regulate the negative emotions of patients, and improve the maternal and infant outcomes of patients. Moreover, the combined program does not increase the risk of adverse reactions in patients, demonstrating its ideal safety in clinical medication.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"20 4","pages":""},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140518973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ying Zhang, Kai Li, Changfeng Li, Meng Ding, Ruisi Xu
{"title":"The Real-Time Detection of Mouse Double Minute-2 mRNA Expression in Living Cells with the Gold Nanoparticle (Journal of Biomaterials and Tissue Engineering, Vol. 8(1), pp. 27–34 (2018))","authors":"Ying Zhang, Kai Li, Changfeng Li, Meng Ding, Ruisi Xu","doi":"10.1166/jbt.2024.3360","DOIUrl":"https://doi.org/10.1166/jbt.2024.3360","url":null,"abstract":"","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"35 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to assess enamel demineralization depth following the use of different bracket materials, etchants, and adhesive systems. Ninety-nine extracted human premolars were assigned to nine groups (eight experimental and one control), each including 11 specimens. The experimental groups were bonded to either metal or ceramic brackets and prepared using a total-or self-etchant with a pre-coated or flash-free adhesive system. All specimens were immersed in an artificial demineralization solution for 7 days at pH 4.5 and 37 °C. The brackets were debonded, and the specimens were sectioned buccolingually at the right and left sides of the bracket base margins. Scanning electron microscopy was used to assess the demineralization depth using ImageJ software. Significantly deeper enamel demineralization was observed in all bonded teeth compared to non-bonded teeth (p < 0.001). The adhesive system had no significant effect on the demineralization depth. Metal brackets caused significantly deeper enamel demineralization than ceramic brackets (p <0.005). The use of the total-etch surface treatment caused deeper demineralization compared to that of the self-etch treatment. In conclusion, bonded teeth exhibit deeper enamel demineralization than non-bonded teeth. Metal brackets contribute to deeper demineralization than ceramic brackets. The total-etch surface treatment caused deeper demineralization than self-etch when combined with metal brackets and a pre-coated adhesive system.
{"title":"Assessment of Enamel Demineralization Following the Use of Different Orthodontic Bracket Materials, Etchants, and Adhesive Systems: An In Vitro Study","authors":"Rahaf Zawawi, Naif A. Almosa","doi":"10.1166/jbt.2023.3322","DOIUrl":"https://doi.org/10.1166/jbt.2023.3322","url":null,"abstract":"The aim of this study was to assess enamel demineralization depth following the use of different bracket materials, etchants, and adhesive systems. Ninety-nine extracted human premolars were assigned to nine groups (eight experimental and one control), each including 11 specimens. The experimental groups were bonded to either metal or ceramic brackets and prepared using a total-or self-etchant with a pre-coated or flash-free adhesive system. All specimens were immersed in an artificial demineralization solution for 7 days at pH 4.5 and 37 °C. The brackets were debonded, and the specimens were sectioned buccolingually at the right and left sides of the bracket base margins. Scanning electron microscopy was used to assess the demineralization depth using ImageJ software. Significantly deeper enamel demineralization was observed in all bonded teeth compared to non-bonded teeth (p < 0.001). The adhesive system had no significant effect on the demineralization depth. Metal brackets caused significantly deeper enamel demineralization than ceramic brackets (p <0.005). The use of the total-etch surface treatment caused deeper demineralization compared to that of the self-etch treatment. In conclusion, bonded teeth exhibit deeper enamel demineralization than non-bonded teeth. Metal brackets contribute to deeper demineralization than ceramic brackets. The total-etch surface treatment caused deeper demineralization than self-etch when combined with metal brackets and a pre-coated adhesive system.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"93 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Al-Aali, Abeer R. Alshehri, Hiba R. Talic, Ayaan A. Magan, Felwa K. Alhomody
Aim: This study aimed to compare the conventional, digital, and three-dimensional (3D)-printed casts in terms of their accuracy in quantifying arch and teeth measurements. Materials and Methods: The conventional casts were prepared using polyether dental impressions. Digital impressions of the typodont reference casts were accomplished using an intra-oral scanner. The digital casts were first converted to stereolithography (STL) files which were then edited, and printed using an SLA printer and photo-polymer resin material. The measurements of the first two groups were completed using a digital caliper, while an imaging software was used to measure digital casts. The occlusocervial (OC) height and mesiodistal (MD) width of canines, second premolars (PMs), and molars of each jaw were measured. Additionally, intercanine width (ICW) and intermolar width (IMW) were also measured. Results: Overall, the lowest OC measurement errors were observed for 3D-printed casts for the upper canine, lower canine, and lower molar (0.003±0.01 mm). Similarly, the lowest MD measurement errors were observed for 3D-printed casts for upper canine, upper PM, and lower PM (0.002±0.01 mm). The ICW and IMW measurement errors for the 3D-printed casts were significantly lower (p < 0.01) for the upper ICW (0.011±0.01 mm) and lower IMW (0.017±0.01 mm) than the other two groups. Compared to the conventional and digital casts, the lower ICW (0.013±0.01 mm) and upper IMW (0.017±0.01 mm) measurement errors observed for the 3D-printed casts were also lower, but non-significantly (p > 0.01). Conclusions: 3D-printed casts presented the lowest OC, MD, ICW, and IMW measurement errors, than the conventional and digital casts. The highest measurement errors were associated with the digital casts.
{"title":"Dimensional Accuracy of 3D-Printed, Digital and Conventional Stone Dental Cast of Dentate Patients Using Arch and Teeth Measurements","authors":"K. Al-Aali, Abeer R. Alshehri, Hiba R. Talic, Ayaan A. Magan, Felwa K. Alhomody","doi":"10.1166/jbt.2023.3316","DOIUrl":"https://doi.org/10.1166/jbt.2023.3316","url":null,"abstract":"Aim: This study aimed to compare the conventional, digital, and three-dimensional (3D)-printed casts in terms of their accuracy in quantifying arch and teeth measurements. Materials and Methods: The conventional casts were prepared using polyether dental impressions. Digital impressions of the typodont reference casts were accomplished using an intra-oral scanner. The digital casts were first converted to stereolithography (STL) files which were then edited, and printed using an SLA printer and photo-polymer resin material. The measurements of the first two groups were completed using a digital caliper, while an imaging software was used to measure digital casts. The occlusocervial (OC) height and mesiodistal (MD) width of canines, second premolars (PMs), and molars of each jaw were measured. Additionally, intercanine width (ICW) and intermolar width (IMW) were also measured. Results: Overall, the lowest OC measurement errors were observed for 3D-printed casts for the upper canine, lower canine, and lower molar (0.003±0.01 mm). Similarly, the lowest MD measurement errors were observed for 3D-printed casts for upper canine, upper PM, and lower PM (0.002±0.01 mm). The ICW and IMW measurement errors for the 3D-printed casts were significantly lower (p < 0.01) for the upper ICW (0.011±0.01 mm) and lower IMW (0.017±0.01 mm) than the other two groups. Compared to the conventional and digital casts, the lower ICW (0.013±0.01 mm) and upper IMW (0.017±0.01 mm) measurement errors observed for the 3D-printed casts were also lower, but non-significantly (p > 0.01). Conclusions: 3D-printed casts presented the lowest OC, MD, ICW, and IMW measurement errors, than the conventional and digital casts. The highest measurement errors were associated with the digital casts.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"2 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139365912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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