Vaccination and modern management of chronic obstructive pulmonary disease – a narrative review

IF 2.9 3区医学 Q2 RESPIRATORY SYSTEM Expert Review of Respiratory Medicine Pub Date : 2022-06-03 DOI:10.1080/17476348.2022.2092099

Oana Joean, T. Welte

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引用次数: 2

Abstract

ABSTRACT Introduction Chronic obstructive pulmonary disease (COPD) carries a tremendous societal and individual burden, posing significant challenges for public health systems worldwide due to its high morbidity and mortality. Due to aging and multimorbidity but also in the wake of important progress in deciphering the heterogeneous disease endotypes, an individualized approach to the prevention and management of COPD is necessary. Areas covered This article tackles relevant immunization strategies that are available or still under development with a focus on the latest evidence but also controversies around different regional immunization approaches. Further, we present the crossover between chronic lung inflammation and lung microbiome disturbance as well as its role in delineating COPD endotypes. Moreover, the article attempts to underline endotype-specific treatment approaches. Lastly, we highlight non-pharmacologic prevention and management programs in view of the challenges and opportunities of the COVID-19 era. Expert opinion Despite the remaining challenges, personalized medicine has the potential to offer tailored approaches to prevention and therapy and promises to improve the care of patients living with COPD.

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慢性阻塞性肺病的疫苗接种和现代管理——叙述性综述

慢性阻塞性肺疾病(COPD)具有巨大的社会和个人负担，由于其高发病率和死亡率，对全球公共卫生系统构成了重大挑战。由于老龄化和多发病，以及在破译异质性疾病内型方面取得的重要进展，有必要采取个体化的方法来预防和管理COPD。本文讨论了现有的或正在制定的相关免疫战略，重点关注最新证据，但也讨论了围绕不同区域免疫方法的争议。此外，我们提出了慢性肺部炎症和肺微生物群紊乱之间的交叉，以及它在描述COPD内型中的作用。此外，文章试图强调内源性特异性治疗方法。最后，针对新冠肺炎时代的挑战和机遇，重点介绍非药物预防和管理方案。专家意见尽管仍然存在挑战，个性化医疗有可能提供量身定制的预防和治疗方法，并有望改善COPD患者的护理。

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来源期刊

Expert Review of Respiratory Medicine RESPIRATORY SYSTEM-

CiteScore

6.80

自引率

2.60%

发文量

期刊介绍： Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity