Study of Urinary Uric Acid and Creatinine Ratio as a Marker of PerinatalAsphyxia and Its Correlation with Different Stages of Hypoxic IschemicEncephalopathy
{"title":"Study of Urinary Uric Acid and Creatinine Ratio as a Marker of PerinatalAsphyxia and Its Correlation with Different Stages of Hypoxic IschemicEncephalopathy","authors":"Lokesh Choudhary, Subhash Palsania, Pk Berwal, Chhavi Sauparna, Ankita Maheshwari","doi":"10.4172/2376-127X.1000336","DOIUrl":null,"url":null,"abstract":"Background: Birth asphyxia is one of the leading causes of neonatal mortality in India. Hypoxic-ischemic encephalopathy (HIE) is the neurological manifestation of systemic hypoxia in new-born. 20-25% of asphyxiated babies who exhibit severe HIE, die during the new-born period. The most commonly used diagnostic and prognostic index to evaluate asphyxia in neonates is APGAR score but alone it is not useful to ferret out neurological outcome. Now-a-days uses of biomarkers enable the clinicians to screen infants for brain injury. We conducted this study to evaluate the role of UUA (urinary uric acid)/Cr (creatinine), which is an early biomarker, in diagnosing and predicting the outcome in perinatal asphyxia. Aim: To determine the values of UUA/Cr in new-borns with perinatal asphyxia and its relation with different stages of HIE. Methods: Spot urine samples were collected from the 100 asphyxiated and 100 healthy neonates within 6-24 h of life for determining uric acid and creatinine by auto analyses. Results: The value of UUA/Cr were statistically significantly higher in the asphyxiated (case) compared with the control group. UUA/Cr ratios were significantly higher in infants with severe HIE (3.61 ± 0.61) when compared with infants with Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation moderate HIE (2.95 ± 0.98: P<0.01) and those with mild HIE (2.64 ± 0.25: P<0.001). Conclusion: UUA/Cr concentration increase considerably after birth asphyxia and is non-invasive, sensitive, early and cost effective method for assessment of asphyxia and its outcome.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-127X.1000336","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pregnancy and child health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2376-127X.1000336","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Background: Birth asphyxia is one of the leading causes of neonatal mortality in India. Hypoxic-ischemic encephalopathy (HIE) is the neurological manifestation of systemic hypoxia in new-born. 20-25% of asphyxiated babies who exhibit severe HIE, die during the new-born period. The most commonly used diagnostic and prognostic index to evaluate asphyxia in neonates is APGAR score but alone it is not useful to ferret out neurological outcome. Now-a-days uses of biomarkers enable the clinicians to screen infants for brain injury. We conducted this study to evaluate the role of UUA (urinary uric acid)/Cr (creatinine), which is an early biomarker, in diagnosing and predicting the outcome in perinatal asphyxia. Aim: To determine the values of UUA/Cr in new-borns with perinatal asphyxia and its relation with different stages of HIE. Methods: Spot urine samples were collected from the 100 asphyxiated and 100 healthy neonates within 6-24 h of life for determining uric acid and creatinine by auto analyses. Results: The value of UUA/Cr were statistically significantly higher in the asphyxiated (case) compared with the control group. UUA/Cr ratios were significantly higher in infants with severe HIE (3.61 ± 0.61) when compared with infants with Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation moderate HIE (2.95 ± 0.98: P<0.01) and those with mild HIE (2.64 ± 0.25: P<0.001). Conclusion: UUA/Cr concentration increase considerably after birth asphyxia and is non-invasive, sensitive, early and cost effective method for assessment of asphyxia and its outcome.
背景:出生窒息是印度新生儿死亡的主要原因之一。缺氧缺血性脑病(HIE)是新生儿全身缺氧的神经系统表现。20-25%表现出严重HIE的窒息婴儿在新生儿时期死亡。评估新生儿窒息最常用的诊断和预后指标是APGAR评分,但单独使用它对找出神经系统结果没有帮助。生物标志物的日常使用使临床医生能够筛查婴儿的脑损伤。我们进行这项研究是为了评估UUA(尿尿酸)/Cr(肌酸酐)作为一种早期生物标志物在诊断和预测围产期窒息结局中的作用。目的:探讨新生儿围产期窒息UUA/Cr的变化及其与HIE不同阶段的关系。方法:采集100例窒息新生儿和100例健康新生儿在6~24小时内的现场尿液样本,用自动分析法测定尿酸和肌酐。结果:与对照组相比,窒息组(例)的UUA/Cr值有统计学意义。与Aries Systems Corporation的Powered by Editorial Manager®和ProduXion Manager®中度HIE(2.95±0.98:P<0.01)和轻度HIE(2.64±0.25:P<0.001)相比,重度HIE婴儿的UUA/Cr比率显著更高(3.61±0.61),用于评估窒息及其结果的早期且成本有效的方法。