Clinical, endoscopic and pathological features of early Barrett esophageal adenocarcinoma and its treatment efficacy by endoscopic submucosal dissection

Rong-Xi Li, Huihong Zhai, J. Xing, Peng Li
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Abstract

Objective To investigate the clinical, endoscopic and pathological characteristics of early Barrett esophageal adenocarcinoma (BEA) and to evaluate the treatment efficacy of endoscopic submucosal dissection (ESD). Methods Data of 13 patients who were diagnosed as early BEA and treated by ESD in Beijing Friendship Hospital from November 2015 to June 2018 were retrospectively analyzed, including clinical data, endoscopic manifestations and pathological information. Results Out of 13 patients, 10 were male. One had underlying long-segment Barrett esophagus (LSBE), 6 had short-segment Barrett esophagus (SSBE), and 6 had super short-segment Barrett esophagus (less than 1 cm). Two arose from circumferential Barrett esophageal (BE) and 11 from tongue-like BE. Ten lesions were located on the right anterior side wall (12-2 o′clock) of the esophagogastric junction (EGJ), and 12 lesions were superficial type (0-Ⅱ). ESD was successfully conducted in all the patients without any complication. The en bloc and curative resection rate was 100% (13/13) and 92% (12/13), respectively. Pathology examination found 9 well-differentiated adenocarcinoma and 10 intramucosal cancer. No recurrence was detected in 11 patients during follow-up of 3.3-29.3 months. Conclusion Early BEA tends to occur in elderly male, and mostly originated from non-LSBE and tongue-like BE. Most lesions are superficial type and located on the right anterior side wall of EGJ. In pathology, most lesions are well-differentiated adenocarcinoma and limited to the mucosa. ESD is a safe and efficient treatment for BEA. Key words: Barrett esophagus; Adenocarcinoma; Clinical feature; Endoscopic feature; Pathologic feature; Endoscopic submucosal dissection
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早期Barrett食管腺癌的临床、内镜、病理特点及内镜黏膜下剥离术的疗效
目的探讨早期Barrett食管腺癌(BEA)的临床、内镜及病理特点,评价内镜下粘膜剥离术(ESD)的治疗效果。方法回顾性分析2015年11月至2018年6月在北京友谊医院接受ESD治疗的13例早期BEA患者的临床资料、内镜表现及病理资料。结果13例患者中,男性10例。1例为基础长段Barrett食管(LSBE), 6例为短段Barrett食管(SSBE), 6例为超短段Barrett食管(小于1 cm)。2例来自环形Barrett食管(BE), 11例来自舌状BE。10个病变位于食管胃交界(EGJ)右侧前侧壁(12-2点钟方向),12个病变为浅表型(0-Ⅱ)。所有患者均成功行ESD,无并发症。整体和治愈率分别为100%(13/13)和92%(12/13)。病理检查发现高分化腺癌9例,粘膜内癌10例。11例患者随访3.3 ~ 29.3个月,无复发。结论早期BEA多见于老年男性,多以非lsbe和舌状BEA为主。大多数病变为浅表性,位于EGJ右侧前侧壁。病理上,大多数病变为分化良好的腺癌,局限于粘膜。ESD是一种安全有效的BEA治疗方法。关键词:Barrett食管;腺癌;临床特征;内镜特征;病理特征;内镜下粘膜夹层
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来源期刊
CiteScore
0.10
自引率
0.00%
发文量
7555
期刊介绍: Chinese Journal of Digestive Endoscopy is a high-level medical academic journal specializing in digestive endoscopy, which was renamed Chinese Journal of Digestive Endoscopy in August 1996 from Endoscopy. Chinese Journal of Digestive Endoscopy mainly reports the leading scientific research results of esophagoscopy, gastroscopy, duodenoscopy, choledochoscopy, laparoscopy, colorectoscopy, small enteroscopy, sigmoidoscopy, etc. and the progress of their equipments and technologies at home and abroad, as well as the clinical diagnosis and treatment experience. The main columns are: treatises, abstracts of treatises, clinical reports, technical exchanges, special case reports and endoscopic complications. The target readers are digestive system diseases and digestive endoscopy workers who are engaged in medical treatment, teaching and scientific research. Chinese Journal of Digestive Endoscopy has been indexed by ISTIC, PKU, CSAD, WPRIM.
期刊最新文献
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