Assessment of the serum level of IL-1B, IL-2, and IL-10 in children infected with Enterobius vermicularis in Babylon province

Abstract

Background: Children are most frequently infected with Enterobius vermicularis, a human-pathogenic intestinal parasite that belongs to the nematodes and causes enterobiasis. Objectives: Evaluation of interleukin (IL)-1B and IL-2 levels in pinworm-infected youngsters is the goal. Materials and Methods: A total of 87 children—including 30 control subjects—participated in this study. Their ages ranged from 2 to 13 years old, and both sexes (50 females and 37 males) were represented. IL-1B, IL-2, and IL-10 levels were measured using an enzyme-linked immunosorbent assay test. Results: When using the cellophane tape method, the results showed that 53 (60.92%) clinically infected patients had laboratory examinations, whereas all 87 (100.0%) clinically infected patients had positive diagnostic results. Additionally, the level of proinflammatory cytokines (IL-1B and IL-2) was slightly higher in the intestinal E. vermicularis, a human-pathogenic organism shown to be somewhat more prevalent in patients than in the control group in this investigation. Thirty children participated in the study. Additionally, the level of IL-10 did not increase much (P = 0.005). Conclusion: There was increasing serum of IL-1B, IL-2, and IL-10 in patients with enterobiasis.